Results 11 to 20 of about 174,887 (292)

Parameterization and Application of the General Amber Force Field to Model Fluoro Substituted Furanose Moieties and Nucleosides

Molecules, 2022
Molecular mechanics force field calculations have historically shown significant limitations in modeling the energetic and conformational interconversions of highly substituted furanose rings. This is primarily due to the gauche effect that is not easily
Diego E. Escalante, Courtney C. Aldrich, David M. Ferguson   +2 more
doaj   +1 more source

Oxalyl retro-peptide gelators. Synthesis, gelation properties and stereochemical effects

Beilstein Journal of Organic Chemistry, 2010
In this work we report on gelation properties, self-assembly motifs, chirality effects and morphological characteristics of gels formed by chiral retro-dipeptidic gelators in the form of terminal diacids (1a–5a) and their dimethyl ester (1b–5b) and ...
Janja Makarević, Milan Jokić, Leo Frkanec, Vesna Čaplar, Nataša Šijaković Vujičić, Mladen Žinić   +5 more
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Advanced Prodrug Strategies in Nucleoside and Non-Nucleoside Antiviral Agents: A Review of the Recent Five Years

Molecules, 2017
Background: Poor pharmacokinetic profiles and resistance are the main two drawbacks from which currently used antiviral agents suffer, thus make them excellent targets for research, especially in the presence of viral pandemics such as HIV and hepatitis ...
Hanadi Sinokrot, Tasneem Smerat, Anas Najjar, Rafik Karaman   +3 more
doaj   +1 more source

Nucleoside Analog 2′,3′-Isopropylidene-5-Iodouridine as Novel Efficient Inhibitor of HIV-1

Pharmaceutics, 2023
Nucleoside reverse transcriptase inhibitors are the first class of drugs to be approved by the FDA for the suppression of HIV-1 and are widely used for this purpose in combination with drugs of other classes.
Ksenia Glumakova, Georgy Ivanov, Valeria Vedernikova, Lena Shyrokova, Timofey Lebedev, Andrei Stomakhin, Anastasia Zenchenko, Vladimir Oslovsky, Mikhail Drenichev, Vladimir Prassolov, Pavel Spirin   +10 more
doaj   +1 more source

Nucleic Acid Based Fluorinated Derivatives: New Tools for Biomedical Applications

Applied Sciences, 2012
Nucleic acid-based fluorinated derivatives, e.g., nucleosides or oligonucleotides connected to highly fluorinated chains or labeled with one or more fluorine atoms, have been investigated recently due to their high potential for biomedical applications ...
Christel Dolain, Amit Patwa, Guilhem Godeau, Philippe Barthélémy   +3 more
doaj   +1 more source

Glycosyl-Nucleolipids as New Bioinspired Amphiphiles

Molecules, 2013
Four new Glycosyl-NucleoLipid (GNL) analogs featuring either a single fluorocarbon or double hydrocarbon chains were synthesized in good yields from azido thymidine as starting material. Physicochemical studies (surface tension measurements, differential
Philippe Barthélémy, Eric Amigues, Amit Patwa, Laurent Latxague   +3 more
doaj   +1 more source

Identification of a Biosynthetic Gene Cluster Responsible for the Production of a New Pyrrolopyrimidine Natural Product—Huimycin

Biomolecules, 2020
Pyrrolopyrimidines are an important class of natural products with a broad spectrum of biological activities, including antibacterial, antifungal, antiviral, anticancer or anti-inflammatory.
Hui Shuai, Maksym Myronovskyi, Suvd Nadmid, Andriy Luzhetskyy   +3 more
doaj   +1 more source

5-aza-2′,2′-Difluoro Deoxycytidine (NUC013): A Novel Nucleoside DNA Methyl Transferase Inhibitor and Ribonucleotide Reductase Inhibitor for the Treatment of Cancer

Pharmaceuticals, 2017
Tumor suppressor genes can be silenced genetically as well as epigenetically. One approach to reversing epigenetic suppression of tumor suppressor genes is to inhibit DNA methyl transferase.
Richard Daifuku, Zhenbo Hu, Yogen Saunthararajah   +2 more
doaj   +1 more source

FTIR, 1H-/13C-NMR spectral characterization, antimicrobial, anticancer, antioxidant, anti-inflammatory, PASS, SAR, and in silico properties of methyl α-D-glucopyranoside derivatives

Chemical Physics Impact
A novel series of biologically active derivatives based on methyl α-D-glucopyranoside (MGP) has been developed, comprising 6-O-monosubstituted MGP derivatives obtained from methyl α-D-glucopyranoside.
Jannatul Ferdous, Faizan Abul Qais, Ferdausi Ali, Debashis Palit, Imtiaj Hasan, Sarkar M.A. Kawsar   +5 more
doaj   +1 more source

Carbamate-Based Bolaamphiphile as Low-Molecular-Weight Hydrogelators

Gels, 2016
A new bolaamphiphile analog featuring carbamate moieties was synthesized in six steps starting from thymidine. The amphiphile structure exhibits nucleoside-sugar polar heads attached to a hydrophobic spacer via carbamate (urethane) functions.
Laurent Latxague, Alexandra Gaubert, David Maleville, Julie Baillet, Michael A. Ramin, Philippe Barthélémy   +5 more
doaj   +1 more source