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Nucleocytoplasmic mRNA Transport
2001How do messenger RNA molecules (mRNAs) migrate from the nucleus to the cytoplasm? Messenger RNA precursors (pre-mRNAs) are synthesized in the nucleus by RNA polymerase II and are then subjected to a series of processing reactions which include the addition of a 7-methylguanosine cap at the 5’ end, the removal of introns by splicing, and the generation ...
Y, Huang, G G, Carmichael
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Control of nucleocytoplasmic transport
Current Opinion in Cell Biology, 1992The movement of macromolecules between the nucleus and cytoplasm is tightly controlled. In the past few years it has become increasingly apparent that nuclear traffic is regulated not only by recognition of specific signals on proteins and RNAs, but also by cellular factors that modulate the efficacy with which these signals are recognized.
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RNA nucleocytoplasmic transport
Seminars in Cell Biology, 1992The transport of RNAs from the nucleus to the cytoplasm is an obligatory step in gene expression and may also be a target for regulation. The cellular machinery has the capacity to export a myriad of RNA transcripts, which differ significantly in sequence and structure. Recent work is providing the first glimpses into how RNA export occurs.
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Nucleocytoplasmic RNA Transport
1984During the past decade, it has become evident that, in eukaryotes, RNA molecules undergo a complex series of chemical modifications after transcription and before translation and that some of these modifications coincide with alterations in subcellular distribution.
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Karyopherin flexibility in nucleocytoplasmic transport
Current Opinion in Structural Biology, 2006Recent structural work on nuclear transport factors of the importin-beta superfamily of karyopherins has shown that these proteins are superhelices of HEAT repeats that are able to assume different conformations in different functional states. The inherent flexibility of these helicoids facilitates the accommodation of different binding partners by an ...
Conti, E., Müller, C., Stewart, M.
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The role of nucleocytoplasmic transport in mechanotransduction
Experimental Cell Research, 2019Cells integrate mechanical and biochemical signals via a process called mechanotransduction to generate essential gene expression patterns in space and time. This is vital for cell migration and proliferation as well as tissue morphogenesis and remodeling.
Elena Kassianidou +2 more
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Neurology, 2019
There is a bidirectional communication between the nucleus and the cytoplasm through highly regulated nucleocytoplasmic transport. This process allows the transport of proteins, RNAs, and ribonucleoproteins across the nuclear envelope via the nuclear pore complexes.
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There is a bidirectional communication between the nucleus and the cytoplasm through highly regulated nucleocytoplasmic transport. This process allows the transport of proteins, RNAs, and ribonucleoproteins across the nuclear envelope via the nuclear pore complexes.
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Intracellular Structure and Nucleocytoplasmic Transport
1996Intracellular movement of any solute or particle accords with one of two general schemes: either it takes place predominantly in the solution phase or it occurs by dynamic interactions with solid-state structures. If nucleocytoplasmic exchanges of macromolecules and complexes are predominantly solution-phase processes, i.e., if the former ...
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Ran in Nucleocytoplasmic Transport
2014The Ran GTPase is a crucial component of all nucleocytoplasmic transport pathways except those that mediate the nuclear export of mRNAs and ribosome subunits. The nucleotide state of Ran provides a means by which the cytoplasmic and nucleoplasmic compartments are recognized as a consequence of RCC1, the Ran guanine nucleotide exchange factor (RanGEF ...
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Introduction to Nucleocytoplasmic Transport
2006Nucleocytoplasmic transport, the exchange of matter between nucleus and cytoplasm, plays a fundamental role in human and other eukaryotic cells, affecting almost every aspect of health and disease. The only gate for the transport of small and large molecules as well as supramolecular complexes between nucleus and cytoplasm is the nuclear pore complex ...
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