Results 131 to 140 of about 141,257 (371)
Structural features based genome-wide characterization and prediction of nucleosome organization
BMC Bioinformatics, 2012 Background Nucleosome distribution along chromatin dictates genomic DNA accessibility and thus profoundly influences gene expression. However, the underlying mechanism of nucleosome formation remains elusive.
Gan Yanglan +3 more
doaj +1 more source
The DNA-encoded nucleosome organization of a eukaryotic genome
Nature, 2009 Nucleosome organization is critical for gene regulation. In living cells this organization is determined by multiple factors, including the action of chromatin remodellers, competition with site-specific DNA-binding proteins, and the DNA sequence ...
Noam Kaplan +10 more
semanticscholar +1 more source
TRF1 and TRF2 binding to telomeres is modulated by nucleosomal organization [PDF]
, 2015 The ends of eukaryotic chromosomes need to be protected from the activation of a DNA damage response that leads the cell to replicative senescence or apoptosis.
Alicata, Claudia +8 more
core +2 more sources
Head &Neck, EarlyView.ABSTRACT Background The incidence of Nasopharyngeal carcinoma (NPC) is rising in recent years, especially in some non‐developed parts of the world. Hence, cost‐efficient means for sensitive detection of NPC are vital. Methods We recruited 646 participants, including healthy individuals, patients with benign nasopharyngeal diseases, and NPC patients for
Song Zhang +10 more
wiley +1 more source
Cell cycle-specified fluctuation of nucleosome occupancy at gene promoters.
PLoS Genetics, 2006 The packaging of DNA into nucleosomes influences the accessibility of underlying regulatory information. Nucleosome occupancy and positioning are best characterized in the budding yeast Saccharomyces cerevisiae, albeit in asynchronous cell populations or
Gregory J Hogan +2 more
doaj +1 more source
bioRxiv, 2017 Gaining insights into the regulatory mechanisms that underlie the transcriptional variation observed between individual cells necessitates the development of methods that measure chromatin organization in single cells. Here I adapted Nucleosome Occupancy
Sebastian Pott
semanticscholar +1 more source
A hitchhiker's guide to single‐cell epigenomics: Methods and applications for cancer research
International Journal of Cancer, EarlyView.Abstract Genetic mutations are well known to influence tumorigenesis, tumor progression, treatment response and relapse, but the role of epigenetic variation in cancer progression is still largely unexplored. The lack of epigenetic understanding in cancer evolution is in part due to the limited availability of methods to examine such a heterogeneous ...
Marta Moreno‐Gonzalez +2 more
wiley +1 more source
Polymer reptation and nucleosome repositioning
, 2001 We consider how beads can diffuse along a chain that wraps them, without becoming displaced from the chain; our proposed mechanism is analogous to the reptation of "stored length" in more familiar situations of polymer dynamics. The problem arises in the
D. Keller +18 more
core +2 more sources
Epigenomics‐guided precision oncology: Chromatin variants in prostate tumor evolution
International Journal of Cancer, EarlyView.Abstract Prostate cancer is a common malignancy that in 5%–30% leads to treatment‐resistant and highly aggressive disease. Metastasis‐potential and treatment‐resistance is thought to rely on increased plasticity of the cancer cells—a mechanism whereby cancer cells alter their identity to adapt to changing environments or therapeutic pressures to create
Kira Furlano +6 more
wiley +1 more source
Structural basis for COMPASS recognition of an H2B-ubiquitinated nucleosome
bioRxiv, 2019 Methylation of histone H3K4 is a hallmark of actively transcribed genes that depends on mono-ubiquitination of histone H2B (H2B-Ub). H3K4 methylation in yeast is catalyzed by Set1, the methyltransferase subunit of COMPASS.
E. Worden, Xiangbin Zhang, C. Wolberger
semanticscholar +1 more source