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Synthesis of Thiaazaheterocycle Nucleoside Analogues.

ChemInform, 2002
AbstractFor Abstract see ChemInform Abstract in Full Text.
A, Ané   +6 more
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Biosynthesis of nucleoside analogues via thermostable nucleoside phosphorylase

Applied Microbiology and Biotechnology, 2012
Biocatalyzed synthesis of nucleoside analogues was carried out using two thermostable nucleoside phosphorylases from the hyperthermophilic aerobic crenarchaeon Aeropyrum pernix K1. The synthesis of the 2,6-diaminopurine nucleoside and 5-methyluridine was used as a reaction model to test the process.
Shaozhou, Zhu   +6 more
openaire   +2 more sources

Pyrazolylboratozinc Complexes of Nucleosides and Nucleoside Analogues

European Journal of Inorganic Chemistry, 2003
AbstractAttachment of deprotonated nucleosides or of alkylated nucleobases, as their analogues, to zinc was achieved by condensation reactions between TpZn‐OH complexes and nucleobase derivatives. Pyrazolylboratozinc complexes with derivatives of uracil, thymine, guanine, xanthine and hypoxanthine were obtained and characterized by structure ...
Dirk Badura, Heinrich Vahrenkamp
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Diazine Nucleoside Analogues

ChemInform, 2007
AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
openaire   +1 more source

Phosphonated Nucleoside Analogues

2013
Chemical Synthesis of Nucleoside Analogues examines the application of synthetic methodologies to the preparation of compounds of biological interest, including the synthesis of nucleic acids on pre-existing nucleic acid templates, assembling RNA, or DNA.
Romeo Roberto   +3 more
openaire   +2 more sources

New cycloheptane nucleoside analogues

Mendeleev Communications, 2015
Epoxidation of 1-phenylcyclohept-4-ene-1-carbonitrile gives mostly E-isomer of the desired epoxy derivative, whose ring opening with adenine or thymine proceeds stereoselectively providing access to novel cycloheptane nucleoside analogues.
Aleksandr I. Tsybin   +1 more
openaire   +1 more source

6-Bromopurine Nucleosides as Reagents for Nucleoside Analogue Synthesis

The Journal of Organic Chemistry, 2001
Surprisingly facile direct substitution reactions with acetyl-protected 6-bromopurine nucleosides are described. Included in the series of bromonucleosides studied is the guanosine derivative N(2)-2',3',5'-tetraacetyl-6-bromopurine ribonucleoside, the synthesis of which is reported here for the first time. Brominated nucleosides had not previously been
E A, Véliz, P A, Beal
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Fascinating Transformation of SAM-Competitive Protein Methyltransferase Inhibitors from Nucleoside Analogues to Non-Nucleoside Analogues

Journal of Medicinal Chemistry, 2022
The abnormal expression of protein methyltransferase (PMT) has been linked with many diseases such as diabetes, neurological disorders, and cancer. S-Adenyl-l-methionine (SAM) is a universal methyl donor and gets converted to S-adenyl-l-homocysteine (SAH), an endogenous competitive inhibitor of SAM.
Arindam Talukdar   +2 more
openaire   +2 more sources

Solid-Phase Synthesis of Nucleoside Analogues

Journal of Combinatorial Chemistry, 2003
The synthesis of a 25 000 member library of nucleoside analogues as discrete compounds in milligram quantities is described. The use of the Nanokan technology developed by IRORI (Discovery Partners International) together with macroporous solid support allowed us to develop a highly reliable and practical synthetic route for the high-throughput ...
Robert, Epple   +2 more
openaire   +2 more sources

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