Results 131 to 140 of about 70,917 (227)

Iron, arginine, and redox metabolism in peripheral blood mononuclear cells distinguishes sickle cell disease and pulmonary hypertension

HemaSphere, Volume 10, Issue 3, March 2026.
Abstract Pulmonary hypertension (PH) is a severe vascular complication of sickle cell disease (SCD); yet, not all patients with SCD develop PH, and PH also arises independently. This duality underscores the need to understand their intersecting biology.
Francesca I. Cendali, Christina Lisk, Amy Argabright, Monika Dzieciatkowska, Nishant K. Rana, Delaney Swindle, Daniel Stephenson, Julie McAfee, Natalie Westover, Melissa Lucero, Aneta Gandjeva, Kurt Stenmark, Rubin Tuder, Brian B. Graham, Tim Lahm, Vijaya Karoor, Gemlyn George, Kathryn Hassel, Rachelle Nuss, Pavel Davizon‐Castillio, Paul W. Buehler, Angelo D'Alessandro, David C. Irwin   +22 more
wiley   +1 more source

Recognition and remodelling of nucleosomes and hexasomes by the human INO80 complex. [PDF]

Nucleic Acids Res
Aggarwal P, Sharma M, Woike S, Kunert F, Brem A, Moldt M, Hopfner KP.   +6 more
europepmc   +1 more source

Novel therapeutic strategy targeting STMN1 using chlorambucil‐conjugated pyrrole–imidazole polyamide in small cell lung cancer

International Journal of Cancer, Volume 158, Issue 5, Page 1336-1347, 1 March 2026.
What's New? Small cell lung cancer (SCLC) is aggressive and difficult to treat but exhibits high levels of stathmin 1 (STMN1), a candidate therapeutic target. In this study, the authors synthesized a chlorambucil (Chb)‐conjugated pyrrole–imidazole polyamide (PIP) compound targeting the STMN1 promoter and DNA sequences and evaluated its efficacy in ...
Ryohei Yoshikawa, Takayoshi Watanabe, Yoichi Ohtaki, Toshikazu Bando, Hiroshi Sugiyama, Takuya Araki, Hideaki Yashima, Bilguun Erkhem‐Ochir, Haruka Okami, Gendensuren Dorjkhorloo, Ikuma Shioi, Toshiteru Nagashima, Natsuko Kawatani, Tomohiro Yazawa, Eiji Narusawa, Takayuki Kosaka, Osamu Kawashima, Mitsuhiro Kamiyoshihara, John D. Minna, Luc Girard, Ken Shirabe, Hiroki Nagase, Kimihiro Shimizu, Takehiko Yokobori   +23 more
wiley   +1 more source

Structural basis of transcription-coupled H3K36 trimethylation by Set2 in coordination with FACT. [PDF]

Sci Adv
Kujirai T, Ehara H, Ito T, Henmi M, Oya E, Kobayashi T, Sekine SI, Kurumizaka H.   +7 more
europepmc   +1 more source

PIEZO1 Channels Modulate the Small Extracellular Vesicle Release in C2C12 Cells

Journal of Cellular Physiology, Volume 241, Issue 3, March 2026.
ABSTRACT PIEZO1 are mechanically‐activated ion channels expressed in many cell types. Their pharmacological activation by the selective agonist Yoda1 has been reported to favor skeletal muscle regeneration by controlling the fate of myogenic precursors cells, but the underlying mechanisms remain largely unknown.
Bernareggi Annalisa, Zhang Wen Ru, Sanchez‐Sanchez Laura, Norbedo Alessia, Fracassi Anna, Lucafò Marianna, Sciancalepore Marina, Alberto Griffoni, Russell K. William, Taglialatela Giulio, Lorenzon Paola, Limon Agenor   +11 more
wiley   +1 more source

Conformations of Linker Histone H1 Bound to Nucleosome Arrays. [PDF]

J Mol Biol
Yuan B, Das SK, Wang W, Camacho G, Kumar A, Hayes JJ, Lee TH.   +6 more
europepmc   +1 more source

Clinical Application of Peripheral Blood Biomarkers for Solid Tumors

MedComm, Volume 7, Issue 3, March 2026.
Peripheral blood biomarkers provide a minimally invasive, dynamic, and potentially more accurate means to obtain a comprehensive tumor profile. Technologies for detecting them are advancing, and with the help of artificial intelligence, they are being used more and more often for cancer diagnosis, prognostic assessment, and therapeutic monitoring ...
Xinru Tu, Mengyan Tu, Junfen Xu
wiley   +1 more source

An experimentally-informed polymer model reveals high resolution organization of genomic loci. [PDF]

Nat Commun
Mittal R, Heermann DW, Bhattacherjee A.
europepmc   +1 more source

Chromatin Accessibility in Cancer: Biological Functions, Mechanisms, Therapeutic Potential, and Future Directions

MedComm, Volume 7, Issue 3, March 2026.
Cancer remains the leading cause of mortality worldwide, and drug resistance further underscores the urgent need for innovative therapeutic strategies. Chromatin, a stable yet highly dynamic nucleoprotein complex, serves as the primary carrier of genetic material in eukaryotic cells.
Wentao Xia, Min Jiang, Yefei Huang, Kun Ding, Yansu Chen   +4 more
wiley   +1 more source

HDGS-Net: nucleosome occupancy prediction based on a hybrid dilated gated separable convolutional neural network. [PDF]

BMC Genomics
Shi F, Wang M, Teng Z, Cai L, Liu G, Xing Y, Cui X, Liu G, Yang Z, Meng H.   +9 more
europepmc   +1 more source