Results 71 to 80 of about 101,993 (329)

The Antiviral Mechanism of an Influenza A Virus Nucleoprotein-Specific Single-Domain Antibody Fragment

mBio, 2016
Alpaca-derived single-domain antibody fragments (VHHs) that target the influenza A virus nucleoprotein (NP) can protect cells from infection when expressed in the cytosol.
L. Hanke, K. Knockenhauer, R. Brewer, Eline van Diest, F. Schmidt, T. Schwartz, H. Ploegh, Hanke L, Knockenhauer Ke, Brewer R Van Diest, Schmidt Fi, Schwartz Tu, P. Palese   +12 more
semanticscholar   +1 more source

ZNRD2 Mediated Nucleoprotein Aggregation Impairs Respiratory Syncytial Virus Replication

Advanced Science, EarlyView.
During RSV infection, nucleoprotein (N) forms RNA‐bound oligomers. The host protein ZNRD2 binds to these oligomers, promoting their transition into insoluble aggregates. These aggregates simultaneously sequester functional N to restrict viral production and disrupt chaperonin assembly quality control by interfering with ZNRD2's role as an adaptor ...
Haiwu Zhou, Mingbin He, Jinhong Du, Cong Liu, Weiwei Wang, Yuewen Han, Zhifei Li, Yali Qin, Mingzhou Chen   +8 more
wiley   +1 more source

Development of a Luciferase Immunosorbent Assay for Detecting Crimean–Congo Hemorrhagic Fever Virus IgG Antibodies Based on Nucleoprotein

Viruses
Crimean–Congo hemorrhagic fever (CCHF) is a serious tick-borne disease with a wide geographical distribution. Classified as a level 4 biosecurity risk pathogen, CCHF can be transmitted cross-species due to its aerosol infectivity and ability to cause ...
Qi Chen, Yuting Fang, Ning Zhang, Chengsong Wan   +3 more
doaj   +1 more source

Differential Disease Susceptibilities in Experimentally Reptarenavirus-Infected Boa Constrictors and Ball Pythons. [PDF]

, 2017
Inclusion body disease (IBD) is an infectious disease originally described in captive snakes. It has traditionally been diagnosed by the presence of large eosinophilic cytoplasmic inclusions and is associated with neurological, gastrointestinal, and ...
Boback, Scott M, DeRisi, Joseph L, Drazenovich, Tracy, Garcia, Valentina E, Hawkins, Michelle G, Hoon-Hanks, Laura L, Keel, M Kevin, Layton, Marylee L, Sanchez-Migallon Guzman, David, Stenglein, Mark D   +9 more
core   +1 more source

Exaptation of Bornavirus-Like Nucleoprotein Elements in Afrotherians

PLoS Pathogens, 2016
Endogenous bornavirus-like nucleoprotein elements (EBLNs), the nucleotide sequence elements derived from the nucleoprotein gene of ancient bornavirus-like viruses, have been identified in many animal genomes.
Y. Kobayashi, Masayuki Horie, Ayumi Nakano, K. Murata, T. Itou, Yoshiyuki Suzuki   +5 more
semanticscholar   +1 more source

A Lung‐Immune Dual‐Humanized Mouse Using Cryopreserved Tissue Enables Infection and Immune Profiling of Human Common Cold Coronaviruses

Advanced Science, EarlyView.
Cryopreserved lung‐humanized mice overcome the dependency to fresh tissues and permit head‐to‐head profiling of all four human common cold coronaviruses versus SARS‐CoV‐2 infection; the model validates Paxlovid efficacy against HKU1 and, when coupled with human immune‐system engraftment, enables interrogation of lung‐resident human immunity and HKU1 ...
Chunyu Cheng, Jing Sun, Chun Lu, Qian Yu, Yiyun He, Bingqing Wu, Deshan Ren, Shuai Ding, Jincun Zhao, Yan Li   +9 more
wiley   +1 more source

The hnRNP A2B1 is important for the replication of SFTSV and other RNA viruses

Microbiology Spectrum
The heterogeneous nuclear ribonucleoprotein (hnRNP A2B1) is a key component of the hnRNP complex involving RNA modulation in eukaryotic cells and it has also been reported to be involved in the replication of the hepatitis E virus, influenza A virus, and
Xu Zhang, Li-na Yan, Bin-yan Liu, Chuan-min Zhou, Xue-jie Yu   +4 more
doaj   +1 more source

Fusion protein consisting of hemagglutinin small subunit and truncated nucleoprotein as a universal influenza vaccine candidate: Starting in-silico evaluation toward In Vitro expression

Journal of Pharmacy and Bioallied Sciences, 2023
Background: Influenza virus is a respiratory pathogen, which causes high degree of mortality and morbidity during seasonal epidemics and sporadic pandemics.
Fatemeh Morshedi, Elaheh Nazeri, Maryam Saleh, Behrokh Farahmand   +3 more
doaj   +1 more source

Nucleoprotein content of "L" strain of Staphylococcus aureus [PDF]

, 1950
Thesis (M.A.)--Boston ...
Fish, Charles Austin
core   +1 more source

A two-step lyssavirus real-time polymerase chain reaction using degenerate primers with superior sensitivity to the fluorescent antigen test [PDF]

, 2014
A generic two-step lyssavirus real-time reverse transcriptase polymerase chain reaction (qRT-PCR), based on a nested PCR strategy, was validated for the detection of different lyssavirus species.
De Craeye, Stéphane, Francart, Aurélie, Kalai, Michael, Lamoral, Sophie, Nazé, Florence, Suin, Vanessa, Van Gucht, Steven   +6 more
core   +4 more sources