Results 101 to 110 of about 64,059 (299)

Affinity, stoichiometry and cooperativity of heterochromatin protein 1 (HP1) binding to nucleosomal arrays [PDF]

, 2014
Heterochromatin protein 1 (HP1) participates in establishing and maintaining heterochromatin via its histone modification dependent chromatin interactions. In recent papers HP1 binding to nucleosomal arrays was measured in vitro and interpreted in terms of nearest-neighbor cooperative binding. This mode of chromatin interactions could lead to spreading
arxiv   +1 more source

Is Enhancer Function Driven by Protein–Protein Interactions? From Bacteria to Leukemia

BioEssays, EarlyView.
Enhancers are key regulatory elements that are conceptually conserved from bacteria to humans. Enhancer dysregulation is common in cancers, including leukemia. We argue that highly specific protein–protein interactions, including transcription factors, mediate enhancer‐promoter proximity to allow enhancer‐bound factors to directly act on RNA polymerase
Nicholas T. Crump, Thomas A. Milne
wiley   +1 more source

Review on the o‐Aminoaniline Moiety in Peptide and Protein Chemistry

ChemBioChem, EarlyView.
The ability to prepare functional peptides and protein molecules is essential to understand fundamental biological processes and develop novel therapeutics for numerous diseases. In this review, Hong et al. document the development of o‐aminoaniline derivatives for chemical protein synthesis, peptide C‐terminus diversification, and cyclic peptide ...
Ziyong Z. Hong
wiley   +1 more source

Nucleosome positioning and energetics: Recent advances in genomic and computational studies [PDF]

Advances in Protein Chemistry and Structural Biology, Volume 79 (2010) Pages 1-57, 2009
Chromatin is a complex of DNA, RNA and proteins whose primary function is to package genomic DNA into the tight confines of a cell nucleus. A fundamental repeating unit of chromatin is the nucleosome, an octamer of histone proteins around which 147 base pairs of DNA are wound in almost two turns of a left-handed superhelix.
arxiv  

Advancements in the Application of the Intersection of Medicine and Engineering in Cancer Research

Cancer Nexus, EarlyView.
ABSTRACT Cancer research predominantly centers on diagnosis, treatment, and elucidation of underlying mechanisms. Nevertheless, the intricate nature of tumor genesis and development has rendered early diagnostic and therapeutic outcomes less than optimal, making tumor conquest a formidable challenge.
Haitao Chen, Guanmeng Zhang, Yuping Qian, Yang Peng, Xiaoli Li, Jiawen Wang, Jinlan Wang, Yuxiang Hu, Han Xiao, Qinqiu Zhong, Xin Li, Yumeng Xie, Yukun Chen, Lijun Zhao, Qiqi Jing, Xiaofeng Shan, Yuguang Wang   +16 more
wiley   +1 more source

Advances in Isotope Labeling for Solution Nucleic Acid NMR Spectroscopy

ChemPlusChem, Accepted Article.
The availability of nucleic acid structural biology methods still lags behind that of proteins, as evidenced by the significantly smaller number of structures deposited in the PDB. The highly skewed ratio of nucleic acid structures, relative to their protein counterparts (~1:50), is inverted with respect to the cellular output of RNA and proteins in ...
Stefan Hilber, Solomon Kojo Attionu, Theodore Kwaku Dayie, Christoph Kreutz   +3 more
wiley   +1 more source

GATAD2B‐related developmental and epileptic encephalopathy (DEE): Extending the epilepsy phenotype and a literature appraisal

Epilepsia Open, EarlyView.
Abstract Heterozygous pathogenic variants in GATAD2B gene have been related to the GATAD2B‐associated neurodevelopmental disorders (GAND) characterized by neurodevelopmental delay with predominant language impairment, infantile hypotonia, macrocephaly, ophthalmological abnormalities, and dysmorphic facial features with nonspecific findings on brain ...
Giovanna Scorrano, Giulia Barcia, Jérôme Champ, Thomas Courtin, Nathalie Boddaert, Anna Kaminska, Nicole Chemaly, Rima Nabbout   +7 more
wiley   +1 more source

Creating a bacterium that forms eukaryotic nucleosome core particles

Nature Communications
The nucleosome is one of the hallmarks of eukaryotes, a dynamic platform that supports many critical functions in eukaryotic cells. Here, we engineer the in vivo assembly of the nucleosome core in the model bacterium Escherichia coli.
Xinyun Jing, Niubing Zhang, Xiaojuan Zhou, Ping Chen, Jie Gong, Kaixiang Zhang, Xueting Wu, Wenjuan Cai, Bang-Ce Ye, Pei Hao, Guo-ping Zhao, Sheng Yang, Xuan Li   +12 more
doaj   +1 more source

Transcriptional interaction-assisted identification of dynamic nucleosome positioning

BMC Bioinformatics, 2009
Background Nucleosomes regulate DNA accessibility and therefore play a central role in transcription control. Computational methods have been developed to predict static nucleosome positions from DNA sequences, but nucleosomes are dynamic in vivo ...
Deng Yangyang, Feng Jihua, Xiang Qian, Dai Xianhua, Dai Zhiming, Wang Jiang, He Caisheng   +6 more
doaj   +1 more source

Chromatin: The nucleosome unwrapped [PDF]

Current Biology, 1997
The structure of the nucleosome core particle has been determined by X-ray crystallography at 2.8 A resolution. The structure has several significant surprises, and provides important new insights into the structure and function of chromatin.
openaire   +3 more sources