Results 111 to 120 of about 141,257 (371)

Structure of the RSC complex bound to the nucleosome

Science, 2019
The architecture of the RSC complex RSC is a Snf2-family chromatin remodeler complex that controls the promoter architecture of most of the genes in yeast. Using single-particle cryo–electron microscopy, Ye et al. determined the structure of RSC bound to
Y. Ye, Hao Wu, Kangjing Chen, Cedric R. Clapier, N. Verma, Wenhao Zhang, Haiteng Deng, B. Cairns, N. Gao, Zhucheng Chen   +9 more
semanticscholar   +1 more source

A Split Personality for Nucleosomes [PDF]

Cell, 2014
A high-resolution look at where histones touch DNA reveals a surprisingly intricate, dynamic, and modular nucleosome. Three advances in the study by Rhee et al. include unexpected interactions between the H3 tail and linker DNA, new evidence for existence of subnucleosomal particles, and asymmetric patterns of histone modification within a single ...
Jason D. Lieb, Daniel J. McKay
openaire   +3 more sources

Genome-wide organization of eukaryotic pre-initiation complex is influenced by nonconsensus protein-DNA binding [PDF]

, 2013
Genome-wide binding preferences of the key components of eukaryotic pre-initiation complex (PIC) have been recently measured with high resolution in Saccharomyces cerevisiae by Rhee and Pugh (Nature (2012) 483:295-301).
Afek, Ariel, Lukatsky, David B.
core   +2 more sources

Differences in Dynamics of Specific Antinuclear Antibodies and Their Susceptibility to B Cell–Targeting Treatment in Patients With Systemic Lupus Erythematosus

Arthritis &Rheumatology, EarlyView.
Objective The presence of antinuclear antibodies (ANAs) is characteristic for systemic lupus erythematosus (SLE). Antibody dynamics over time are thought to reflect the cellular source of ANAs and their therapeutic targetability. Anti–double‐stranded DNA (anti‐dsDNA) is the most prevalent and well‐studied of all ANAs, and fluctuations in anti‐dsDNA ...
Hugo J. van Dooren, Mieke van Schaik, Annemarie L. Dorjée, Eline J. Arends, Meggan Mackay, Laura Cooney, David A. Fox, David Wofsy, Dawn Smilek, Cynthia Aranow, Maria Dall'Era, Tom W. J. Huizinga, Cees van Kooten, René E. M. Toes, Betty Diamond, Y. K. Onno Teng, Jolien Suurmond   +16 more
wiley   +1 more source

Diversity of eukaryotic DNA replication origins revealed by genome-wide analysis of chromatin structure. [PDF]

PLoS Genetics, 2010
Eukaryotic DNA replication origins differ both in their efficiency and in the characteristic time during S phase when they become active. The biological basis for these differences remains unknown, but they could be a consequence of chromatin structure ...
Nicolas M Berbenetz, Corey Nislow, Grant W Brown   +2 more
doaj   +1 more source

Nucleosome-Chd1 structure and implications for chromatin remodelling

Nature, 2017
Chromatin-remodelling factors change nucleosome positioning and facilitate DNA transcription, replication, and repair. The conserved remodelling factor chromodomain-helicase-DNA binding protein 1(Chd1) can shift nucleosomes and induce regular nucleosome ...
L. Farnung, S. Vos, C. Wigge, P. Cramer
semanticscholar   +1 more source

Crosstalk between chromatin structure, cohesin activity and transcription [PDF]

, 2019
Background: A complex interplay between chromatin and topological machineries is critical for genome architec‑ ture and function. However, little is known about these reciprocal interactions, even for cohesin, despite its multiple roles in DNA metabolism.
Andújar, Eloísa, Barrientos Moreno, Marta, Cabello Lobato, María José, Gómez Marín, Elena, Maya Miles, Douglas, Morillo Huesca, Macarena, Murillo Pineda, Marina, Prado, Félix, Pérez Alegre, Mónica   +8 more
core   +1 more source

Autoantibody response towards chromatin in patients with juvenile idiopathic arthritis

Arthritis &Rheumatology, Accepted Article.
Objective Juvenile idiopathic arthritis (JIA) patients frequently exhibit antinuclear antibodies (ANAs), but the specific antigen target recognized by them and the presence of additional autoantibody specificities in JIA patients remains elusive. Methods Plasma samples from 110 untreated patients with active JIA, as well as from 14 children with ...
Viola Pitkänen, Terhi Remes‐Pakarinen, Paula Vähäsalo, Milja Möttönen, Minna‐Maija Grönlund, Miika Arvonen, Mikael Knip, Riitta Veijola, Jorma Toppari, Jorma Ilonen, Johanna Lempainen, Anna‐Mari Schroderus, Liisa Kröger, Tuure Kinnunen   +13 more
wiley   +1 more source

NAP1-assisted nucleosome assembly on DNA measured in real time by single-molecule magnetic tweezers.

PLoS ONE, 2012
While many proteins are involved in the assembly and (re)positioning of nucleosomes, the dynamics of protein-assisted nucleosome formation are not well understood.
Rifka Vlijm, Jeremy S J Smitshuijzen, Alexandra Lusser, Cees Dekker   +3 more
doaj   +1 more source

High-resolution and high-accuracy topographic and transcriptional maps of the nucleosome barrier. [PDF]

, 2019
Nucleosomes represent mechanical and energetic barriers that RNA Polymerase II (Pol II) must overcome during transcription. A high-resolution description of the barrier topography, its modulation by epigenetic modifications, and their effects on Pol II ...
Brown, Aidan I, Bustamante, Carlos, Chen, Zhijie, Díaz-Celis, César, Gabizon, Ronen, Kaplan, Craig D, Koslover, Elena F, Lee, Antony, Song, Aixin, Yao, Tingting   +9 more
core   +2 more sources