Results 101 to 110 of about 69,179 (216)

Epigenetic control of cell identities from epiblast to gastrulation

The FEBS Journal, EarlyView.
In this review, we present and contextualize current knowledge about the roles of epigenetic modifiers during the development of mouse epiblast to gastrulation stage. The epigenetic regulation of enhancer and promoter elements by DNA methylation, histone modifications, and chromatin accessibility in concert with lineage‐specific transcription factors ...
Katrin M. Schüle, Simone Probst
wiley   +1 more source

Interaction of TFAP2A with the Ku70/80 complex is crucial for HIF‐dependent activation of hypoxia‐inducible genes

The FEBS Journal, EarlyView.
Under normoxic conditions, the SUMOylated fraction of TFAP2A cannot interact with the Ku70/Ku80 complex, nor it can bind to chromatin. The unSUMOylated fraction pre‐occupies the chromatin of a subset of hypoxia‐induced genes together with the Ku70/Ku80 complex for basal euchromatin formation. Under hypoxic conditions, the SUMOylation equilibrium shifts
Amalia Kanoura, Antonis Giakountis, Chrysa Filippopoulou, Angeliki Karagiota, George Stamatakis, Martina Samiotaki, George Panayotou, George Simos, Georgia Chachami   +8 more
wiley   +1 more source

Transcription‐coupled repair: tangled up in convoluted repair

The FEBS Journal, EarlyView.
In this review, we discuss recent findings derived from diverse genomic, biochemical and structural, imaging, and functional studies (B–E) that culminated in deep mechanistic insight (A) into the vital cellular process of transcription‐coupled nucleotide excision repair (TC‐NER).
Diana A. Llerena Schiffmacher, Yun Jin Pai, Alex Pines, Wim Vermeulen   +3 more
wiley   +1 more source

Pathological significance of intranuclear structures in liver biopsy samples

Hepatology Research, EarlyView.
Schematic representation of the potential significance of three distinct nuclear structures. Glycogenated nuclei reflects excessive glycogen accumulation in the hepatocytes. Nucleoplasmic lipid droplets form in the nucleus during hepatocyte injury. Cytoplasmic lipid droplets in the nucleoplasmic reticulum are suppressed when there is excessive fat ...
Norihiro Imai, Yuki Ohsaki, Jinglei Cheng, Hanna Kawecka, Jingjing Zhang, Fumitaka Mizuno, Taku Tanaka, Shinya Yokoyama, Kenta Yamamoto, Takanori Ito, Yoji Ishizu, Takashi Honda, Tetsuya Ishikawa, Michał Woźniak, Hiroaki Wake, Hiroki Kawashima   +15 more
wiley   +1 more source

Chromatin Structure in the Cellular Slime Mold Dictyostelium discoideum [PDF]

, 1978
The structure of Dictyostelium discoideum chromatin has been studied by the following techniques: electron microscopy, staphylococcal nuclease digestion, acrylamide gel electrophoresis, sucrose gradient centrifugation, and melting.
Bakke, Antony C., Bonner, James, Wu, Jung-Rung   +2 more
core  

Nucleosomes at the Dawn of Eukaryotes

Genome Biology and Evolution
Abstract Genome regulation in eukaryotes revolves around the nucleosome, the fundamental building block of eukaryotic chromatin. Its constituent parts, the four core histones (H3, H4, H2A, H2B), are universal to eukaryotes. Yet despite its exceptional conservation and central role in orchestrating transcription, repair, and other DNA ...
Hocher, A, Warnecke, T
openaire   +2 more sources

Neutrophil Extracellular Traps Are Widely Distributed Across Lesional and Perilesional Hidradenitis Suppurativa Skin, and Elevated Serum NET Markers Associate With Moderate to Severe HS Disease

International Journal of Dermatology, EarlyView.
Increased NET markers are detected in HS skin and blood. Neutrophils are scarce in healthy skin but infiltrate lesions of hidradenitis suppurativa (HS) patients. Activated neutrophils release proinflammatory neutrophil extracellular traps (NETs). The NET marker CitH3 was widely distributed across both lesional and perilesional regions of HS skin but ...
Stephanie C. M. van Dalen, Josephine W. J. Stein, Tirza Bruurmijn, Martyn L. Foster, Renato G. S. Chirivi, Maarten van der Linden, Helmuth van Es, Jacek C. Szepietowski, Piotr K. Krajewski, Kelsey R. van Straalen, Errol P. Prens, John R. Ingram, Eric Meldrum   +12 more
wiley   +1 more source

The Roles of Plasticity and Selection in Rapid Phenotypic Changes at the Pacific Oyster Invasion Front in Europe

Molecular Ecology, EarlyView.
ABSTRACT Invasive species present significant management challenges worldwide due to their ability to rapidly adapt to novel environments. The Pacific oyster Crassostrea gigas, a globally distributed invasive species, arrived in western Sweden in 2006 but has not yet colonised the low salinity waters of the Baltic Sea, presumably because low salinities
Alexandra Kinnby, Chloé Robert, Jonathan N. Havenhand, Göran Broström, Luc Bussière, Pierre De Wit   +5 more
wiley   +1 more source

BAF60/SWP73 subunits define subclasses of SWI/SNF chromatin remodelling complexes in Arabidopsis

New Phytologist, EarlyView.
Summary Evolutionarily conserved switch‐defective/sucrose nonfermentable (SWI/SNF) ATP‐dependent chromatin remodelling complexes (CRCs) alter nucleosome positioning and chromatin states, affecting gene expression to regulate important processes such as proper development and hormonal signalling pathways.
Sebastian P. Sacharowski, Szymon Kubala, Pawel Cwiek, Jaroslaw Steciuk, Dominika Gratkowska‐Zmuda, Paulina Oksinska, Ernest Bucior, Anna T. Rolicka, Monika Ciesla, Klaudia Nowicka, Saleh Alseekh, Takayuki Tohge, Patrick Giavalisco, Dorota L. Zugaj, Sara C. Stolze, Anne Harzen, Rainer Franzen, Bruno Huettel, Elzbieta Grzesiuk, Mohammad‐Reza Hajirezaei, Hirofumi Nakagami, Csaba Koncz, Alisdair R. Fernie, Tomasz J. Sarnowski   +23 more
wiley   +1 more source

Exploring the untapped potential of single‐cell and spatial omics in plant biology

New Phytologist, EarlyView.
Summary Advances in single‐cell and spatial omics technologies have revolutionised biology by revealing the diverse molecular states of individual cells and their spatial organization within tissues. The field of plant biology has widely adopted single‐cell transcriptome and chromatin accessibility profiling and spatial transcriptomics, which extend ...
Tatsuya Nobori
wiley   +1 more source