Results 141 to 150 of about 156,001 (374)
Non‐Histone Lactylation: A New Frontier in Cerebral Ischemia‐Reperfusion Injury
Med Research, EarlyView.ABSTRACT Reperfusion therapy is the mainstay of treatment for ischemic stroke (IS) but frequently exacerbates secondary injury. Following cerebral ischemia and hypoxia, lactate accumulates markedly. Traditionally regarded as a metabolic byproduct, lactate has gained new significance with the discovery of protein lactylation. In addition to experimental
Minghui Tang +13 more
wiley +1 more source
Multiple structures of RNA polymerase II isolated from human nuclei by ChIP-CryoEM analysis
Nature CommunicationsRNA polymerase II (RNAPII) is a central transcription enzyme that exists as multiple forms with or without accessory factors, and transcribes the genomic DNA packaged in chromatin.
Tomoya Kujirai +12 more
doaj +1 more source
Changes in nucleosome occupancy occur in a chromosome specific manner
Genomics Data, 2014 In the eukaryotic nucleus, DNA is packaged into chromatin. The fundamental subunit of chromatin is the nucleosome, DNA is wrapped 1.6 times around a histone octamer core.
Brittany S. Sexton +4 more
doaj +1 more source
Direct observation of coordinated DNA movements on the nucleosome during chromatin remodelling
Nature Communications, 2019 ATP-dependent chromatin remodelling enzymes (remodellers) regulate DNA accessibility in eukaryotic genomes. Many remodellers reposition (slide) nucleosomes, however, how DNA is propagated around the histone octamer during this process is unclear. Here we
A. Sabantsev +4 more
semanticscholar +1 more source
Andrology, EarlyView.Abstract Background Myocyte enhancer factor 2 transcription factors regulate essential transcriptional programs in various cell types. The activity of myocyte enhancer factor 2 factors is modulated through interactions with cofactors, chromatin remodelers, and other regulatory proteins, which are dependent on cell context and physiological state.
Karine de Mattos +4 more
wiley +1 more source
Free energy profile for unwrapping outer superhelical turn of CENP-A nucleosome
Biophysics and Physicobiology, 2019 Eukaryotic genome is packaged in a nucleus in the form of chromatin. The fundamental structural unit of the chromatin is the protein-DNA complex, nucleosome, where DNA of about 150 bp is wrapped around a histone core almost twice.
Hidetoshi Kono +2 more
doaj +1 more source
, 2010 We investigated the effect of torsional rigidity of a semiflexible chain on the wrapping transition around a spherical core, as a model of nucleosome, the fundamental unit of chromatin.
A. Wolffe +5 more
core +1 more source
Stochastic models of nucleosome dynamics reveal regulatory rules of stimulus-induced epigenome remodeling [PDF]
, 2022 Jinsu Kim +4 more
openalex +1 more source
British Journal of Pharmacology, EarlyView.Abstract Chronic pain, marked by nociceptive sensitization and maladaptive neuroplasticity, affects 30% of the global population with escalating socioeconomic burdens. Epidemiological data show a 2‐3‐fold increase in neuropsychiatric co‐morbidities among individuals with chronic pain, where epigenetic dysregulation serves as a key mechanism linking ...
Kai Zhang +18 more
wiley +1 more source
Bio-Protocol, 2017 The basic unit of chromatin is the nucleosome, a histone octamer with 147 base pairs of DNA wrapped around it. Positions of nucleosomes relative to each other and to DNA elements have a strong impact on chromatin structure and gene activity and are ...
Zhongliang Zhao, Holger Bierhoff
doaj +1 more source