Results 101 to 110 of about 156,001 (374)

Sequence Dependence of Transcription Factor-Mediated DNA Looping [PDF]

, 2012
DNA is subject to large deformations in a wide range of biological processes. Two key examples illustrate how such deformations influence the readout of the genetic information: the sequestering of eukaryotic genes by nucleosomes, and DNA looping in ...
Barry, Bellomy, Bellomy, Brenowitz, Butler, Chen, Chen, Cloutier, Cloutier, Drew, Du, Echols, Edelman, Finzi, Frank, Garcia, Geggier, Han, Hirsh, Hogan, Hsieh, Jacobson, Krämer, Lewis, Lowary, Luger, Luijsterburg, Martin Lindén, Matthews, Mehta, Milstein, Morgan, Müller, Newman, Normanno, Oehler, Olson, Peters, Plischke, Ptashne, Rippe, Rob Phillips, Rutkauskas, Saiz, Schafer, Schleif, Segall, Shimada, Stephanie Johnson, Swigon, Tolhuis, Towles, Vanzi, Villa, Watson, Whitson, Whitson, Widom, Wong, Xu, Yin, Zhan, Zhang   +62 more
core   +4 more sources

Structural basis for nucleosome remodeling by the INO80 complex

Nature, 2018
In the eukaryotic nucleus, DNA is packaged in the form of nucleosomes, each of which comprises about 147 base pairs of DNA wrapped around a histone protein octamer.
S. Eustermann, Kevin Schall, D. Kostrewa, K. Lakomek, M. Strauss, Manuela Moldt, K. Hopfner   +6 more
semanticscholar   +1 more source

Targeting WEE1 in ARID1A/TP53 Concurrent Mutant Colorectal Cancer by Exploiting R‐Loop Accumulation and DNA Repair Deficiencies

Advanced Science, EarlyView.
ARID1A, a SWI/SNF complex component, is frequently mutated in colorectal cancer (CRC). CRC with ARID1A/TP53 concurrent mutations shows marked sensitivity to WEE1 inhibition. ARID1A loss induces R‐loop‐mediated replication stress, impairs ATF3 transcription, and amplifies WEE1i‐induced DNA damage, suggesting a promising therapeutic vulnerability ...
Chi Zhang, Yanjing Zhu, Luoyan Ai, Jingyuan Wang, Shan Yu, Yichen Wang, Xiaojing Xu, Mengling Liu, Yiyi Yu, Mengxuan Zhu, Yutong Liu, Zhenghang Xu, Haojie Zhou, Huishan Li, Qihong Huang, Qing Liu, Ke Peng, Tianshu Liu   +17 more
wiley   +1 more source

Evaluation of plasma nucleosome concentrations in dogs with a variety of common cancers and in healthy dogs [PDF]

, 2022
Heather Wilson‐Robles, Thomas Bygott, Theresa K. Kelly, T. M. Miller, J. Philip Miller, Matthew Matsushita, Jason Terrell, Mhammed Bougoussa, Thomas Butera   +8 more
openalex   +1 more source

Adenylyl Cyclase 8 in Dorsal CA1 Neurons Prevents Depressive‐Like Behaviors by Maintaining Neuronal Excitability and Glutamatergic Neurotransmission Through TIP39‐PTH2R Signaling

Advanced Science, EarlyView.
Depression, a prevalent neuropsychiatric disorder with unclear pathogenesis, involves dysfunctional adenylyl cyclase 8 (Adcy8) as a key risk factor. Chronic stress selectively reduces Adcy8 expression in the dorsal CA1 (dCA1) neurons. Depletion of Adcy8 in dCA1 excitatory neurons induces depressive‐like behaviors by impairing neuronal excitability and ...
Zi‐Jie Liu, Jia‐Rui Bi, Zong‐Yan Yu, Meng Tian, Zhi‐Yue Chen, Ran Wei, Miao‐Miao Wang, Hai‐Wei Zha, Yu‐Qing Zhang, Hong‐Jing Wang, Bang‐You Qiang, Shuang‐Shuang Sun, Xiao‐Juan Zhu, Wen‐Bing Chen, Dong Sun   +14 more
wiley   +1 more source

Defining transcription factor nucleosome binding with Pioneer-seq.

PLoS Genetics
Gene expression requires the targeting of transcription factors (TFs) to regulatory sequences often occluded within nucleosomes. To comprehensively examine TF nucleosome binding, we developed Pioneer-Seq.
Maria Tsompana, Patrick D Wilson, Vijaya Murugaiyan, Christopher R Handelmann, Michael J Buck   +4 more
doaj   +1 more source

NAP1-assisted nucleosome assembly on DNA measured in real time by single-molecule magnetic tweezers.

PLoS ONE, 2012
While many proteins are involved in the assembly and (re)positioning of nucleosomes, the dynamics of protein-assisted nucleosome formation are not well understood.
Rifka Vlijm, Jeremy S J Smitshuijzen, Alexandra Lusser, Cees Dekker   +3 more
doaj   +1 more source

An organometallic compound which exhibits a DNA topology-dependent one-stranded intercalation mode [PDF]

, 2016
Understanding how small molecules interact with DNA is essential since it underlies a multitude of pathological conditions and therapeutic interventions.
Adhireksan, Aird, Baruah, Brunk, Chen, Chua, Chua, Davey, Liu, Novakova, Ong, Rescifina, Spingler, Wu, Wu, Wu, Zeglis   +16 more
core   +2 more sources

A Self‐Organized Liquid Reaction Container for Cellular Memory

Advanced Science, EarlyView.
How cells restore epigenetic information lost during replication is not known. This work proposes a mechanism based on the formation of biomolecular condensates. These condensates are induced by the chromosome itself and serve as reaction vessels for reconstructing missing epigenetic markers.
Sukanta Mukherjee, Enrico Skoruppa, Holger Merlitz, Jens‐Uwe Sommer, Helmut Schiessel   +4 more
wiley   +1 more source

Distinct modes of regulation by chromatin encoded through nucleosome positioning signals.

PLoS Computational Biology, 2008
The detailed positions of nucleosomes profoundly impact gene regulation and are partly encoded by the genomic DNA sequence. However, less is known about the functional consequences of this encoding.
Yair Field, Noam Kaplan, Yvonne Fondufe-Mittendorf, Irene K Moore, Eilon Sharon, Yaniv Lubling, Jonathan Widom, Eran Segal   +7 more
doaj   +1 more source