Results 91 to 100 of about 71,049 (222)
PRDM9 binding organizes hotspot nucleosomes and limits Holliday junction migration
Genome Research, 2014 In mammals, genetic recombination during meiosis is limited to a set of 1- to 2-kb regions termed hotspots. Their locations are predominantly determined by the zinc finger protein PRDM9, which binds to DNA in hotspots and subsequently uses its SET domain
C. Baker +4 more
semanticscholar +1 more source
Human nucleosomes: special role of CG dinucleotides and Alu-nucleosomes
BMC Genomics, 2011 Background The periodical occurrence of dinucleotides with a period of 10.4 bases now is undeniably a hallmark of nucleosome positioning. Whereas many eukaryotic genomes contain visible and even strong signals for periodic distribution of dinucleotides ...
Trifonov Edward N +2 more
doaj +1 more source
Controls of nucleosome positioning in the human genome.
PLoS Genetics, 2012 Nucleosomes are important for gene regulation because their arrangement on the genome can control which proteins bind to DNA. Currently, few human nucleosomes are thought to be consistently positioned across cells; however, this has been difficult to ...
Daniel J Gaffney +8 more
doaj +1 more source
Nucleosomes Shape DNA Polymorphism and Divergence
PLoS Genetics, 2014 An estimated 80% of genomic DNA in eukaryotes is packaged as nucleosomes, which, together with the remaining interstitial linker regions, generate higher order chromatin structures [1].
Sasha A. Langley, G. Karpen, C. Langley
semanticscholar +1 more source
DNA accessibility of chromatosomes quantified by automated image analysis of AFM data
Scientific Reports, 2019 DNA compaction and accessibility in eukaryotes are governed by nucleosomes and orchestrated through interactions between DNA and DNA-binding proteins.
Martin Würtz +7 more
doaj +1 more source
A barrier nucleosome model for statistical positioning of nucleosomes throughout the yeast genome.
Genome Research, 2008 Most nucleosomes are well-organized at the 5' ends of S. cerevisiae genes where "-1" and "+1" nucleosomes bracket a nucleosome-free promoter region (NFR). How nucleosomal organization is specified by the genome is less clear.
Travis N. Mavrich +8 more
semanticscholar +1 more source
Composite macroH2A/NRF-1 Nucleosomes Suppress Noise and Generate Robustness in Gene Expression
Cell Reports, 2015 The histone variant macroH2A (mH2A) has been implicated in transcriptional repression, but the molecular mechanisms that contribute to global mH2A-dependent genome regulation remain elusive.
Matthieu D. Lavigne +7 more
doaj +1 more source
Chromatin and nucleosome structure [PDF]
, 1976 Richard Mandel, Gerald D. Fasman
openalex +1 more source
The Chromatin Organization of an Eukaryotic Genome : Sequence Specific+ Statistical=Combinatorial (Extended Abstract) [PDF]
arXiv, 2012 Nucleosome organization in eukaryotic genomes has a deep impact on gene function. Although progress has been recently made in the identification of various concurring factors influencing nucleosome positioning, it is still unclear whether nucleosome positions are sequence dictated or determined by a random process.
arxiv
Nature Genetics, 2009 To understand how chromatin structure is organized by different histone variants, we have measured the genome-wide distribution of nucleosome core particles (NCPs) containing the histone variants H3.3 and H2A.Z in human cells.
C. Jin +6 more
semanticscholar +1 more source