Results 141 to 150 of about 70,917 (227)

Non‐Histone Lactylation: A New Frontier in Cerebral Ischemia‐Reperfusion Injury

Med Research, Volume 2, Issue 1, Page 4-21, March 2026.
ABSTRACT Reperfusion therapy is the mainstay of treatment for ischemic stroke (IS) but frequently exacerbates secondary injury. Following cerebral ischemia and hypoxia, lactate accumulates markedly. Traditionally regarded as a metabolic byproduct, lactate has gained new significance with the discovery of protein lactylation. In addition to experimental
Minghui Tang, Yuying Mo, Zhishan Ling, Yuting Zeng, Qi Zhang, Shuqi Zheng, Shuyang Wen, Yupeng Xiao, Siying Long, Tingting Yang, Qianru Li, Wenjie Shi, Guozhi Huang, Qing Zeng   +13 more
wiley   +1 more source

Direct visualization and tracing of chromatin folding in the Drosophila embryo. [PDF]

EMBO J
Fatmaoui F, Carrivain P, Taiki F, Iusupova A, Grewe D, Hagen W, Jakob B, Victor JM, Leforestier A, Eltsov M.   +9 more
europepmc   +1 more source

Nucleosome [PDF]

, 2020
openaire   +1 more source

Ions as Architects of DNA Nanostructures: Mechanisms, Simulations, and Technological Frontiers

Small Structures, Volume 7, Issue 3, March 2026.
Ions are not merely passive electrolytes but active regulators of DNA nanostructures. This review shows how ion valence, hydration, and specificity govern electrostatic screening, correlation, and confinement, enabling DNA origami, metallized DNA, nanopores, hydrogels, DNAzymes, molecular machines, and energy devices through integrated experimental and
Sergiy Perepelytsya, Dmytro Piatnytskyi, Tetiana Bubon, Narcis Cibotariu, Aatto Laaksonen, Francesca Mocci   +5 more
wiley   +1 more source

Acetylation of H3K115 is associated with fragile nucleosomes at CpG island promoters and active regulatory sites. [PDF]

Elife
Kumar Y, Sengupta D, Friman ET, Illingworth RS, Soleil M, Fan Z, Wang H, Helin K, Gérard M, Bickmore WA.   +9 more
europepmc   +1 more source

Molecular polymorphisms that underlie trait variation in crops: Lessons learned from soybean

The Plant Genome, Volume 19, Issue 1, March 2026.
Abstract Genetic variation within a germplasm is important in crop improvement, providing a foundation for breeders to develop new varieties. Traits of agronomic and economic importance are often mapped to identify the genetic basis of observed phenotypes, oftentimes using quantitative trait locus (QTL) analysis.
Mary Jane C. Espina, Aaron J. Lorenz, Robert M. Stupar   +2 more
wiley   +1 more source

Histone Variant H2A.Z Enhances Histone and Nucleosome Dynamics. [PDF]

Mol Cell Proteomics
Dias JK, Dias PS, Alakenova R, Mariasoosai C, Claridy C, Gazi S, Torabifard H, D'Arcy S.   +7 more
europepmc   +1 more source

Drug Delivery Systems for Resiquimod to Control Myeloid‐Derived Suppressor Cells in Cancer Immunotherapy

WIREs Nanomedicine and Nanobiotechnology, Volume 18, Issue 2, March/April 2026.
Myeloid‐derived suppressor cells (MDSCs) are key contributors to cancer immunotherapy failure and major targets in new therapeutic strategies. We highlight therapeutic approaches to counteract their immunosuppressive functions and discuss recent efforts to optimize drug delivery for controlling MDSCs, focusing on resiquimod as a representative drug ...
Yanying He, Yoon Yeo
wiley   +1 more source

Structural analysis of OCT4 binding to human LIN28B nucleosomes. [PDF]

Sci Rep
Sinha KK, Halic M.
europepmc   +1 more source

Breaking barriers: transitioning from X‐ray crystallography to cryo‐EM for structural studies

Acta Crystallographica Section D, Volume 82, Issue 3, Page 253-273, March 2026.
This article describes the transition of the Glass laboratory from X‐ray crystallography to single‐particle cryo‐electron microscopy (cryo‐EM) for structural studies of ATAD2B, a large AAA+ ATPase‐ and bromodomain‐containing protein involved in chromatin regulation.
Hassan Zafar, Kiera L. Malone, Ajit K. Singh, Michael A. Cianfrocco, Karen C. Glass   +4 more
wiley   +1 more source