Results 91 to 100 of about 69,179 (216)

Membraneless Organelles and Phase Separation in Tumours: Mechanisms and Prospects

Cell Proliferation, EarlyView.
The Salient and Novel Findings: This article summarises the latest research advancements in phase separation within tumours, with a particular focus on the role and molecular mechanisms of liquid–liquid phase separation (LLPS) in tumour progression.
Hao Yang, Zhong Chu, Shuwen Han, Yuefen Pan   +3 more
wiley   +1 more source

Chromatin: a tunable spring at work inside chromosomes

, 2001
This paper focuses on mechanical aspects of chromatin biological functioning. Within a basic geometric modeling of the chromatin assembly, we give for the first time the complete set of elastic constants (twist and bend persistence lengths, stretch ...
A. E. H. Love, A. Leforestier, A. S. Belmont, A. Wolffe, A. Worcel, Annick Lesne, B. Houchmandzadeh, C. Balbi, C. Baumann, C. Bouchiat, C. L. Woodcock, C. S. O’Hern, Eli Ben-Haïm, F. Livolant, G. Janninck, H. Schiessel, I. Russo, J. Bednar, J. Marko, J. Marko, J. Marko, J. O. Thomas, J. T. Finch, J. W. Phillips, J. Widom, J. Widom, J. Yao, J. Zlatanova, Jean-Marc Victor, K. Luger, K. van Holde, K. van Holde, K. van Holde, L. M. Carruthers, L. M. Carruthers, M. Poirier, O. Kratky, P. T. Lowary, R. D. Kamien, R. R. Netz, S. B. Smith, S. H. Leuba, S. H. Leuba, S. H. Leuba, S. Przybyl, T. Odijk, T. R. Strick, V. Katritch, W. Saenger, Y. Cui, Z. Kam   +50 more
core   +1 more source

Role of Histone Deacetylase and Inhibitors in Cardiovascular Diseases

Cell Proliferation, EarlyView.
HDACs play an important role in the occurrence and development of cardiovascular diseases, such as myocardial hypertrophy, hypertension, and atherosclerosis. HDAC inhibitors have broad prospects for the treatment of CVD, and different HDAC subtypes can act through different mechanisms.
Li‐Ying Zhang, Yue‐Yue Wang, Ri Wen, Tie‐Ning Zhang, Ni Yang   +4 more
wiley   +1 more source

Transcriptome Analysis Suggested Striking Transition Around the End of Epiboly in the Gene Regulatory Network Downstream of the Oct4‐Type POU Gene in Zebrafish Embryos

Development, Growth &Differentiation, EarlyView.
Transcriptome analysis of pou5f3‐regulated genes in zebrafish embryos showed that competence to pou5f3 regulation changes significantly before and after the end of epiboly. The target genes encoded a diverse array of proteins, including transcriptional regulators and signaling molecules.
Masaaki Ikeda, Kana Kobayashi, Yukiko Nakayama‐Sadakiyo, Yuto Sato, Ayano Tobita, Mika Saito, Kyo Yamasu   +6 more
wiley   +1 more source

Computational modeling to elucidate molecular mechanisms of epigenetic memory

, 2015
How do mammalian cells that share the same genome exist in notably distinct phenotypes, exhibiting differences in morphology, gene expression patterns, and epigenetic chromatin statuses?
Alsing, Andrews, Ang, Angel, Arnold, Bannister, Barth, Beisel, Benecke, Bhattacharya, Binder, Black, Buscaino, Bushey, Canzio, Cowieson, David-Rus, Dayarian, Deal, Dodd, Fonseca, Freddolino, Gaffney, Grauffel, Greer, Grewal, Grigoryev, Hanna, Hathaway, Henikoff, Herranz, Hodges, Jacobs, Korolev, Korolev, Kouzarides, Ku, Kulaeva, Lin, Margreitter, Margueron, Mendenhall, Muller, Papp, Pasque, Peinado, Piana, Potoyan, Prohaska, Raghavan, Rohlf, Sanbonmatsu, Sanli, Schwab, Schwammle, Sedighi, So, Sontag, Steffen, Takahashi, Teif, Thon, Wocjan, Xu, Yang, Yuan, Zee, Zhang, Zhang   +68 more
core   +1 more source

Pathogenic variants in chromatin‐related genes: Linking immune dysregulation to neuroregression and acute neuropsychiatric disorders

Developmental Medicine &Child Neurology, EarlyView.
Chromatin machinery influences how DNA is ‘wrapped’ around histones in the nucleosome of immune and brain cells. Plain language summary: https://onlinelibrary.wiley.com/doi/10.1111/dmcn.16299 Abstract We report eight children with de novo pathogenic DNA variants in chromatin‐related genes: MORC2, CHD7, KANSL1, KMT2D, ZMYND11, HIST1HIE, EP300, and KMT2B.
Russell C. Dale, Shekeeb Mohammad, Velda X. Han, Hiroya Nishida, Himanshu Goel, Stuart G. Tangye, Georgina Hollway, Esther Tantsis, Deepak Gill, Shrujna Patel, Chromatin Immune‐Brain Group, Michael Lonergan, Melanie Wong, Kavitha Kothur, Erica Tsang   +14 more
wiley   +1 more source

DNA Spools under Tension

, 2003
DNA-spools, structures in which DNA is wrapped and helically coiled onto itself or onto a protein core are ubiquitous in nature. We develop a general theory describing the non-equilibrium behavior of DNA-spools under linear tension.
C. G. Baumann, E. Evans, E. Evans, H. Schiessel, H. Yin, I. M. Kulić, J. F. Marko, K. B. Thurmond, R. Bruinsma   +8 more
core   +1 more source

Cardioprotective effects of the extracellular chaperone clusterin in acute myocardial infarction

European Journal of Clinical Investigation, EarlyView.
In vivo, CLU−/− mice were more susceptible to acute myocardial infarction than CLU+/+ mice. Moreover, inflammation and histone levels were significantly increased in CLU−/− mice compared to CLU+/+ mice following ischemia/reperfusion. In vitro, CLU protects cardiomyocytes from histone‐ and/or hypoxia‐induced cell death.
Louwana Allawa, Antoine Poirier, Pascale Pignon, Justine Beaumont, Lucie Lebeau, Agnès Barbelivien, Thomas Bochaton, Céline Beauvillain, Daniel Henrion, Yves Delneste, Pascale Jeannin, Fabrice Prunier, Sophie Tamareille   +12 more
wiley   +1 more source

Cell type mapping of mild malformations of cortical development with oligodendroglial hyperplasia in epilepsy using single‐nucleus multiomics

Epilepsia, EarlyView.
Abstract Objective Mild malformations of cortical development with oligodendroglial hyperplasia in epilepsy (MOGHE) are brain lesions associated with focal epilepsy and characterized by increased oligodendroglial density, heterotopic neurons, and hypomyelination in the white matter.
Isabella C. Galvão, Manuela Lemoine, Ludmyla Kandratavicius, Clarissa L. Yasuda, Marina K. M. Alvim, Enrico Ghizoni, Ingmar Blümcke, Fernando Cendes, Fabio Rogerio, Iscia Lopes‐Cendes, Diogo F. T. Veiga   +10 more
wiley   +1 more source

A cellular model of TDP‐43 induces phosphorylated TDP‐43 aggregation with distinct changes in solubility and autophagy dysregulation

The FEBS Journal, EarlyView.
TDP‐43 protein plays a pathological role in sporadic and familial amyotrophic lateral sclerosis (ALS). Here, we developed a cellular model overexpressing TDP‐43 with three mutations linked to familial ALS, termed ‘3X‐TDP‐43’. Mutant 3X‐TDP‐43 expression showed deficits in autophagy flux and colocalization with stress granules.
Matthew B. Dopler, Muhammad I. Abeer, Sanaz Arezoumandan, Keyshawn Cox, Tyler L. Petersen, Esther H. Daniel, Carlton L. Cannon III, Angelica Bautista, Kennedy D. Blancher, Alysia M. Bland, Kylie J. Bond, Dominque A. Davis, Jessica M. Francois, Eliana J. McCray, Justin M. Morgan, Jessica L. Pulliam, Zymir A. Robinson, Mykia J. Taylor, James A. Dowell, Nigel J. Cairns, Michael A. Gitcho   +20 more
wiley   +1 more source