Results 131 to 140 of about 64,059 (299)

Divalent Metal- and High Mobility Group N Protein-Dependent Nucleosome Stability and Conformation

open access: yesJournal of Nucleic Acids, 2010
High mobility group N proteins (HMGNs) bind specifically to the nucleosome core and act as chromatin unfolding and activating factors. Using an all-Xenopus system, we found that HMGN1 and HMGN2 binding to nucleosomes results in distinct ion-dependent ...
Michelle S. Ong   +2 more
doaj   +1 more source

The GntR/VanR transcription regulator AlkR represses AlkB2 monooxygenase expression and regulates n‐alkane degradation in Pseudomonas aeruginosa SJTD‐1

open access: yesmLife, EarlyView.
Abstract Transmembrane alkane monooxygenase (AlkB)‐type monooxygenases, especially AlkB2 monooxygenases, are crucial for aerobic degradation of the medium‐to‐long‐chain n‐alkanes in hydrocarbon‐utilizing microorganisms. In this study, we identified a GntR/VanR transcription regulator AlkR of Pseudomonas aeruginosa SJTD‐1 involved in the negative ...
Wanli Peng   +11 more
wiley   +1 more source

Gene splice sites correlate with nucleosome positions [PDF]

open access: yesarXiv, 2004
Gene sequences in the vicinity of splice sites are found to possess dinucleotide periodicities, especially RR and YY, with the period close to the pitch of nucleosome DNA. This confirms previously reported finding about preferential positioning of splice junctions within the nucleosomes.
arxiv  

Brd9 antagonism induces beige adipocytes in white adipose tissues and protects against diet‐induced obesity

open access: yesObesity, EarlyView.
Abstract Objective Thermogenic beige adipocytes emerge in white adipose tissue (WAT) under certain physiological and pathological conditions, leading to increased energy expenditure, insulin sensitivity, and glucose tolerance. The induction of beige adipocyte formation represents a promising therapeutic approach for obesity and associated chronic ...
Yang Liu   +4 more
wiley   +1 more source

Characteristic H3 N-tail dynamics in the nucleosome core particle, nucleosome, and chromatosome

open access: yesiScience, 2022
Summary: The nucleosome core particle (NCP) comprises a histone octamer, wrapped around by ∼146-bp DNA, while the nucleosome additionally contains linker DNA.
Ayako Furukawa   +7 more
doaj  

Key Regulators of Parasite Biology Viewed Through a Post‐Translational Modification Repertoire

open access: yesPROTEOMICS, EarlyView.
ABSTRACT Parasites are the leading causes of morbidity and mortality in both humans and animals, imposing substantial socioeconomic burdens worldwide. Controlling parasitic diseases has become one of the key issues in achieving “One Health”. Most parasites have sophisticated life cycles exhibiting progressive developmental stages, morphologies, and ...
Naiwen Zhang, Ning Jiang, Qijun Chen
wiley   +1 more source

Double the Double: Revisiting BCL11B's Multimerization

open access: yesProteins: Structure, Function, and Bioinformatics, EarlyView.
ABSTRACT The transcription factor B Cell Lymphoma/Leukemia 11B (BCL11B) exerts a bi‐directional function in cancer, with its role as an emerging therapeutic target in cancer treatment being particularly intriguing. BCL11B knockouts in cultured T cells revealed the acquisition of properties characteristic of natural killer cells, hinting at its ...
Anne Susemihl   +5 more
wiley   +1 more source

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