Results 161 to 170 of about 61,031 (268)

Assessing CD8+ T cell cross‐reactivity to influenza A, B and C virus‐derived peptides presented by HLA‐B*18:01

Clinical &Translational Immunology, Volume 15, Issue 10, 2026.
Abstract Objectives Despite the availability of vaccines, influenza viruses still cause substantial morbidity and mortality. This highlights the need for improved vaccines and novel therapeutics. CD8+ T cells recognise conserved viral epitopes and can provide broad protection, making them attractive targets for next‐generation vaccine design.
Lawton D Murdolo, Samuel Liwei Leong, Janesha C Maddumage, Lloyd D'Orsogna, Demetra SM Chatzileontiadou, Emma J Grant, Stephanie Gras   +6 more
wiley   +1 more source

ATF6‐mediated GTPase RHOQ promotes liver cancer progression via enhancing aerobic glycolysis through PAK1 phosphorylation

Clinical and Translational Medicine, Volume 16, Issue 10, October 2026.
• RHOQ is a novel direct transcriptional target of ATF6 in HCC. • High RHOQ expression is associated with unfavourable clinicopathological features and poorer PFS. • RHOQ drives HCC progression via PAK1 activation and aerobic glycolysis. • Combining the PAK1‐specific inhibitor IPA‐3 with GPC3‐targeted CAR T‐cell therapy produces a potent synergistic ...
Yuange Zheng, Wei Li, Yuxin Guo, Xilin Zhu, Ying Liu, Xiaopan Wu   +5 more
wiley   +1 more source

Neutrophil Extracellular Traps (NETs), Immunothrombosis and the Microvascular Siege in Sepsis‐ARDS

Pulmonary Circulation, Volume 16, Issue 4, October 2026.
NET‐driven immunothromboinflammation in sepsis‐associated ARDS. Sepsis‐associated signals activate neutrophils and promote the release of neutrophil extracellular traps (NETs), which form DNA–histone–granular protein scaffolds within the pulmonary microcirculation.
Amr Ali Mohamed Abdelgawwad El‐Sehrawy, Djaloliddin Mansurov, MIRZA R. Baig, Ihab M. Abdelrahim, Neeraj Bainsal, Pankaj Bansal, Sarmad S. Abdullah, Zeina T. Khaleel, Majid S. Jabir, Aseel Smerat   +9 more
wiley   +1 more source

Machine Learning‐Guided Identification of Madecassoside as a Potential RAD51 Modulator That Sensitizes Breast Cancer Cells to Cisplatin

Chemical Biology &Drug Design, Volume 108, Issue 4, October 2026.
Madecassoside was selected from an in‐house natural product library through machine learning‐based virtual screening and identified as a potential modulator of RAD51‐mediated DNA repair that enhances cisplatin sensitivity in breast cancer cells. ABSTRACT Homologous recombination (HR) is an essential pathway for preserving the genomic stability of cells
Minju Oh, Mi‐Young Jeong, Jiwon Choi
wiley   +1 more source

Multi-antigen coronavirus vaccine induces potent and durable cross-protection against multiple SARS-CoV-2 variants. [PDF]

NPJ Vaccines
Prakash S, Dhanushkodi NR, Quadiri A, Vahed H, Chentoufi AA, Coulon PG, Ibraim IC, El Babsiri A, Tifrea DF, Figueroa CJ, Gil D, Ulmer JB, BenMohamed L.   +12 more
europepmc   +1 more source

DNAzymes and Oligodeoxyribonucleotides Immobilized on Aminopropylsilanol and Polylysine‐Anatase Nanoparticles as Active Agents Against Influenza A/H5N1 Virus

Chemical Biology &Drug Design, Volume 108, Issue 4, October 2026.
Scheme of localization of DNAzymes (Dz) and oligonucleotides (ON) on segment 5 of the influenza A/H5N1 virus (A). The nanocomposites based on aminopropylsilanol (Si) and anatase (Ans) nanoparticles bearing Dz and ON effectively inhibit the virus replication in the infected MDCK cells by 2.5–3.5 lg (B).
Marina Repkova, Asya Levina, Ekaterina Filippova, Elena Makarevich, Maria Protsenko, Larisa Shishkina, Artemiy Sergeev, Valentina Zarytova   +7 more
wiley   +1 more source

Unravelling the genomic epidemiology and antigenic evolution of Chandipura virus: A genetically constrained neurotropic threat. [PDF]

PLoS Negl Trop Dis
Kuri PR, Sharma A.
europepmc   +1 more source

Processing of the DRB1*1103-restricted measles virus nucleoprotein determinant 185-199 in the endosomal compartment.

, 1998
MHC class II molecules present to CD4+ T cells protein fragments which mostly derive from the extracellular and from the endosomal compartments. Determinants of cytosolic proteins are, however, also displayed by MHC class II molecules following pathways ...
Muller, C.P., Ammerlaan, W., Fournier, P., Demotz, S., Barbey, C.   +4 more
core  

KU80 suppresses endonuclease G activity to preserve genomic integrity

The FEBS Journal, Volume 293, Issue 19, Page 5952-5966, October 2026.
Under normal conditions, EndoG remains restricted to mitochondria and the genome remains intact. When KU80 is absent, EndoG translocates into the nucleus, where it promotes DNA fragmentation and genomic instability. Thus, this work highlights the importance of KU80 in tightly controlling EndoG localization to preserve genome stability.
Jargalan Batsaikhan, Kwang‐Hyun Park, Hae Ryung Chang, Eunyoung Jung, Myung‐Jin Kim, Jeeyoon Kang, Hyunjo Shim, Eui‐Jeon Woo, Yonghwan Kim   +8 more
wiley   +1 more source

Differences in RNA Binding Between Segmented and Non-Segmented Negative-Strand Virus Nucleocapsids. [PDF]

Microorganisms
Ruigrok RWH, Ballandras-Colas A, Crépin T, Malet H, Kolakofsky D.   +4 more
europepmc   +1 more source