Results 141 to 150 of about 23,876 (290)
Comparative interactomics provides evidence for functional specialization of the nuclear pore complex [PDF]
, 2017 The core architecture of the eukaryotic cell was established well over one billion years ago, and is largely retained in all extant lineages. However, eukaryotic cells also possess lineage-specific features, frequently keyed to specific functional ...
Field, Mark C. +2 more
core +2 more sources
Advances and Applications of Spatial Proteomics: From Organellar Maps to Clinical Translation
ChemBioChem, Volume 27, Issue 1, January 2026.Spatial proteomics provides high‐resolution maps of protein localization and trafficking by combining advanced mass spectrometry with complementary imaging and computational tools. Emerging low‐input and automated workflows are expanding its applicability to challenging clinical samples, supporting mechanistic disease research and biomarker discovery ...
Chiara Bernardini +2 more
wiley +1 more source
Dynamic Rearrangement of Nucleoporins during Fungal “Open” Mitosis [PDF]
Molecular Biology of the Cell, 2008 Mitosis in animals starts with the disassembly of the nuclear pore complexes and the breakdown of the nuclear envelope. In contrast to many fungi, the corn smut fungus Ustilago maydis also removes the nuclear envelope. Here, we report on the dynamic behavior of the nucleoporins Nup214, Pom152, Nup133, and Nup107 in this “open” fungal mitosis.
Theisen, Ulrike +2 more
openaire +2 more sources
Nature Communications, 2016 As signalling molecules, bile acids (BAs) can affect metabolism, but due to detergent-like properties, BA levels must be tightly regulated. Here, Kim et al.show that RanBP2, a nucleoporin, maintains BA homoeostasis through SUMOylation of Small ...
Dong-Hyun Kim +8 more
doaj +1 more source
Architecture of the nuclear pore complex coat [PDF]
, 2015 The nuclear pore complex (NPC) constitutes the sole gateway for bidirectional nucleocytoplasmic transport. Despite half a century of structural characterization, the architecture of the NPC remains unknown.
Correia, Ana R. +6 more
core +2 more sources
Human Mutation, 2018 Atrial fibrillation (AF) is the most common cardiac arrhythmia. Here, we show the identification and functional characterization of one AF‐associated mutation p.Arg399Cys in lamin A/C.
Meng Han +13 more
semanticscholar +1 more source
ChemBioChem, Volume 27, Issue 1, January 2026.Quantitative proteomics reveal distinct activities of speckle‐type POZ protein (SPOP) cancer mutants. SPOP‐F133L, unlike F102C, retains degradation of NUP153 and TPR, and partially down‐regulates p53 through a Cullin‐RING ligase‐dependent mechanism. Both mutants support targeted protein degradation in engineered cells, highlighting opportunities to ...
Alana G. Caldwell +4 more
wiley +1 more source
Modeling HIV-1 nuclear entry with nucleoporin-gated DNA-origami channels
Nature Structural & Molecular Biology, 2023 Qi Shen +13 more
semanticscholar +1 more source
Genetic Analyses of Elys Mutations in Drosophila Show Maternal-Effect Lethality and Interactions with Nucleoporin Genes [PDF]
, 2018 ELYS determines the subcellular localizations of Nucleoporins (Nups) during interphase and mitosis. We made loss-of-function mutations of Elys in Drosophila melanogaster and found that ELYS is dispensable for zygotic viability and male fertility but the ...
Awasaki Takeshi +9 more
core +2 more sources
Nature Communications, 2018 Genomic imprinting is a phenomenon that restricts transcription to predominantly one parental allele. How this transcriptional duality is regulated is poorly understood.
Saqib S. Sachani +6 more
semanticscholar +1 more source