Results 181 to 190 of about 27,476 (204)

Nucleocytoplasmic mRNA Transport

2001
How do messenger RNA molecules (mRNAs) migrate from the nucleus to the cytoplasm? Messenger RNA precursors (pre-mRNAs) are synthesized in the nucleus by RNA polymerase II and are then subjected to a series of processing reactions which include the addition of a 7-methylguanosine cap at the 5’ end, the removal of introns by splicing, and the generation ...
Y, Huang, G G, Carmichael
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Nucleocytoplasmic transport of macromolecules.

Microbiology and molecular biology reviews : MMBR, 1997
Nucleocytoplasmic transport is a complex process that consists of the movement of numerous macromolecules back and forth across the nuclear envelope. All macromolecules that move in and out of the nucleus do so via nuclear pore complexes that form large proteinaceous channels in the nuclear envelope.
A H, Corbett, P A, Silver
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Nucleocytoplasmic transport of proteins

Biochemistry (Moscow), 2007
In eukaryotic cells, the movement of macromolecules between the nucleus and cytoplasm occurs through the nuclear pore complex (NPC)--a large protein complex spanning the nuclear envelope. The nuclear transport of proteins is usually mediated by a family of transport receptors known as karyopherins.
A V, Sorokin, E R, Kim, L P, Ovchinnikov
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RNA nucleocytoplasmic transport

Seminars in Cell Biology, 1992
The transport of RNAs from the nucleus to the cytoplasm is an obligatory step in gene expression and may also be a target for regulation. The cellular machinery has the capacity to export a myriad of RNA transcripts, which differ significantly in sequence and structure. Recent work is providing the first glimpses into how RNA export occurs.
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Structural Biology of Nucleocytoplasmic Transport

Annual Review of Biochemistry, 2007
In eukaryotic cells, segregation of DNA replication and RNA biogenesis in the nucleus and protein synthesis in the cytoplasm poses the requirement of transporting thousands of macromolecules between the two cellular compartments. Transport between nucleus and cytoplasm is mediated by soluble receptors that recognize specific cargoes and carry them ...
Cook, A., Bono, F., Jinek, M., Conti, E.
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SUMO and Nucleocytoplasmic Transport

2009
The transport of proteins between the nucleus and cytoplasm occurs through nuclear pore complexes and is facilitated by numerous transport factors. These transport processes are often regulated by post-translational modification or, reciprocally, transport can function to control post-translational modifications through regulated transport of key ...
Christopher, Ptak, Richard W, Wozniak
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Karyopherin flexibility in nucleocytoplasmic transport

Current Opinion in Structural Biology, 2006
Recent structural work on nuclear transport factors of the importin-beta superfamily of karyopherins has shown that these proteins are superhelices of HEAT repeats that are able to assume different conformations in different functional states. The inherent flexibility of these helicoids facilitates the accommodation of different binding partners by an ...
Elena, Conti, Christoph W, Müller, Murray, Stewart   +2 more
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Control of nucleocytoplasmic transport

Current Opinion in Cell Biology, 1992
The movement of macromolecules between the nucleus and cytoplasm is tightly controlled. In the past few years it has become increasingly apparent that nuclear traffic is regulated not only by recognition of specific signals on proteins and RNAs, but also by cellular factors that modulate the efficacy with which these signals are recognized.
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Nucleocytoplasmic RNA Transport

1984
During the past decade, it has become evident that, in eukaryotes, RNA molecules undergo a complex series of chemical modifications after transcription and before translation and that some of these modifications coincide with alterations in subcellular distribution.
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Regulated nucleocytoplasmic transport during gametogenesis

Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms, 2012
Gametogenesis is the process by which sperm or ova are produced in the gonads. It is governed by a tightly controlled series of gene expression events, with some common and others distinct for males and females. Nucleocytoplasmic transport is of central importance to the fidelity of gene regulation that is required to achieve the precisely regulated ...
Yoichi, Miyamoto, Peter R, Boag, Gary R, Hime, Kate L, Loveland   +3 more
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