Results 141 to 150 of about 71,761 (247)

Emerging Therapeutic Strategies in Anti‐Aging Medicine: A Comprehensive Review

Medicine Bulletin, EarlyView.
ABSTRACT Aging is orchestrated by interconnected hallmarks such as genomic instability, mitochondrial dysfunction, cellular senescence, and disrupted intercellular communication, which collectively drive chronic disease progression. Recent advances have expanded therapeutic opportunities to include pharmacological agents, gene and epigenome editing ...
Yundong Peng, Rui Li, Huan Li, Jun Zhou, Xuanshi Liu, Guilherme Valente, Tatiana de Campos Melo, Sifan Chen, Lei Gu   +8 more
wiley   +1 more source

Nucleosides and Nucleotides. 110. [2,3]-Sigmatropic Rearrangement of the Allylic Selenides to Allylic Amines in Sugar Moiety of Pyrimidine Nucleosides: Synthesis of 3'-Amino-2',3'-dideoxy-2'-methylidenecytidine

, 1992
Akira Matsuda, Abdalla Alsyed A. Hassan
openalex   +1 more source

The ketogenic diet alters microbiome‐metabolome profiles to improve West syndrome therapy

Pediatric Investigation, EarlyView.
The ketogenic diet alleviates West syndrome by reshaping gut microbiota (increasing Bacteroides, Parabacteroides, and reducing Escherichia and Bifidobacterium), and modulating metabolites—including anticonvulsant lipids (e.g., capric acid), suppressed harmful lipids (e.g., 2‐methylbutyroylcarnitine), and amino acids and analogs (e.g., 3‐sulfinoalanine)—
Gan Xie, Qian Zhou, Jianxiang Liao, Yuejie Zheng, Wenjian Wang, Kunling Shen   +5 more
wiley   +1 more source

Direct and efficient synthesis of nucleosides through the ortho-(tert-butylethynyl)phenyl thioglycosides (BEPTs) protocol. [PDF]

Nat Commun
Liu H, Wang MY, Xie H, Qiu Y, Mao T, Shen X, Liu XX, Guo JJ, Tang MZ, Liao JX, Tu YH, Liu DY, Sun JS.   +12 more
europepmc   +1 more source

Proteome Analysis of Corynebacterium diphtheriae–Macrophage Interaction

PROTEOMICS, EarlyView.
ABSTRACT Contact of Corynebacterium diphtheriae with macrophages induces adaptations on both bacterial and cellular sides. The study presented here was aiming to shed light on the simultaneous intracellular adaptation of the bacteria and changes in the proteome of the phagocytes in response to the internalization of C. diphtheriae.
Luca Musella, Jens Möller, Christopher Lischer, Julio Vera‐Gonzalez, Jörg Hofmann, Lisa Ott, Andreas Burkovski   +6 more
wiley   +1 more source

Protocol for RNA modification analysis by UHPLC-QqQ MS. [PDF]

STAR Protoc
Tsai YL, Dai N, Corrêa IR.
europepmc   +1 more source

X-ray diffraction data for the 1.2 Angstrom Resolution Crystal Structure of Nucleoside Triphosphatase NudI from Klebsiella pneumoniae in Complex with HEPES (6DT3)

, 2018
G. Minasov, L. Shuvalova, S. Pshenychnyi, M. Endres, K.J.F. Satchell, A. Joachimiak, Center For Structural Genomics Of Infectious Diseases (CSGID)   +6 more
openalex   +1 more source

Role of the nucleoside-metabolizing enzymes on pain responses in zebrafish larvae

, 2022
Darlan Gusso, Melissa Talita Wiprich, Stefani Altenhofen, Carla Denise Bonan   +3 more
openalex   +2 more sources

Cationic‐Hydrophilic Di‐Block Copolymers: Surface‐Shielded Vectors for Gene Delivery

Journal of Polymer Science, Volume 63, Issue 6, Page 1419-1432, 15 March 2025.
This study develops synthetic polycationic di‐block carriers for nucleic acid (NA) delivery in gene therapy. Consisting of a cationic block and a hydrophilic block, these carriers efficiently form complexes with NAs and shield them with a protective bioinert layer, enhancing stability during circulation in the bloodstream while reducing undesirable ...
Eliška Hrdá, Ladislav Androvič, Marcela Filipová, Michal Pechar, Richard Laga   +4 more
wiley   +1 more source

A Dual Luminescent and Chromogenic Pt-NCN Complex for the Detection of GTP and CTP in Aqueous Media. [PDF]

Inorg Chem
Valdes-García J, Vonlanthen M, Cuétara-Guadarrama F, Garcia-Bassoco D, Valdés-Negrín HL, López-Pérez A, Rivera E, Hernández-Ortega S, Dorazco-González A.   +8 more
europepmc   +1 more source