Results 81 to 90 of about 47,725 (189)

MiR-130c-5p targets the SHVV n gene and upregulates immune cytokines (IL-6, IL-22, IL-1β) to inhibit viral replication

Frontiers in Immunology
BackgroundSnakehead vesiculovirus (SHVV) has led to huge economic losses in snakehead aquaculture, and its pathogenic mechanisms is still not fully understood.
Jin Wei, Yan Ji, Yaqian Bai, Rui Cheng, Jiaqi Zhang, Xianqin Hu, Chi Zhang   +6 more
doaj   +1 more source

Functional Evaluation of a Conserved HNH Endonuclease Gene in Lactococcal Skunavirus Genomes

Microbial Biotechnology, Volume 19, Issue 3, March 2026.
The HNH endonuclease HrdP is a highly conserved and essential determinant of infectivity among Skunavirus phages, specifically required for the successful completion of DNA packaging. This key role highlights HrdP as a promising and specific anti‐phage target to protect dairy starter cultures from failure.
Jun‐Hyeok Yu, Frank Hille, Christian Cambillau, Natalia Biere, Arjen Nauta, Charles M. A. P. Franz, Jennifer Mahony, Douwe van Sinderen   +7 more
wiley   +1 more source

Structural disorder within paramyxoviral nucleoproteins

FEBS Letters, 2015
In this review I summarize available data pointing to the abundance of structural disorder within the nucleoprotein (N) from three paramyxoviruses, namely the measles (MeV), Nipah (NiV) and Hendra (HeV) viruses. I provide a detailed description of the molecular mechanisms that govern the disorder‐to‐order transition that the intrinsically disordered C ...
openaire   +4 more sources

The diagnostic performance of the basic versus the detailed telomere Flow FISH test in young patients with aplastic anaemia

British Journal of Haematology, Volume 208, Issue 3, Page 1093-1104, March 2026.
Summary Identifying telomere biology disorders (TBDs) in patients with aplastic anaemia (AA) is essential for guiding appropriate care. Telomere length (TL) measurement by flow cytometry with fluorescence in situ hybridization supports diagnosis, but the real‐world performance of the basic test (lymphocytes and granulocytes) versus the detailed test ...
Nicholas F. DeCleene, Duc T. Nguyen, Susan E. Kirk, Hannah L. Helber, Ghadir S. Sasa, Alison A. Bertuch   +5 more
wiley   +1 more source

Influenza A Virus (H1N1) Infection Induces Ferroptosis to Promote Developmental Injury in Fetal Tissues

Cell Proliferation, Volume 59, Issue 3, March 2026.
H1N1 infection during pregnancy specifically targets the fetal liver and lungs, triggering immune responses, tissue fibrosis and ferroptosis in parenchymal cells, ultimately leading to adverse pregnancy outcomes, offering insights into managing maternal H1N1 infections and their impact on fetal health.
Yuxi Jiang, Yao Shen, Qiongyin Zhang, Zi Liu, Yuzhen Liu, Jiaojiao Peng, Xuesong Yang, Feng Gao, Xiang‐Hong Ou, Qing‐Yuan Sun, Qiao Zhang, Guang Wang   +11 more
wiley   +1 more source

Co‐localization of tau and TDP‐43 after extracellular vesicle delivery to cells

The FEBS Journal, Volume 293, Issue 5, Page 1495-1515, March 2026.
Extracellular vesicles (EVs) derived from donor cells transfected with EGFP–2N4R‐tau or mCherry‐wtTDP‐43 were taken up by recipient cells, leading to cytosolic co‐localization of tau and TDP‐43. Molecular modeling revealed that tau and TDP‐43 directly interact through hydrogen bonding, suggesting a mechanistic link underlying their co‐pathology ...
Farhang Aliakbari, Kathryn Volkening, Zahra Nayeri, Aysegul Yucel Polat, Neil Donison, Jacqueline Palik, Michael J. Strong   +6 more
wiley   +1 more source

Linderalactone mitigates diabetic renal injury by inhibiting macrophage inflammation via the Dectin1/Syk/CARD9/IRF5/NF‐κB pathway

Journal of Diabetes Investigation, Volume 17, Issue 3, Page 395-410, March 2026.
ABSTRACT Background Inflammation plays an essential role in the pathogenesis of diabetic nephropathy (DN). Linderalactone (LNL), as a natural sesquiterpene lactone, has been discovered to have anti‐inflammatory activation. However, the effects of linderalactone on diabetes‐associated renal damage remain unclear.
Hao Chen, Sheng Xu, Bingrong Chen, Xishan Xiong, Jinrui Hu, Yuhong Wu, Tianrui Wang, Huishang Wang   +7 more
wiley   +1 more source

Review of expansion microscopy combined with advanced imaging modalities

Journal of Microscopy, Volume 301, Issue 3, Page 335-354, March 2026.
Abstract Expansion microscopy (ExM) is a powerful high‐resolution imaging technique that enhances the spatial resolution of conventional light microscopy by physically enlarging biological specimens by embedding and cross‐linking them in a swellable polymer network.
Natalie Woo, Claire M. Brown
wiley   +1 more source

Study on the immune enhancers against Micropterus salmoides rhabdovirus infection

Journal of Limnology
Micropterus salmoides rhabdovirus (MSRV) is one of the most serious pathogens harming M. salmoides juvenile, which had brought huge economic losses to farming industry. Studies involving candidate genes to the clinical diseases, however, are limited. In
Ning Lei, Chaonan Zhang, Yanchao Wang, Junjie Zhu   +3 more
doaj   +1 more source

Virus‐Dependent Geographic Structure of Co‐Circulating Viruses in a Single Bat Species

Molecular Ecology, Volume 35, Issue 5, March 2026.
ABSTRACT Understanding the spatial spread of viruses within wildlife populations is often a key component of disease management efforts. Viral spread is likely constrained by host ecology, but inter‐virus differences in infection strategy might allow some viruses to overcome these constraints, leading to divergent population structures within a common ...
Avery L. Holmes, Alice Broos, Daniel J. Becker, Jorge E. Carrera, Maxwell J. Farrell, Rita Ribeiro, Carlos Tello, Laura M. Bergner, Daniel G. Streicker   +8 more
wiley   +1 more source