Advantages of the Parent Nucleoside GS-441524 over Remdesivir for Covid-19 Treatment
ACS Medicinal Chemistry Letters, 2020 While remdesivir has garnered much hope for its moderate anti-Covid-19 effects, its parent nucleoside, GS-441524, has been overlooked. Pharmacokinetic analysis of remdesivir evidences premature serum hydrolysis to GS-441524; GS-441524 is the predominant ...
Victoria C. Yan, F. Muller
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Squalen, 2023 The quality of fish freshness plays a crucial role in the acceptance of consumers and human health. Considering that food safety has recently become a major concern on a global scale, establishing and evaluating fish freshness is crucial for research and
Giri Rohmad Barokah +3 more
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Synthesis of Novel N4-Hydrocytidine Analogs as Potential Anti-SARS-CoV-2 Agents
Pharmaceuticals, 2022 Coronavirus disease 2019 (COVID-19) is an emerging global pandemic with severe morbidity and mortality caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2).
Franck Amblard +11 more
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Purine nucleoside phosphorylase deficiency
Atlas of Inherited Metabolic Diseases, 2020 People with purine nucleoside phosphorylase deficiency have low numbers of immune system cells called T cells, which normally recognize and attack foreign invaders to prevent infection.
C. Staufner
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New Nucleoside Analogues for the Treatment of Hemorrhagic Fever Virus Infections
Chemistry - An Asian Journal, 2019 Eight different compounds, all nucleoside analogues, could presently be considered as potential drug candidates for the treatment of Ebola virus (EBOV) and/or other hemorrhagic fever virus (HFV) infections.
E. De Clercq
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Human immunodeficiency virus rebound after suppression to < 400 copies/mL during initial highly active antiretroviral therapy regimens, according to prior nucleoside experience and duration of suppression [PDF]
, 2002 This study evaluated 1433 human immunodeficiency virus (HIV)-infected patients starting highly active antiretroviral therapy (HAART), 409 (28%) of whom had prior nucleoside experience and achieved an HIV load of
Bickel, M +11 more
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Zika virus protection by a single low dose nucleoside modified mRNA vaccination
Nature, 2017 Zika virus (ZIKV) has recently emerged as a pandemic associated with severe neuropathology in newborns and adults. There are no ZIKV-specific treatments or preventatives.
N. Pardi +36 more
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Phosphorylation of purine and pyrimidine nucleosides by isolated rat liver mitochondria [PDF]
, 1975 Formation of 5'-AMP, 5'-GMP, 5'-CMP and 5'UMP was confirmed in isolated rat liver mitochondria incubated with alpha-ketoglutarate, inorganic phosphate, purine nucleoside and pyrimidine nucleoside. Increased incorporation of 32Pi into ATP, GTP and UTP was
Inaba, Kozo, Oda, Takuzo
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New England Journal of Medicine, 1997 BACKGROUND The efficacy and safety of adding a protease inhibitor to two nucleoside analogues to treat human immunodeficiency virus type 1 (HIV-1) infection are not clear.
S. Hammer +17 more
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Recent Advances in the Chemical Synthesis and Evaluation of Anticancer Nucleoside Analogues
Molecules, 2020 Nucleoside analogues have proven to be highly successful chemotherapeutic agents in the treatment of a wide variety of cancers. Several such compounds, including gemcitabine and cytarabine, are the go-to option in first-line treatments.
Mieke Guinan +3 more
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