Results 11 to 20 of about 340,942 (336)

Lyophilization provides long-term stability for a lipid nanoparticle-formulated, nucleoside-modified mRNA vaccine

Molecular Therapy, 2022
Lipid nanoparticle (LNP)-formulated nucleoside-modified mRNA vaccines have proven to be very successful in the fight against the coronavirus disease 2019 (COVID-19) pandemic. They are effective, safe, and can be produced in large quantities. However, the
Hiromi Muramatsu, Kieu Lam, Csaba Bajusz, Dorottya Laczkó, K. Karikó, Petra Schreiner, Alan D. Martin, P. Lutwyche, J. Heyes, N. Pardi   +9 more
semanticscholar   +1 more source

Broad-Spectrum Antiviral Strategies and Nucleoside Analogues

Viruses, 2021
The emergence or re-emergence of viruses with epidemic and/or pandemic potential, such as Ebola, Zika, Middle East Respiratory Syndrome (MERS-CoV), Severe Acute Respiratory Syndrome Coronavirus 1 and 2 (SARS and SARS-CoV-2) viruses, or new strains of ...
R. Geraghty, M. Aliota, L. Bonnac
semanticscholar   +1 more source

A Single Immunization with Nucleoside-Modified mRNA Vaccines Elicits Strong Cellular and Humoral Immune Responses against SARS-CoV-2 in Mice

Immunity, 2020
SARS-CoV-2 infection has emerged as a serious global pandemic. Because of the high transmissibility of the virus and the high rate of morbidity and mortality associated with COVID-19, developing effective and safe vaccines is a top research priority ...
Dorottya Laczkó, Michael J. Hogan, Sushila A. Toulmin, Philip D. Hicks, Katlyn Lederer, Brian T. Gaudette, Diana Castaño, F. Amanat, Hiromi Muramatsu, Thomas H. Oguin, Amrita Ojha, Lizhou Zhang, Z. Mu, R. Parks, Tomaz B. Manzoni, Brianne Roper, Shirin Strohmeier, I. Tombácz, Leslee Arwood, Raffael Nachbagauer, K. Karikó, J. Greenhouse, Laurent Pessaint, Maciel Porto, Tammy Putman-Taylor, Amanda Strasbaugh, Tracey-Ann Campbell, Paulo J C Lin, Ying K. Tam, G. Sempowski, M. Farzan, H. Choe, K. Saunders, B. Haynes, H. Andersen, L. Eisenlohr, D. Weissman, F. Krammer, Paul Bates, D. Allman, M. Locci, N. Pardi   +41 more
semanticscholar   +1 more source

A Multi-Targeting, Nucleoside-Modified mRNA Influenza Virus Vaccine Provides Broad Protection in Mice.

Molecular Therapy, 2020
Influenza viruses are respiratory pathogens of public health concern worldwide with up to 650,000 deaths occurring each year. Seasonal influenza virus vaccines are employed to prevent disease, but with limited effectiveness.
Alec W. Freyn, Jamile Ramos da Silva, Victoria C. Rosado, C. Bliss, Matthew Pine, B. Mui, Ying K. Tam, T. D. Madden, Luís Carlos de Souza Ferreira, D. Weissman, F. Krammer, Lynda Coughlan, P. Palese, N. Pardi, Raffael Nachbagauer   +14 more
semanticscholar   +1 more source

Antiviral nucleoside analogs

Chemistry of Heterocyclic Compounds, 2021
The minireview surveys the modification of native nucleosides as a result of which huge libraries of nucleoside analogs of various structures were synthesized.
V. Kataev, B. Garifullin
semanticscholar   +1 more source

Parameterization and Application of the General Amber Force Field to Model Fluoro Substituted Furanose Moieties and Nucleosides

Molecules, 2022
Molecular mechanics force field calculations have historically shown significant limitations in modeling the energetic and conformational interconversions of highly substituted furanose rings. This is primarily due to the gauche effect that is not easily
Diego E. Escalante, Courtney C. Aldrich, David M. Ferguson   +2 more
doaj   +1 more source

Phosphorylation of purine and pyrimidine nucleosides by isolated rat liver mitochondria [PDF]

, 1975
Formation of 5'-AMP, 5'-GMP, 5'-CMP and 5'UMP was confirmed in isolated rat liver mitochondria incubated with alpha-ketoglutarate, inorganic phosphate, purine nucleoside and pyrimidine nucleoside. Increased incorporation of 32Pi into ATP, GTP and UTP was
Inaba, Kozo, Oda, Takuzo
core   +1 more source

Purine nucleoside phosphorylase: A new marker for free oxygen radical injury to the endothelial cell [PDF]

, 1990
The effect of ischemia and reperfusion on purine nucleoside phosphorylase was studied in an isolated perfused rat liver model. This enzyme is localized primarily in the cytoplasm of the endothelial and Kupffer cells; some activity is associated with the ...
Abouna, Adkison, Eiseman, Granger, Green, Hanks, Hoffee, James T. Snyder, Kamada, Kamiike, Kamiike, Kizaki, Lanir, Lee, Lee, LeMasters, LeMasters, Leonard Makowka, Marotto, Marubayashi, Marubayashi, McCord, Nishida, Parks, Prakash N. Rao, Randy S. Rubin, Rubio, Teperman, Thomas E. Starzl, Thomas R. Walsh, Thomas Weber, Turner, Van Thiel   +32 more
core   +1 more source

Zika virus protection by a single low dose nucleoside modified mRNA vaccination

Nature, 2017
Zika virus (ZIKV) has recently emerged as a pandemic associated with severe neuropathology in newborns and adults. There are no ZIKV-specific treatments or preventatives.
N. Pardi, Michael J. Hogan, R. S. Pelc, Hiromi Muramatsu, H. Andersen, C. DeMaso, Kimberly A. Dowd, Laura L. Sutherland, R. Scearce, R. Parks, Wendeline Wagner, A. Granados, J. Greenhouse, Michelle Walker, Elinor Willis, J. Yu, C. McGee, G. Sempowski, B. Mui, Ying K. Tam, Yan-Jang S. Huang, D. Vanlandingham, Veronica M. Holmes, H. Balachandran, S. Sahu, M. Lifton, S. Higgs, S. Hensley, T. D. Madden, M. Hope, K. Karikó, S. Santra, B. Graham, M. Lewis, T. Pierson, B. Haynes, D. Weissman   +36 more
semanticscholar   +1 more source

Purine nucleoside phosphorylase deficiency

Atlas of Inherited Metabolic Diseases, 2020
People with purine nucleoside phosphorylase deficiency have low numbers of immune system cells called T cells, which normally recognize and attack foreign invaders to prevent infection.
C. Staufner
semanticscholar   +1 more source