Results 31 to 40 of about 2,623 (158)

Maize haplotype with a helitron-amplified cytidine deaminase gene copy [PDF]

, 2006
BACKGROUND: Genetic maps are based on recombination of orthologous gene sequences between different strains of the same species. Therefore, it was unexpected to find extensive non-collinearity of genes between different inbred strains of maize ...
A Gallavotti, A Ohwada, B Han, B Scherrer, C Du, C Rada, CA Mullen, CE Hegeman, F Rodriguez-Trelles, H Fu, HK Dooner, J Lai, J Lai, J Ma, J Messing, J Vieira, JD Thompson, Jian-Hong Xu, Joachim Messing, K Ilic, KH Wolfe, M Morgante, M Nei, MC Timmermans, MD Gale, N Jiang, N Navaratnam, ON Danilevskaya, P Thuriaux, R Bock, R Bruggmann, R Ono, R Song, R Song, R Song, R Song, S Brunner, S Gupta, SD Mahan, SE Faivre-Nitschke, SF Altschul, SK Lal, SK Petersen-Mahrt, SO Freytag, T Doi, VV Kapitonov, WA Wilson, WM Nelson, Z Swigonova   +48 more
core   +3 more sources

In-vivo mutation rates and fitness landscape of HIV-1

, 2016
Mutation rates and fitness costs of deleterious mutations are difficult to measure in vivo but essential for a quantitative understanding of evolution. Using whole genome deep sequencing data from longitudinal samples during untreated HIV-1 infection, we
Albert, Jan, Brodin, Johanna, Neher, Richard, Puller, Vadim, Zanini, Fabio   +4 more
core   +1 more source

Cordyceps sinensis (CS) Alleviates Chronic Obstructive Pulmonary Disease Symptoms (COPD) by Targeting Inflammation, Apoptosis, and Oxidative Stress Through Ingredient–Gene–Disease Interaction

Immunity, Inflammation and Disease, Volume 13, Issue 12, December 2025.
Our findings indicate that Cordyceps Sinensis (CS) alleviates COPD symptoms by inhibiting inflammation and oxidative stress, with key biomarkers such as interleukins (ILs), tumor necrosis factor (TNF), and reactive oxygen species (ROS) identified. Activating autophagy serves as a protective mechanism against COPD development induced by oxidative stress.
Zirui Zang, Yuhan Kong, Qi Kong
wiley   +1 more source

APOBEC3G expression is dysregulated in primary HIV-1 infection and polymorphic variants influence CD4+ T-cell counts and plasma viral load [PDF]

, 2010
OBJECTIVES: In the absence of HIV-1 virion infectivity factor (Vif), cellular cytosine deaminases such as apolipoprotein B mRNA-editing enzyme catalytic polypeptide-like 3G (APOBEC3G) inhibit the virus by inducing hypermutations on viral DNA, among other
Abdool Karim, Salim, Mlisana, Koleka P., Ndung'u, Thumbi, Reddy, Kavidha, Werner, Lise, Winkler, Cheryl A.   +5 more
core   +2 more sources

Genomic and Metabolic Characterization of a Potentially Novel Paenibacillus Species Isolated as a Laboratory Contaminant Growing on Medium Supporting Cotton Tissue Culture

MicrobiologyOpen, Volume 14, Issue 6, December 2025.
This study explores the genomic and metabolic characterization of a potentially novel Paenibacillus species isolated from cotton plant tissues. Phylogenetic analysis based on multi‐locus sequence data from six conserved genes reveals that Paenibacillus sp. TAB_01 forms a distinct lineage among 19 Paenibacillus species. Paenibacillus sp.
Ilksen Topcu, Shravan Sharma Parunandi, Tristan Andrew Gregory, LeAnne M. Campbell, Keerti Rathore, Sanjay Antony‐Babu   +5 more
wiley   +1 more source

Adenosine Deaminating/ Hydrolyzing Enzymes from Alaska pea seeds (Pisum sativum) [PDF]

, 2017
Nucleoside deaminases and nucleoside hydrolases are essential within the purine salvage pathway to recycle purine bases to promote cellular functions such as DNA synthesis, cytokinin metabolism, and more.
Thicklin, Lendsey Breanna
core   +4 more sources

Genetic variability in adenosine deaminase-like contributes to variation in alcohol preference in mice. [PDF]

, 2017
BACKGROUND: A substantial part of the risk for alcohol use disorder (AUD) is determined by genetic factors. We previously used chromosome substitution (CSS) mice, to identify a QTL for alcohol preference on mouse chromosome 2.
Bailey, A, Lesscher, HMB, Vanderschuren, LJMJ   +2 more
core   +1 more source

Targeting Metabolic Reprogramming in Tumor: From Mechanisms to Precision Immunotherapies

MedComm – Oncology, Volume 4, Issue 4, December 2025.
Cancer metabolic reprogramming is a key hallmark of tumorigenesis and antitumor immunity. It boosts tumor progression by enhancing cancer cell fitness in hostile microenvironments and facilitates immune evasion by evading natural and therapy‐driven antitumor immune responses.
Tong Zhang, Ping Gao, Linchong Sun
wiley   +1 more source

The Concise Guide to PHARMACOLOGY 2025/26: Enzymes

British Journal of Pharmacology, Volume 182, Issue S1, Page S307-S403, December 2025.
The Concise Guide to Pharmacology 2025/26 marks the seventh edition in this series of biennial publications in the British Journal of Pharmacology. Presented in landscape format, the guide provides a comparative overview of the pharmacology of drug target families. The concise nature of the Concise Guide refers to the style of presentation, being clear,
Stephen P. H. Alexander, Doriano Fabbro, Alasdair J. Gibb, Eamonn Kelly, Alistair A. Mathie, Chloe J. Peach, Emma L. Veale, Jane F. Armstrong, Elena Faccenda, Simon D. Harding, Christopher Southan, Jamie A. Davies, Stephanie Annett, Detlev Boison, Kathryn Elisa Burns, Carmen Dessauer, Jürg Gertsch, Nuala Ann Helsby, Angelo A. Izzo, Rennolds Ostrom, Ester Pagano, Andreas Papapetropoulos, Nigel J. Pyne, Susan Pyne, Tracy Robson, Roland Seifert, Johannes‐Peter Stasch, Csaba Szabo, Mario van der Stelt, Albert van der Vliet, Val Watts, Szu Shen Wong   +31 more
wiley   +1 more source

140 Reversing the Epidemic of HIV-1C in Southern Africa with Treatment as Prevention [PDF]

, 2014
The epidemic of HIV-1C in southern Africa is characterized by a sustained prevalence that is substantially higher than for other epidemics of HIV/AIDS. Perhaps the best correlate of transmission is high viral load (HVL), which we target to prevent spread
Essex, M.
core   +1 more source