Results 51 to 60 of about 47,725 (189)

Live Attenuated Influenza Vaccines engineered to express the nucleoprotein of a recent isolate stimulate human influenza CD8+ T cells more relevant to current infections

Human Vaccines & Immunotherapeutics, 2018
Live attenuated influenza vaccines (LAIV) induce CD8+ T lymphocyte responses that play an important role in killing virus-infected cells. Despite the relative conservation of internal influenza A proteins, the epitopes recognized by T cells can undergo ...
D. Korenkov, T. H. O. Nguyen, I. Isakova-Sivak, T. Smolonogina, L. E. Brown, K. Kedzierska, L. Rudenko   +6 more
doaj   +1 more source

Gut Microbiota‐Derived Extracellular Vesicles in Patients With Obesity Undergoing Gastric Bypass Surgery

Molecular Microbiology, EarlyView.
Extracellular vesicles (EVs) have been suggested to participate in gut microbiota–host communication. While obesity and bariatric surgery have been shown to alter the gut microbiota composition, changes in gut microbiota‐EVs have not been investigated.
Jenni Hekkala, Anna Kaisanlahti, Mysore V. Tejesvi, Jenni Turunen, Nikke Virtanen, Sonja Karikka, Pande Putu Erawijantari, Anatoliy Samoylenko, Genevieve Bart, Seppo Vainio, Leo Lahti, Janne Hukkanen, Terhi Ruuska‐Loewald, Vesa Koivukangas, Justus Reunanen   +14 more
wiley   +1 more source

Nucleoprotein Autoantibodies in Lupus Erythematosus

Journal of Investigative Dermatology, 1985
Autoantibodies against deoxyribonucleic acid (DNA) and ribonucleic acid (RNA) proteins are commonly detected in patients with lupus erythematosus (LE). Antibodies against native DNA are frequently detected in a subset of LE patients with a high prevalence of renal disease.
Provost, Thomas T., Herrera-Esparza, Rafael, Diaz, Luis A.   +2 more
openaire   +2 more sources

A Single‐Base Mutation in TaWAK3‐B Reduces Plant Height via Cytoskeleton in Bread Wheat

Plant Biotechnology Journal, EarlyView.
ABSTRACT Introduction of Reduced height (Rht) genes into modern wheat cultivars has resulted in ‘Green Revolution’ that skyrocketed wheat grain yields worldwide since the 1960s. These ‘Green Revolution’ cultivars show shorter plant height, but higher lodging resistance and harvest index.
Naijiao Wang, Ruolin Bian, Dejie Du, Yunjie Liu, Yiao Ma, Zihao Jiang, Zhaoju Li, Yan Zhou, Xiangyu Zhang, Zhaoheng Zhang, Beilu Cao, Xiongtao Li, Zhaoyan Chen, Jie Liu, Qixin Sun, Zhongfu Ni, Lingling Chai   +16 more
wiley   +1 more source

Identification of lurasidone as a potent inhibitor of severe fever with thrombocytopenia syndrome virus by targeting the viral nucleoprotein

Frontiers in Microbiology
IntroductionSevere fever with thrombocytopenia syndrome virus (SFTSV) is an emerging tick-borne bunyavirus that causes acute febrile illness with thrombocytopenia and a high mortality rate in humans.
Ting Cheng, Qingcui Xiao, Jing Cui, Shuangjie Dong, Yuqin Wu, Wenqiang Li, Xinya Yang, Lina Ma, Zhiyong Li, Zhiyong Li, Zhiyong Li, Peng Sun, Peng Sun, Peng Sun, Yinli Xie, Yinli Xie   +15 more
doaj   +1 more source

Rooting Conifer Genetic Research: An Accessible and Efficient Transformation System

Plant Biotechnology Journal, EarlyView.
ABSTRACT Conifers serve as the cornerstone of global forest ecosystems, yet their genetic transformation faces notorious challenges. To overcome the intrinsic resistance of conifer adventitious roots to Agrobacterium/Rhizobium‐mediated transformation, we systematically and iteratively engineered the binary vector by introducing chimeric Ri plasmid ...
Jing‐Jing Li, Yi‐Mei Zhao, Jia‐Fan Liu, Chen‐He Li, Hui Zhang, Yi‐Tong Song, Quan Zuo, Pei‐Yi Wang, Kai Gao, Dong Meng, Shi‐Hui Niu   +10 more
wiley   +1 more source

Dimerization of Rabies Virus Phosphoprotein and Phosphorylation of Its Nucleoprotein Enhance Their Binding Affinity

Viruses
The dynamic interplay between a multimeric phosphoprotein (P) and polymeric nucleoprotein (N) in complex with the viral RNA is at the heart of the functioning of the RNA-synthesizing machine of negative-sense RNA viruses of the order Mononegavirales.
Euripedes de Almeida Ribeiro, Cédric Leyrat, Francine C. A. Gérard, Marc Jamin   +3 more
doaj   +1 more source

Longitudinal Surveillance of Influenza A Virus Exposure in Wild Boars (Sus scrofa) in Spain (2015–2023): Serologic and Virologic Evidence of Subtype Infections and H5N1 Spillover Risk

Zoonoses and Public Health, EarlyView.
ABSTRACT Introduction Influenza A viruses (IAVs) are responsible for respiratory infections in a wide range of species, including birds, swine and humans. The role of wild boar (Sus scrofa) in IAV epidemiology remains underexplored. Here, we present a longitudinal serologic and virologic surveillance study of wild boars in Spain from 2015 to 2023 ...
Paloma Encinas, Aitor Nogales, Estela Escribano‐Romero, M. Ángeles Martín del Burgo, Jorge Ramón López‐Olvera, José Enrique Granados, Gregorio Mentaberre, Adolfo García‐Sastre, Gustavo del Real   +8 more
wiley   +1 more source

Liquid–Liquid Phase Separation in Viral Infection and Immunology

MedComm, Volume 7, Issue 4, April 2026.
LLPS organizes viral replication and antiviral immunity. Viruses hijack LLPS to form replication factories and evade immune sensors, while hosts assemble LLPS‐driven signaling hubs (e.g., MAVS, RIG‐I, and SGs) to amplify interferon responses. Targeting these condensate interfaces offers novel therapeutic strategies against infectious diseases ...
Jiuzhi Xu, Lan Bai, Bin Wang, Hai Song, Long Zhang, Fangfang Zhou   +5 more
wiley   +1 more source

Hydroxyl radical footprinting modification reveals an intradomain communication pathway in EFL1 disrupted by a Shwachman‐Diamond syndrome‐associated mutation

Protein Science, Volume 35, Issue 4, April 2026.
Abstract Shwachman‐Diamond syndrome (SDS) is a rare genetic disorder characterized by pancreatic insufficiency and neutropenia. While most cases are linked to mutations in the SBDS gene, some involve mutations in the GTPase EFL1. This protein works with SBDS to release the anti‐association factor eIF6 from the 60S ribosomal subunit during ribosome ...
Jonathan A. Zúñiga‐Domínguez, Rohit Jain, Martín González‐Andrade, Erik R. Farquhar, Mark R. Chance, Abril Gijsbers, Nuria Sánchez‐Puig   +6 more
wiley   +1 more source