Results 31 to 40 of about 67,253 (293)
Journal of Functional Biomaterials, 2012 Biopolymers are easily denatured by heating, a change in pH or chemical substances when they are immobilized on a substrate. To prevent denaturation of biopolymers, we developed a method to trap a polynucleotide on a substrate by hydrogen bonding using ...
R. Maeda, T. Isoda
doaj +1 more source
, 2011 Electron Paramagnetic Resonance (EPR) spectroscopy and fluorescence spectroscopy are complementary biophysical techniques used to examine the structure and dynamics of macromolecules.
Reginsson, Gunnar Widtfeldt +13 more
core +1 more source
A Rapid and Low-Cost PCR Thermal Cycler for Low Resource Settings. [PDF]
PLoS ONE, 2015 Many modern molecular diagnostic assays targeting nucleic acids are typically confined to developed countries or to the national reference laboratories of developing-world countries.
Grace Wong +4 more
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Simplified Paper Format for Detecting HIV Drug Resistance in Clinical Specimens by Oligonucleotide Ligation. [PDF]
PLoS ONE, 2016 Human immunodeficiency virus (HIV) is a chronic infection that can be managed by antiretroviral treatment (ART). However, periods of suboptimal viral suppression during lifelong ART can select for HIV drug resistant (DR) variants.
Nuttada Panpradist +5 more
doaj +1 more source
Emergent Properties and Functions of Nanoconfined Nucleic Acid Architectures
, 2015 The facile ability of DNA to self-assemble has enabled the creation of complex architectures with diverse functions on surfaces or in solution. This approach provides a powerful design tool for the development of nanoscale devices with transformative ...
Lucia Coral +11 more
core +1 more source
Cold Denaturation of the Hammerhead Ribozyme
, 2016 Cold denaturation is a thermodynamic phenomenon resulting from a difference in the heat capacities, ΔCp, of the folded and unfolded states of a macromolecule.
Peter J. Mikulecky (2716048) +1 more
core +2 more sources
Effects of osmolytes and macromolecular crowders on stable GAAA tetraloops and their preference for a CG closing base pair [PDF]
PeerJ, 2018 Osmolytes and macromolecular crowders have the potential to influence the stability of secondary structure motifs and alter preferences for conserved nucleic acid sequences in vivo.
Kaethe N. Leonard, Joshua M. Blose
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Accurate quantification of nucleic acids using hypochromicity measurements in conjunction with UV spectrophotometry [PDF]
, 2017 UV absorbance spectrophotometry is widely used for the quantification of nucleic acids. For accurate quantification it is important to determine the hypochromocity of the oligonucleotide or complex nucleic acid structure.
David E. Portwood +7 more
core +1 more source
FEBS Open Bio, EarlyView.TisIBP8, a fungal‐derived hyperactive ice‐binding protein, helps Caenorhabditis elegans survive dehydration. It localizes near cell membranes, reduces cell damage, and helps maintain membrane structure during drying. These results suggest that ice‐binding proteins can protect cells from dehydration stress as well as freezing stress.
Daiki Shimose +9 more
wiley +1 more source
Virology JournalBackground Almost all cases of cervical cancer are associated with persistent high-risk HPV infection. WHO prioritizes primary HPV testing for cervical cancer screening.
Fatih Çubuk +6 more
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