Results 31 to 40 of about 1,553 (134)

Non‐canonical nitric oxide signalling and DNA methylation: Inflammation induced epigenetic alterations and potential drug targets

British Journal of Pharmacology, Volume 183, Issue 1, Page 24-39, January 2026.
Abstract DNA methylation controls DNA accessibility to transcription factors and other regulatory proteins, thereby affecting gene expression and hence cellular identity and function. As epigenetic modifications control the transcriptome, epigenetic dysfunction is strongly associated with pathological conditions and ageing.
Christopher H. Switzer
wiley   +1 more source

Bacterial cytidine deaminases as versatile activators of fluoropyrimidine nucleoside prodrugs

European Journal of Medicinal Chemistry
A platform for modification of 5-fluoropyrimidine nucleosides as potential prodrugs has been developed utilizing bacterial-derived cytidine deaminases (CDAs) for activation. It has been demonstrated that CDA_EH, CDA_F14, and CDA_Lsp effectively convert 5-fluoropyrimidine analogs into 5-fluoro-(2′-deoxy)uridine exhibiting cytotoxic effects.
Preitakaitė, Viktorija, Kazlauskas, Arūnas, Aučynaitė, Agota, Butkutė, Kamilė, Lapinskaitė, Ringailė, Urbelienė, Nina, Laurynėnas, Audrius, Meškys, Rolandas   +7 more
openaire   +2 more sources

Adenosine Deaminase, Nucleoside Phosphorylase and Xanthine Oxidase in Liver Tumours [PDF]

British Journal of Cancer, 1957
E, REID, I, LEWIN
openaire   +2 more sources

Studies on Nucleoside Deaminase

Journal of Biological Chemistry, 1973
Rose Meyers, V.G. Malathi, Rody P. Cox, Robert Silber   +3 more
openaire   +1 more source

Abstracts

Cancer Science, Volume 117, Issue S1, Page 1-2148, January 2026.
wiley   +1 more source

Inhibition of adenosine deaminase and nucleoside transport

The Journal of Thoracic and Cardiovascular Surgery, 1993
Anwar S. Abd-Elfattah, Robert H. Messier, Patrick W. Domkowski, Janice L. Jones, Hamdy M. Aly, Donald G. Crescenzo, Robert B. Wallace, Richard A. Hopkins   +7 more
openaire   +1 more source

Editing mitochondrial and chloroplast genomes : Genome editing technologies for plant organelles provide new opportunities in functional genomics and breeding. [PDF]

EMBO Rep
Forner J, Bock R.
europepmc   +1 more source

Structural basis for the substrate specificity of Helix pomatia AMP deaminase and a chimeric ADGF adenosine deaminase. [PDF]

J Biol Chem
Kaur G, Horton JR, Tzertzinis G, Zhou J, Schildkraut I, Cheng X.   +5 more
europepmc   +1 more source

Metabolism of Epigenetic Ribonucleosides Leads to Nucleolar Stress and Cytotoxicity. [PDF]

ACS Chem Biol
Sun X, Donlic A, Boyer JA, Press TE, Kim M, Reddy NK, Brangwynne CP, Rabinowitz JD, Kleiner RE.   +8 more
europepmc   +1 more source

Distinct Phage-Encoded Enzymes for Substitution of Deoxythymidine by Deoxyuridine in Phage Genomes. [PDF]

Adv Sci (Weinh)
Li Y, Tan J, Tu Y, Wu J, Zhang Z, Wei Y, Jiao X, Zhou Y.   +7 more
europepmc   +1 more source