Results 11 to 20 of about 146,762 (298)
Diversification of 4′-Methylated Nucleosides by Nucleoside Phosphorylases [PDF]
ACS Catalysis, 2021 The growing demand for 4'-modified nucleoside analogs in medicinal and biological chemistry is contrasted by the challenging synthetic access to these molecules and the lack of efficient diversification strategies. Herein, we report the development of a biocatalytic diversification approach based on nucleoside phosphorylases, which allows the ...
Felix Kaspar +11 more
openaire +2 more sources
Sensors, 2006 A rigid molecular clip comprising bisphosphonate binding sites and aromaticsidewalls forming an electron-rich cavity is able to distinguish between nucleosides andnucleotides in aqueous solution. Neutral nucleosides as well as antibiotics derived thereofare drawn into the unpolar interior of the cleft and lead to substantial upfield-shifts in the 1HNMR
Fokkens, Michael +2 more
openaire +2 more sources
Metabolisms of Nucleosides in Bacteria
Agricultural and Biological Chemistry, 1967 Pyrimidine nucleoside phosphorylases obtained from Er. carotovora and Cor. sepedonicum were purified by means of ammonium sulfate fractionation and DEAE-cellulose column chromatography. Some properties of these enzyme were also studied. The enzyme from Cor.
Takuo Sakai +3 more
openalex +7 more sources
Synthesis of Modified Nucleosides [PDF]
Current Protocols in Nucleic Acid Chemistry, 2003 Peer Reviewed ; https://deepblue.lib.umich.edu/bitstream/2027.42/143685/1/cpnc0100 ...
Roger Jones, Piet Herdewijn
openaire +3 more sources
Carbamate-Based Bolaamphiphile as Low-Molecular-Weight Hydrogelators
Gels, 2016 A new bolaamphiphile analog featuring carbamate moieties was synthesized in six steps starting from thymidine. The amphiphile structure exhibits nucleoside-sugar polar heads attached to a hydrophobic spacer via carbamate (urethane) functions.
Laurent Latxague +5 more
doaj +1 more source
Nucleic Acid Sensing by Toll-Like Receptors in the Endosomal Compartment
Frontiers in Immunology, 2022 Toll-like receptors (TLRs) respond to pathogen constituents, such as microbial lipids and nucleic acids (NAs). TLRs recognize NAs in endosomal compartments.
Kensuke Miyake +5 more
doaj +1 more source
Nucleic Acid Based Fluorinated Derivatives: New Tools for Biomedical Applications
Applied Sciences, 2012 Nucleic acid-based fluorinated derivatives, e.g., nucleosides or oligonucleotides connected to highly fluorinated chains or labeled with one or more fluorine atoms, have been investigated recently due to their high potential for biomedical applications ...
Christel Dolain +3 more
doaj +1 more source
Structure Characterization of Escherichia coli Pseudouridine Kinase PsuK
Frontiers in Microbiology, 2022 Pseudouridine (Ψ) is one of the most abundant RNA modifications in cellular RNAs that post-transcriptionally impact many aspects of RNA. However, the metabolic fate of modified RNA nucleotides has long been a question. A pseudouridine kinase (PsuK) and a
Xiaojia Li +7 more
doaj +1 more source
Mechanochemistry of nucleosides, nucleotides and related materials
Beilstein Journal of Organic Chemistry, 2018 The application of mechanical force to induce the formation and cleavage of covalent bonds is a rapidly developing field within organic chemistry which has particular value in reducing or eliminating solvent usage, enhancing reaction rates and also in ...
Olga Eguaogie +4 more
doaj +1 more source