Results 151 to 160 of about 61,031 (268)

Possible roles of HpDML1 in nucleoprotein complex formed by interaction of HpDprA with DNA.

, 2015
Model A: C-C interaction bridges two dimers of HpDprA on DNA and thus allows the protein to oligomerize on DNA. (a)schematic describing the role of C-C interaction restricted to single nucleoprotein filament. (b) outcome of deletion of HpDML1 in nuclease
Kolluru D. Srikanth (764331), Javed Naikoo (764332), Desirazu N. Rao (30944), Gajendradhar R. Dwivedi (764330), Praveen Anand (42856), N. S. Srilatha (764333)   +5 more
core   +1 more source

Hydrostatic pressure activates HIF‐1α via β‐catenin to promote stemness in breast cancer cells

FEBS Open Bio, Volume 16, Issue 10, Page 1992-2002, October 2026.
To mimic the elevated intestinal fluid pressure in breast cancers, we loaded human breast cancer cells (MCF‐7, MDA‐MB‐453, and BT‐474) to 50 mmHg hydrostatic pressure. Hydrostatic pressure exposure upregulated HIF‐1α and induced stemness in MCF‐7 and BT‐474 cells.
Da Zhai, Yong Xu, Jingjing Ma, Ratchanee Duangrat, Chen Yan, Jingyan Liang, Hua Wei, Bin Jiang, Tao‐Sheng Li   +8 more
wiley   +1 more source

Overcoming Transmission Barriers: A Dual‐Functional Adhesive Hydrogel for Direct Monkeypox Virus Neutralization and Wound Healing

Advanced Science, Volume 13, Issue 60, 28 October 2026.
MPXV infection leads to persistent viral replication and severe local inflammation, while existing treatments cannot simultaneously remove viruses and repair injured tissue. This study constructs Polymer@mPDA@Gel hydrogel via a two‐step hierarchical assembly method: mPDA anchors photothermal polymers to form antiviral photothermal subunits, which are ...
Ming Zhang, Jiaxin Tian, Xiaolong Zhu, Xiao Li, Xiangshu Qiu, Yuanyuan Li, Ben Zhong Tang, Ning Shi   +7 more
wiley   +1 more source

Fibrillarin Resists Cellular Senescence Via SIRT1‐Dependent Nicotinamide Metabolism and Its Inhibition Sensitizes Senolytic Therapy in Esophageal Squamous Cell Carcinoma

Advanced Science, Volume 13, Issue 60, 28 October 2026.
FBL directly binds to and stabilizes SIRT1 by blocking its ubiquitin‐proteasome degradation, thereby sustaining nicotinamide metabolism and redox homeostasis to counteract cellular senescence in ESCC. Genetic and pharmacological suppression of FBL sensitizes tumor cells to senolytic therapy.
Xing Jin, Hong Liu, Ling Gao, Lei Liu, Ji‐Bin Liu, Xiaoxia Jin, Ming‐Song Wang, Dan Liu, Li Feng, Wen‐Lian Chen   +9 more
wiley   +1 more source

Human immunogenic T cell epitopes in nucleoprotein of human influenza A (H5N1) virus

, 2012
1. Two novel HLA-A2.1 specific H5N1 nucleoprotein epitopes(NP373-381 AMDSNTLEL and NP458-466 FQGRGVFEL) capable of activating cytotoxic T-cells in vitro were identified. 2.
Cheng, S. C.S., Cheung, Y. K., Ke, Y., Xie, Yong   +3 more
core  

The Cancer Cell Metabolic Reprogramming Remodels the Tumor Microenvironment: Molecular Mechanisms and Therapeutic Strategies

Advanced Science, Volume 13, Issue 58, 19 October 2026.
This review elucidates how cancer cell metabolic reprogramming—across glucose, lipid, amino acid, and nucleotide pathways—remodels the tumor microenvironment to suppress anti‐tumor immunity and promote immune escape. Targeting these metabolic axes offers promising strategies to overcome immunotherapy resistance and enhance cancer treatment.
Guoqing Xiang, Zhicheng Zhou, Xue Jiang, Zhenguang Du, Yangyang Zhan, Xinli Liu   +5 more
wiley   +1 more source

Mitochondria‐Targeted Nanotherapeutics: A Promising Strategy in Modulating Mitochondrial Function, Transfer, and Transplantation

Advanced Science, Volume 13, Issue 58, 19 October 2026.
This review summarizes the pathogenic role of mitochondria in diseases and highlights mitochondrial transfer and transplantation as emerging therapeutic strategies. It systematically discusses how nanomaterials are engineered to facilitate these processes, and critically examines the current challenges and future perspectives for their clinical ...
Yuanyuan Su, Zhiyan Gong, Jiao Mu, Lili Huang, Pengfei Yang, Chenli Zhang, Lingshan Zhao, Liling Yang, Jun Deng, Xiaohui Liao   +9 more
wiley   +1 more source

Taming Mre11–Rad50 at Telomeres: Convergent Strategies for Chromosome‐End Protection Across Evolution

BioEssays, Volume 48, Issue 10, October 2026.
All telomeres must be protected from DNA repair enzymes. This review explores how, from bacteriophages to mammals, unrelated telomere proteins have converged on the same recurring strategies: inhibiting the Mre11–Rad50 nuclease directly or physically shielding DNA ends. ABSTRACT Telomere biology is often framed as a uniquely eukaryotic problem, yet the
Florian Roisné‐Hamelin, Stephan Gruber   +1 more
wiley   +1 more source

In vivo selection and characterization of DNA aptamers against H5N1 virus nucleoprotein

, 2010
OBJECTIVE: To develop DNA aptamers against H5N1 virus nucleoprotein and study the ability to inhibit H5N1 viruses production. METHODS: Nucleoprotein of influenza A virus (A/vietnam1194/2004 (H5N1)) was cloned and expressed in E. coli.
Zheng, B, Lin, Y, Tanner, JA
core  

Investigating CD8 T Cell Exhaustion in Chronic LCMV Infection by Flow Cytometry

Current Protocols, Volume 6, Issue 10, October 2026.
Abstract CD8 T cells and the process of T cell exhaustion are central topics in both basic immunology and translational research, including clinical applications. Here, we provide a comprehensive, step‐by‐step guide to investigate CD8 T cells in murine in vivo lymphocytic choriomeningitis virus (LCMV) infection models.
Dominique Stark, Marie‐Elen Tuchel, Gautier Stehli, Alessandro Genovese, Isaak Quast, Annette Oxenius   +5 more
wiley   +1 more source