Results 111 to 120 of about 156,001 (374)

Complex exon-intron marking by histone modifications is not determined solely by nucleosome distribution [PDF]

, 2010
It has recently been shown that nucleosome distribution, histone modifications and RNA polymerase II (Pol II) occupancy show preferential association with exons (“exon-intron marking”), linking chromatin structure and function to co-transcriptional ...
A Barski, A Tyagi, AJ Bannister, Alexander W. Bruce, Anton Wutz, AW Bruce, AW Bruce, B Langmead, B Li, BB Lozzio, BE Bernstein, Christoph M. Koch, CK Lee, CM Koch, Cordelia Langford, David Vetrie, E Allemand, E Batsche, E Birney, EC Forsberg, G Felsenfeld, G Hon, G Nogues, H Tilgner, Ian Dunham, IE Schor, Jackie Bye, JW Larrick, Keith James, Kelly Chiang, KJ Howe, M Allo, M de la Mata, M Yonaha, MC Keogh, MJ Carrozza, N Spies, NA Watkins, ND Heintzman, ND Robson-Dixon, Nicholas A. Watkins, Nicola S. Foad, Nicolas Bonhoure, NJ Park, P Dhami, P Kolasinska-Zwierz, Pawandeep Dhami, Peter Ellis, Peter Saffrey, PG Giresi, PL Nagy, R Andersson, R Landick, RF Luco, RJ Sims, RJ Sims, RK Auerbach, Robert M. Andrews, S Cuddapah, S Nahkuri, S Schwartz, S Schwartz, Shane C. Dillon, T Jenuwein, Willem H. Ouwehand, Y Mito, Z Wang   +66 more
core   +5 more sources

Structure of the RSC complex bound to the nucleosome

Science, 2019
The architecture of the RSC complex RSC is a Snf2-family chromatin remodeler complex that controls the promoter architecture of most of the genes in yeast. Using single-particle cryo–electron microscopy, Ye et al. determined the structure of RSC bound to
Y. Ye, Hao Wu, Kangjing Chen, Cedric R. Clapier, N. Verma, Wenhao Zhang, Haiteng Deng, B. Cairns, N. Gao, Zhucheng Chen   +9 more
semanticscholar   +1 more source

Mediator?Nucleosome Interaction [PDF]

Molecular Cell, 2000
Mediator, a multiprotein complex involved in the regulation of RNA polymerase II transcription, binds to nucleosomes and acetylates histones. Three lines of evidence identify the Nut1 subunit of Mediator as responsible for the histone acetyltransferase (HAT) activity. An "in-gel" HAT assay reveals a single band of the appropriate size.
Y, Lorch, J, Beve, C M, Gustafsson, L C, Myers, R D, Kornberg   +4 more
openaire   +2 more sources

Nap1L4a Cooperates with Scl/Klf1 to Recruit H2A.Z in Mediating Interactions Among Cis‐Regulatory Elements and Transcription Required for Primitive Erythropoiesis in Zebrafish

Advanced Science, EarlyView.
Nap1l4a is required in erythropoiesis and hypoxia responses via physical interaction with Klf1 and Scl to recruit the histone variant H2A.Z. This facilitates its associated cis‐regulatory element (CRE) remodeling and the consequent chromatin assembly, and activates the transcription of erythroid lineage‐specific genes.
JiaHao Shi, FuMing Lai, Zheng Shen, XiaoYan Zhang, HanFei Wang, WenYe Liu, YunLong Wang, KuanYu Li, GuoLiang Li, YaPing Fang, Jing‐Xia Liu   +10 more
wiley   +1 more source

Nucleosome-Chd1 structure and implications for chromatin remodelling

Nature, 2017
Chromatin-remodelling factors change nucleosome positioning and facilitate DNA transcription, replication, and repair. The conserved remodelling factor chromodomain-helicase-DNA binding protein 1(Chd1) can shift nucleosomes and induce regular nucleosome ...
L. Farnung, S. Vos, C. Wigge, P. Cramer
semanticscholar   +1 more source

Cancer‐Like Fragmentomic Characteristics of Somatic Variants in Cell‐Free DNA

Advanced Science, EarlyView.
We report that in non‐cancerous subjects, cell‐free (cfDNA) molecules harboring somatic variants exhibit cancer‐like fragmentomic characteristics associated with clonal hematopoiesis. Importantly, these somatic variant‐associated fragmentomic aberrations are more pronounced in cancer patients. Leveraging such somatic variant‐associated signals in cfDNA,
Zhenyu Zhang, Yunyun An, Mengqi Yang, Yuqi Pan, Xiaoyi Liu, Fanglei Gong, Huizhen Lin, Bianbian Tang, Yunxia Bai, Xin Zhao, Yu Zhao, Changzheng Du, Kun Sun   +12 more
wiley   +1 more source

Insights into distinct regulatory modes of nucleosome positioning

BMC Genomics, 2009
Background The nucleosome is the fundamental unit of eukaryotic genomes. Experimental evidence suggests that the genomic DNA sequence and a variety of protein factors contribute to nucleosome positioning in vivo.
Feng Jihua, Xiang Qian, Dai Xianhua, Dai Zhiming, Deng Yangyang, Wang Jiang   +5 more
doaj   +1 more source

A global function for transcription factors in assisting RNA polymerase II termination. [PDF]

, 2017
The role of transcription factors (TFs) on nucleosome positioning, RNA polymerase recruitment, and transcription initiation has been extensively characterized.
Chanfreau, Guillaume F, Roy, Kevin
core   +1 more source

TP53BP2 Promotes Placental Autophagy and Preeclampsia via G9a and DNMT1 Cooperatively Modulating E2F1

Advanced Science, EarlyView.
G9a, and DNA Methyltransferase1 (DNMT1) cooperatively modulates E2F1 on the promoter of tumor suppressor p53‐binding protein 2 (TP53BP2) increased autophagy in preeclampsia. TP53BP2 promotes autophagy in trophoblasts through DNA methylation and H3K9me2‐mediated transcriptional regulation.
Nan Jiang, Shaoju Jin, Shaoying Wen, Wen Zeng, Chen Wang, Jingyu Wang, Qingyun Song, Guizhong Li, Pengzhi Yin, Yuhui Liao, Yuee Chai, Huiping Zhang, Shengchao Ma   +12 more
wiley   +1 more source

Structural features based genome-wide characterization and prediction of nucleosome organization

BMC Bioinformatics, 2012
Background Nucleosome distribution along chromatin dictates genomic DNA accessibility and thus profoundly influences gene expression. However, the underlying mechanism of nucleosome formation remains elusive.
Gan Yanglan, Guan Jihong, Zhou Shuigeng, Zhang Weixiong   +3 more
doaj   +1 more source