Results 151 to 160 of about 42,345 (197)

Asymmetric Synthesis of 1,3‐Dithiolane Nucleoside Analogues. [PDF]

ChemInform, 2002
AbstractFor Abstract see ChemInform Abstract in Full Text.
CAPUTO, ROMUALDO, GUARAGNA, ANNALISA, PALUMBO, GIOVANNI, PEDATELLA, SILVANA   +3 more
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Tricyclic nucleoside analogues as antiherpes agents

Antiviral Research, 2006
Tricyclic (T) guanine analogues are a class of compounds in which the N1 and N(2) atoms of the guanine system are linked by etheno bridge to form the 3,9-dihydro-9-oxo-5H-imidazo[1,2-a]purine system. Almost 70 tricyclic derivatives of guanine-type potent antiherpetic agents acyclovir (ACV), ganciclovir (GCV) and 9-{[cis-1',2'-bis(hydroxymethyl ...
Bozenna, Golankiewicz, Tomasz, Ostrowski
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Drug Resistance to Cytotoxic Nucleoside Analogues

Current Drug Targets, 2003
Nucleoside analogues are widely used for the treament of hematological malignancies and solid tumors. Their activity is based on the interference with cellular targets involved in the metabolism of physiological nucleosides and DNA synthesis. Unfortunately, various resistance mechanisms decrease the activity of these drugs, reducing their clinical ...
L, Jordheim, C M, Galmarini, C, Dumontet
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Pyrrolidine analogues of nucleosides and nucleotides

Nucleic Acids Symposium Series, 2008
Among the structurally diverse nucleoside phosphonic acids, several compounds possessing strong antiviral properties have been found. Our effort in this area was focused to the synthesis of novel compounds - pyrrolidine-based nucleoside phosphonic acids and their derivatives.
Dominik, Rejman, Radek, Pohl, Sona, Kovacková, Petr, Kocalka, Alzbĕta, Svenková, Hana, Sanderová, Libor, Krásný, Ivan, Rosenberg   +7 more
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Asymmetric Synthesis of Cyclohexene Nucleoside Analogues

The Journal of Organic Chemistry, 2011
The asymmetric synthesis of novel cyclohexene nucleoside analogues 12 and 15 is described. An enantiospecific Diels-Alder reaction between (E,E)-diene 2 and (+)-5-(d-mentyloxy)-2(5H)-furanone 3 provided the cycloadduct isomer 4. Three additional steps yielded amine 8 allowing the constructions of the thymine and adenine moieties to afford intermediates
Dalençon, Sylvain, Ait Youcef, Ramzi, Pipelier, Muriel, Maisonneuve, Vincent, Dubreuil, Didier, Huet, François, Legoupy, Stéphanie   +6 more
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Dendrimers as nanocarriers for nucleoside analogues

European Journal of Pharmaceutics and Biopharmaceutics, 2017
Dendrimers constitute a class of hyperbranched macromolecules with several potential applications due to their unique properties such as a well-defined structure, multivalency and biocompatibility. These polymers became one of the most promising drug nanocarriers, providing improved solubility of therapeutics, high loading capacity and controllable ...
Michał, Gorzkiewicz, Barbara, Klajnert-Maculewicz   +1 more
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Comparative Pharmacokinetics of Antiviral Nucleoside Analogues

Clinical Pharmacokinetics, 1993
The recent development of nucleoside analogues with antiviral activity has expanded the small but useful armamentarium for the treatment of certain viral diseases such as the human immunodeficiency virus, cytomegalovirus and others. Their intracellular site of action and need for sequential phosphorylation require that traditional pharmacokinetic ...
G D, Morse, M J, Shelton, A M, O'Donnell
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Nucleoside Analogues from Branched-Chain Pyranosides

Australian Journal of Chemistry, 2005
Reaction of (pyranosid-3-yl)ethanal 2 with ethynylmagnesium bromide or lithium phenylacetylide in THF afforded (2R,S)-1-(methyl 2-O-benzyl-4,6-O-benzylidene-3-deoxy-α-d-altropyranosid-3-yl)but-3-yn-2-ols 3a and 3b, respectively. Oxidation of 3a and 3b yielded the 1-(methyl 2-O-benzyl-4,6-O-benzylidene-3-deoxy-α-d-altropyranosid-3-yl)but-3-yn-2-ones ...
Iran Otero, Holger Feist, Lidcay Herrera, Manfred Michalik, Jose Quincoces, Klaus Peseke   +5 more
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Nucleoside analogues for chronic hepatitis B

European Journal of Gastroenterology & Hepatology, 2001
Hepatitis B virus replicates inside the hepatocyte through an intermediate step of reverse transcription mediated by the viral polymerase. We describe five nucleoside/nucleotide analogues that interfere with the replication mechanisms of the hepatitis B virus.
Wolters, LMM (Leonieke), Niesters, HGM, de Man, Rob   +2 more
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Nucleosides and Nucleoside Analogues as Emerging Antiviral Drugs

Mini-Reviews in Organic Chemistry, 2021
Nucleosides and their analogues have been in use for many years and have become essential for treating patients with viral infections. Many additional nucleoside drugs have been approved over the past decades. This strongly demonstrates how important these compounds are and the crucial role they play.
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