Results 31 to 40 of about 2,632 (160)

Increased Excretion of Modified Adenine Nucleosides by Children with Adenosine Deaminase Deficiency [PDF]

Pediatric Research, 1982
We have identified seven adenine nucleosides in urines of untreated adenosine deaminase (ADA) deficient patients, four of which (adenosine, 2'-deoxyadenosine, 1-methyladenosine and N6-methyladenosine) have been previously identified in urines of normals and/or ADA deficient patients.
R, Hirschhorn, H, Ratech, A, Rubinstein, P, Papageorgiou, H, Kesarwala, E, Gelfand, V, Roegner-Maniscalco   +6 more
openaire   +2 more sources

DNA methyltransferase inhibitors in hematological malignancies and solid tumors

International Journal of Cancer, Volume 158, Issue 2, Page 433-461, 15 January 2026.
Abstract Epigenetic modifications such as DNA methylation play a fundamental role in oncogenesis and the progression of neoplasms neoplasias. DNA methyltransferase inhibitors (DNMTi) constitute a family of therapeutic agents that impede the methylation at the 5‐position on cytosine nucleotides, thereby modulating the epigenetic regulation of tumor ...
Valentin Wenger, Guillermo Garcia‐Manero, Robert Zeiser, Michael Lübbert   +3 more
wiley   +1 more source

Adenosine Deaminase Deficiency and Purine Nucleoside Phosphorylase Deficiency in Common Variable Immunodeficiency [PDF]

Clinical Diagnostic Laboratory Immunology, 1998
ABSTRACTThe clinical presentations of adenosine deaminase deficiency and purine nucleoside phosphorylase deficiency are widely variable and include clinical and immunologic findings compatible with common variable immunodeficiency. The screening of 44 patients with common variable immunodeficiency failed to identify any individuals with deficiencies of
A, Fleischman, M S, Hershfield, S, Toutain, H M, Lederman, K E, Sullivan, M B, Fasano, J, Greene, J A, Winkelstein   +7 more
openaire   +2 more sources

CSN6 Promotes Pancreatic Cancer Progression and Gemcitabine Resistance via Antagonizing DCAF1‐Mediated Ubiquitination of NPM1

Advanced Science, Volume 13, Issue 1, 5 January 2026.
COP9 signalosome subunit 6 (CSN6) promotes the auto‐ubiquitination and degradation of DDB1‐CUL4 associated factor 1 (DCAF1), thereby antagonizing DCAF1‐mediated ubiquitination of Nucleophosmin (NPM1). This stabilization of NPM1 enhances the ribosome biogenesis process and the translation of specific gemcitabine‐resistance proteins, ultimately driving ...
Yijing Zhang, Han Gao, Aiwen Tang, Haiwen Lyu, Zongmin Fan, Jiahui Guo, Yuzhi Wang, Hairong Yi, Qihao Pan, Haidan Luo, Baifu Qin, Boyu Zhang, Xiangqi Meng, Qingxin Liu, Mong‐Hong Lee   +14 more
wiley   +1 more source

Metabolism‐Regulating Nanomedicines for Cancer Therapy

Advanced NanoBiomed Research, Volume 6, Issue 1, January 2026.
This review highlights metabolism‐regulating nanomedicines designed to target glycolytic, lipid, amino acid, and nucleotide pathways in tumors. By incorporating metabolism‐regulating agents into versatile nanocarriers such as liposomes, micelles, dendrimers, and engineered bacteria, these platforms achieve targeted delivery, controlled release ...
Xiao Wu, Shiyi Geng, Jian Yang
wiley   +1 more source

APOBEC3G expression is dysregulated in primary HIV-1 infection and polymorphic variants influence CD4+ T-cell counts and plasma viral load [PDF]

, 2010
OBJECTIVES: In the absence of HIV-1 virion infectivity factor (Vif), cellular cytosine deaminases such as apolipoprotein B mRNA-editing enzyme catalytic polypeptide-like 3G (APOBEC3G) inhibit the virus by inducing hypermutations on viral DNA, among other
Abdool Karim, Salim, Mlisana, Koleka P., Ndung'u, Thumbi, Reddy, Kavidha, Werner, Lise, Winkler, Cheryl A.   +5 more
core   +2 more sources

Non‐canonical nitric oxide signalling and DNA methylation: Inflammation induced epigenetic alterations and potential drug targets

British Journal of Pharmacology, Volume 183, Issue 1, Page 24-39, January 2026.
Abstract DNA methylation controls DNA accessibility to transcription factors and other regulatory proteins, thereby affecting gene expression and hence cellular identity and function. As epigenetic modifications control the transcriptome, epigenetic dysfunction is strongly associated with pathological conditions and ageing.
Christopher H. Switzer
wiley   +1 more source

In-vivo mutation rates and fitness landscape of HIV-1

, 2016
Mutation rates and fitness costs of deleterious mutations are difficult to measure in vivo but essential for a quantitative understanding of evolution. Using whole genome deep sequencing data from longitudinal samples during untreated HIV-1 infection, we
Albert, Jan, Brodin, Johanna, Neher, Richard, Puller, Vadim, Zanini, Fabio   +4 more
core   +1 more source

Maize haplotype with a helitron-amplified cytidine deaminase gene copy [PDF]

, 2006
BACKGROUND: Genetic maps are based on recombination of orthologous gene sequences between different strains of the same species. Therefore, it was unexpected to find extensive non-collinearity of genes between different inbred strains of maize ...
A Gallavotti, A Ohwada, B Han, B Scherrer, C Du, C Rada, CA Mullen, CE Hegeman, F Rodriguez-Trelles, H Fu, HK Dooner, J Lai, J Lai, J Ma, J Messing, J Vieira, JD Thompson, Jian-Hong Xu, Joachim Messing, K Ilic, KH Wolfe, M Morgante, M Nei, MC Timmermans, MD Gale, N Jiang, N Navaratnam, ON Danilevskaya, P Thuriaux, R Bock, R Bruggmann, R Ono, R Song, R Song, R Song, R Song, S Brunner, S Gupta, SD Mahan, SE Faivre-Nitschke, SF Altschul, SK Lal, SK Petersen-Mahrt, SO Freytag, T Doi, VV Kapitonov, WA Wilson, WM Nelson, Z Swigonova   +48 more
core   +3 more sources

The P2X7 Receptor and Its Relation to Neglected Tropical Diseases: Focusing on Chagas Disease

Journal of Tropical Medicine, Volume 2026, Issue 1, 2026.
Chagas disease, caused by Trypanosoma cruzi, is a neglected tropical disease (NTD) that can lead to severe cardiac complications, including chronic Chagas cardiomyopathy. While NTDs are caused by a variety of pathogens—such as protozoa, bacteria, viruses, and helminths, Chagas disease remains underexplored, particularly regarding host immune responses.
Caroline de Souza Ferreira Pereira, Robson Xavier Faria, Wei Wang   +2 more
wiley   +1 more source