Results 141 to 150 of about 193,772 (411)

Innovative Agents for Actinic Keratosis and Nanocarriers Enhancing Skin Penetration [PDF]

, 2010
Actinic keratosis and cutaneous squamous cell carcinoma are of increasing importance with aging and increased ultraviolet light exposure in Western societies. Efficient and well-tolerated therapy is still a matter of concern.
Höltje, H.-D., Höltje, M., Korting, Hans Christian, Schäfer-Korting, Monika   +3 more
core   +1 more source

Mitigating Cell Cycle Effects in Multi‐Omics Data: Solutions and Analytical Frameworks

Advanced Science, EarlyView.
The study highlights the cell‐cycle effects on multi‐omics analysis attributed to varying cell cycle compositions across cell types. To minimize the influence, we propose RTD correction in CNV calling with a high S‐phase ratio, and phase comparison in chromatin accessibility, DNA methylation, and transcriptomics.
Rui Nie, Caihong Zheng, Likun Ren, Yue Teng, Yaoyu Sun, Lifei Wang, Junya Li, Jun Cai   +7 more
wiley   +1 more source

The cumulative analgesic effect of repeated electroacupuncture is modulated by Adora3 in the SCDH of mice with neuropathic pain

Animal Models and Experimental Medicine, EarlyView.
Neuropathic pain management via repeated electroacupuncture. Abstract Background Existing remedial approaches for relieving neuropathic pain (NPP) are challenging and open the way for alternative therapeutic measures such as electroacupuncture (EA). The mechanism underlying the antinociceptive effects of repeated EA sessions, particularly concerning ...
Faisal Ayub Kiani, Hao Li, Panpan Guo, Qiulin Zhang, Mahmoud M. Abouelfetouh, Mingxing Ding, Yi Ding   +6 more
wiley   +1 more source

New Cerebroside and Nucleoside Derivatives from a Red Sea Strain of the Marine Cyanobacterium Moorea producens

Molecules, 2016
In the course of our ongoing efforts to identify marine-derived bioactive compounds, the marine cyanobacterium Moorea producens was investigated. The organic extract of the Red Sea cyanobacterium afforded one new cerebroside, mooreaside A (1), two new ...
Diaa T.A. Youssef, Sabrin R.M. Ibrahim, Lamiaa A. Shaala, Gamal A. Mohamed, Zainy M. Banjar   +4 more
doaj   +1 more source

RNA polymerase interactions and elongation rate [PDF]

arXiv, 2018
We show that non-steric molecular interactions between RNA polymerase (RNAP) motors that move simultaneously on the same DNA track determine strongly the kinetics of transcription elongation. With a focus on the role of collisions and cooperation, we introduce a stochastic model that allows for the exact analytical computation of the stationary ...
arxiv  

Applications of nucleoside-based molecular probes for the in vivo assessment of tumour biochemistry using positron emission tomography (PET)

Brazilian Archives of Biology and Technology, 2007
Positron emission tomography (PET) is a non-invasive nuclear imaging technique. In PET, radiolabelled molecules decay by positron emission. The gamma rays resulting from positron annihilation are detected in coincidence and mapped to produce three ...
Leonard I. Wiebe
doaj   +1 more source

Photoelektrochemische Eisen(III)‐Katalyse für C─H‐Fluoralkylierungen im synthetischen Spätstadium

Angewandte Chemie, EarlyView.
Eine effiziente elektrophotochemische C─H‐Fluoralkylierung von komplexen bioaktiven Verbindungen mit verfügbaren Fluoralkylcarbonsäuren unter Verwendung eines günstigen Eisen(III)‐Katalysators begleitet von der Wasserstoffentwicklungsreaktion wurde entwickelt.
Vladimir Motornov, Sven Trienes, Simonetta Resta, João C. A. Oliveira, Zhipeng Lin, Zhi Liu, Tristan von Münchow, Claudia Stückl, Lutz Ackermann   +8 more
wiley   +1 more source

Stannous Chloride: A Reagent for Removal of Dimethoxytrityl Group from 5'-Dimethoxytrityl Nucleosides [PDF]

Iranian Journal of Chemistry & Chemical Engineering, 1998
Detritylation of 5'-dimethoxytrityl nucleosides have been quantitatively achieved in minutes at room temperature under aprotic neutral conditions by using stannous chloride.
Ali Khalafi Nezhad, Reza Fareghi Alamdari   +1 more
doaj  

Emissive nucleosides as molecular rotors.

ChemPhysChem, 2011
Naturally occurring nucleosides, the building blocks of nucleic acids, are characterized by two distinct molecular elements: a rigid aromatic nucleobase and a more flexible (2’-deoxy)-d-ribose moiety.
Renatus W. Sinkeldam, Andrea Wheat, H. Boyaci, Y. Tor   +3 more
semanticscholar   +1 more source

Mechanochemical Strategies Applied to the Late‐Stage Modifications of Pharmaceutically Active Compounds

Angewandte Chemie International Edition, Accepted Article.
This review explores the potential of mechanochemistry in the late‐stage modification of active pharmaceutical ingredients (APIs), offering a comprehensive analysis of methods designed to transform structurally complex molecular scaffolds. By examining the scope, efficiency, and mechanistic aspects of these approaches, the review highlights protocols ...
Johanna Templ, Lars Borchardt
wiley   +1 more source