Results 141 to 150 of about 64,059 (299)

Association of DNA Polymerase with Nucleosomes from Mammalian Cell Chromatin [PDF]

open access: bronze, 1978
Ernst‐Jürgen Schlaeger   +3 more
openalex   +1 more source

Phosphorylation of an RNA‐Binding Protein Rck/Me31b by Hippo Is Essential for Adipose Tissue Aging

open access: yesAging Cell, EarlyView.
Evolutionary conserved Hippo/Mst1 signaling non‐canonically regulates the stability of mRNAs through directly phosphorylating a subset of RNA binding proteins to stabilize lipolytic mRNAs. Hpo pathway contributes to the regulation of Drosophila lifespan by modulating the expression and activity of Me31b/RCK, which subsequently affects mRNA levels of ...
Eunbyul Yeom   +26 more
wiley   +1 more source

HN1 Functions in Protein Synthesis Regulation via mTOR‐RPS6 Axis and Maintains Nucleolar Integrity

open access: yesCell Proliferation, EarlyView.
HN1 is required for nucleolar homeostasis which is the site of ribosome biogenesis and protein synthesis when its mRNA is knocked down by shRNA, it depletes in cytoplasm and the protein synthesis is downregulated in comparison to controls. Thus, the proliferating cells requiring vast number of nucleosomes, are arrested at S onset.
Gülseren Özduman   +4 more
wiley   +1 more source

Nucleosomes at the Dawn of Eukaryotes

open access: yesGenome Biology and Evolution
Abstract Genome regulation in eukaryotes revolves around the nucleosome, the fundamental building block of eukaryotic chromatin. Its constituent parts, the four core histones (H3, H4, H2A, H2B), are universal to eukaryotes. Yet despite its exceptional conservation and central role in orchestrating transcription, repair, and other DNA ...
Hocher, A, Warnecke, T
openaire   +2 more sources

Membraneless Organelles and Phase Separation in Tumours: Mechanisms and Prospects

open access: yesCell Proliferation, EarlyView.
The Salient and Novel Findings: This article summarises the latest research advancements in phase separation within tumours, with a particular focus on the role and molecular mechanisms of liquid–liquid phase separation (LLPS) in tumour progression.
Hao Yang   +3 more
wiley   +1 more source

Nucleosome core histone complex isolated gently and rapidly in 2 M NaCl is octameric.

open access: green, 1979
Muruthi Philip   +3 more
openalex   +1 more source

Pathogenic variants in chromatin‐related genes: Linking immune dysregulation to neuroregression and acute neuropsychiatric disorders

open access: yesDevelopmental Medicine &Child Neurology, EarlyView.
Chromatin machinery influences how DNA is ‘wrapped’ around histones in the nucleosome of immune and brain cells. Plain language summary: https://onlinelibrary.wiley.com/doi/10.1111/dmcn.16299 Abstract We report eight children with de novo pathogenic DNA variants in chromatin‐related genes: MORC2, CHD7, KANSL1, KMT2D, ZMYND11, HIST1HIE, EP300, and KMT2B.
Russell C. Dale   +14 more
wiley   +1 more source

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