Results 121 to 130 of about 101,993 (329)

The diagnostic performance of the basic versus the detailed telomere Flow FISH test in young patients with aplastic anaemia

British Journal of Haematology, EarlyView.
Summary Identifying telomere biology disorders (TBDs) in patients with aplastic anaemia (AA) is essential for guiding appropriate care. Telomere length (TL) measurement by flow cytometry with fluorescence in situ hybridization supports diagnosis, but the real‐world performance of the basic test (lymphocytes and granulocytes) versus the detailed test ...
Nicholas F. DeCleene, Duc T. Nguyen, Susan E. Kirk, Hannah L. Helber, Ghadir S. Sasa, Alison A. Bertuch   +5 more
wiley   +1 more source

Structure-based design of novel naproxen derivatives targeting monomeric nucleoprotein of Influenza A virus

Journal of Biomolecular Structure and Dynamics, 2014
The nucleoprotein (NP) binds the viral RNA genome as oligomers assembled with the polymerase in a ribonucleoprotein complex required for transcription and replication of influenza A virus.
B. Tarus, H. Bertrand, G. Zedda, C. Di Primo, S. Quideau, A. Slama-Schwok   +5 more
semanticscholar   +1 more source

Influenza A Virus (H1N1) Infection Induces Ferroptosis to Promote Developmental Injury in Fetal Tissues

Cell Proliferation, EarlyView.
H1N1 infection during pregnancy specifically targets the fetal liver and lungs, triggering immune responses, tissue fibrosis and ferroptosis in parenchymal cells, ultimately leading to adverse pregnancy outcomes, offering insights into managing maternal H1N1 infections and their impact on fetal health.
Yuxi Jiang, Yao Shen, Qiongyin Zhang, Zi Liu, Yuzhen Liu, Jiaojiao Peng, Xuesong Yang, Feng Gao, Xiang‐Hong Ou, Qing‐Yuan Sun, Qiao Zhang, Guang Wang   +11 more
wiley   +1 more source

Pandemic Influenza A Viruses Escape from Restriction by Human MxA through Adaptive Mutations in the Nucleoprotein

PLoS Pathogens, 2013
The interferon-induced dynamin-like MxA GTPase restricts the replication of influenza A viruses. We identified adaptive mutations in the nucleoprotein (NP) of pandemic strains A/Brevig Mission/1/1918 (1918) and A/Hamburg/4/2009 (pH1N1) that confer MxA ...
B. Mänz, Dominik Dornfeld, Veronika Götz, R. Zell, P. Zimmermann, O. Haller, G. Kochs, M. Schwemmle   +7 more
semanticscholar   +1 more source

Non‐Coding RNAs in Breast Cancer Radioresistance: Mechanisms, Functional Roles and Translational Potentials

Cell Proliferation, EarlyView.
Non‐coding RNAs (ncRNAs) regulate breast cancer radioresistance via cell cycle, DNA repair and tumour microenvironment pathways. Targeting ncRNAs (e.g., HOTAIR and miR‐155) with RNA‐based therapies (ASOs and CRISPR) shows promise but faces delivery challenges.
Xiaohui Zhao, Yuting Qiu, Jie Chen, Danni Wang, Zairui Wang, Shuang Ma, Yimin Liu, Guoying Liu, Zhuofei Bi   +8 more
wiley   +1 more source

Comprehensive Evolutionary and Structural Analysis of the H5N1 Clade 2.4.3.4b Influenza a Virus Based on the Sequences and Data Mining of the Hemagglutinin, Nucleoprotein and Neuraminidase Genes Across Multiple Hosts

Pathogens
H5N1 Influenza A virus continues to pose a significant zoonotic threat, with increasing evidence of interspecies transmission and genetic adaptation. Previous studies primarily focused on avian or human isolates, with limited comprehensive analysis of ...
Kalpana Singh, Yashpal S. Malik, Maged Gomaa Hemida   +2 more
doaj   +1 more source

Molecular Epidemiology of Rabies in Southern People’s Republic of China

Emerging Infectious Diseases, 2009
In recent years, the number of human rabies cases in the People’s Republic of China has increased during severe epidemics in 3 southern provinces (Guizhou, Guangxi, and Hunan).
Xiao-Yan Tao, Qing Tang, Hao Li, Zhao-Jun Mo, Hong Zhang, Ding-Ming Wang, Qiang Zhang, Miao Song, Andres Velasco-Villa, Xianfu Wu, Charles E. Rupprecht, Guo-Dong Liang   +11 more
doaj   +1 more source

SOX30 Governs Synaptonemal Complex Assembly and Homologous Recombination in Male Meiosis

Cell Proliferation, EarlyView.
The transcription factor SOX30 directly binds promoter regions of SYCE1 and SYCE2 to mediate their transcriptional activation, thereby enabling proper assembly of central elements within the synaptonemal complex. Structural destabilisation of the synaptonemal complex in Sox30 KK spermatocytes triggers synaptic discontinuity, impairs homologous ...
Kangle Liu, Wenfeng Zhang, Xiao Jiang, Jianping Chen, Lei Zhu, Zhonghao Zhang, Jing Gu, Lulu Guo, Lin Ao, Qing Chen, Lei Sun, Yuhan Hu, Xin Wang, Yaxin Liu, Jia Cao, Fei Han, Jinyi Liu   +16 more
wiley   +1 more source

The Replication Function of Rabies Virus P Protein Is Regulated by a Novel Phosphorylation Site in the N-Terminal N Protein-Binding Region

Viruses
The rabies virus (RABV) phosphoprotein (P protein) has multiple functions, including acting as the essential non-catalytic cofactor of the viral polymerase (L protein) for genome replication and transcription; the principal viral antagonist of the ...
Ericka Tudhope, Camilla M. Donnelly, Ashish Sethi, Cassandra David, Nicholas Williamson, Murray Stewart, Jade K. Forwood, Paul R. Gooley, Gregory W. Moseley   +8 more
doaj   +1 more source

Short interfering RNA inhibits Rift Valley fever virus replication and degradation of protein kinase R in human cells

Frontiers in Microbiology, 2016
Rift Valley fever virus (RVFV) is a mosquito-borne zoonotic pathogen causing severe outbreaks in humans and livestock in sub-Saharan Africa and the Arabian Peninsula.
Bonto Faburay, Juergen A Richt
doaj   +1 more source