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Inhibition of the Type I Interferon Antiviral Response During Arenavirus Infection
Viruses, 2010 Arenaviruses merit interest both as tractable experimental model systems to study acute and persistent viral infections, and as clinically-important human pathogens. Several arenaviruses cause hemorrhagic fever (HF) disease in humans.
Juan Carlos de la Torre +2 more
doaj +1 more source
SARS-CoV-2 IgG seropositivity after the severe Omicron wave of COVID-19 in Hong Kong
Emerging Microbes and Infections, 2022 The SARS-CoV-2 Omicron variant has led to a major wave of COVID-19 in Hong Kong between January and May 2022. Here, we used seroprevalence to estimate the combined incidence of vaccination and SARS-CoV-2 infection, including subclinical infection which ...
Rosana Wing-Shan Poon +12 more
doaj +1 more source
TRIM41-Mediated Ubiquitination of Nucleoprotein Limits Influenza A Virus Infection
Journal of Virology, 2018 Influenza control strategies rely on annual immunization and require frequent updates of the vaccine, which is not always a foolproof process. Furthermore, the current antivirals are also losing effectiveness as new viral strains are often refractory to ...
G. Patil +6 more
semanticscholar +1 more source
mSphere, 2018 Influenza A viruses (IAVs) can cause zoonotic infections with pandemic potential when most of the human population is immunologically naive. After a pandemic, IAVs evolve to become seasonal in the human host by acquiring adaptive mutations.
Isabel Pagani +6 more
doaj +1 more source
Ebola virus VP30 and nucleoprotein interactions modulate viral RNA synthesis [PDF]
, 2017 Ebola virus (EBOV) is an enveloped negative-sense RNA virus that causes sporadic outbreaks with high case fatality rates. Ebola viral protein 30 (eVP30) plays a critical role in EBOV transcription initiation at the nucleoprotein (eNP) gene, with ...
Amarasinghe, Gaya K +6 more
core +2 more sources
CNOT4-Mediated Ubiquitination of Influenza A Virus Nucleoprotein Promotes Viral RNA Replication
mBio, 2017 Influenza A virus (IAV) RNA segments are individually packaged with viral nucleoprotein (NP) and RNA polymerases to form a viral ribonucleoprotein (vRNP) complex.
Yu-Chen Lin +2 more
doaj +1 more source
Frontiers in Immunology, 2023 IntroductionUnderstanding how spike (S)-, nucleoprotein (N)-, and RBD-directed antibody responses evolved in mild and asymptomatic COVID-19 in Africa and their interactions with SARS-CoV-2 might inform development of targeted treatments and vaccines ...
Jennifer Serwanga +31 more
doaj +1 more source
Role of the Schizosaccharomyces pombe F-box DNA helicase in processing recombination intermediates. [PDF]
, 2005 In an effort to identify novel genes involved in recombination repair, we isolated fission yeast Schizosaccharomyces pombe mutants sensitive to methyl methanesulfonate (MMS) and a synthetic lethal with rad2.
Carr, Antony M +6 more
core +2 more sources
The Nucleoprotein and Phosphoprotein of Measles Virus
Frontiers in Microbiology, 2019 Measles virus is a negative strand virus and the genomic and antigenomic RNA binds to the nucleoprotein (N), assembling into a helical nucleocapsid. The polymerase complex comprises two proteins, the Large protein (L), that both polymerizes RNA and caps ...
Serafima Guseva +3 more
semanticscholar +1 more source
THE SPANISH INFLUENZA VIRUS: TREATS TO THE PORTRAIT AFTER 100 YEARS
Инфекция и иммунитет, 2018 The purpose of the study was to compare molecular characteristics of genes and proteins of pandemic influenza strains and find features of the 1918 Spanish influenza virus.
E. P. Kharchenko
doaj +1 more source