Results 171 to 180 of about 72,215 (324)
Nucleosome arrangement with regard to DNA base composition.
, 1979 Patrice Nelson +2 more
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Cell cycle-dependent changes in conformation and composition of nucleosomes containing human histone gene sequences [PDF]
, 1987 Richard Sterner +3 more
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Role of Histone Deacetylase and Inhibitors in Cardiovascular Diseases
Cell Proliferation, EarlyView.HDACs play an important role in the occurrence and development of cardiovascular diseases, such as myocardial hypertrophy, hypertension, and atherosclerosis. HDAC inhibitors have broad prospects for the treatment of CVD, and different HDAC subtypes can act through different mechanisms.
Li‐Ying Zhang +4 more
wiley +1 more source
Cardioprotective effects of the extracellular chaperone clusterin in acute myocardial infarction
European Journal of Clinical Investigation, EarlyView.In vivo, CLU−/− mice were more susceptible to acute myocardial infarction than CLU+/+ mice. Moreover, inflammation and histone levels were significantly increased in CLU−/− mice compared to CLU+/+ mice following ischemia/reperfusion. In vitro, CLU protects cardiomyocytes from histone‐ and/or hypoxia‐induced cell death.
Louwana Allawa +12 more
wiley +1 more source
Protein D1 preferentially binds A + T-rich DNA in vitro and is a component of Drosophila melanogaster nucleosomes containing A + T-rich satellite DNA. [PDF]
, 1982 Louis Levinger, Alexander Varshavsky
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Epilepsia, EarlyView.Abstract Objective Mild malformations of cortical development with oligodendroglial hyperplasia in epilepsy (MOGHE) are brain lesions associated with focal epilepsy and characterized by increased oligodendroglial density, heterotopic neurons, and hypomyelination in the white matter.
Isabella C. Galvão +10 more
wiley +1 more source
The FEBS Journal, EarlyView.TDP‐43 protein plays a pathological role in sporadic and familial amyotrophic lateral sclerosis (ALS). Here, we developed a cellular model overexpressing TDP‐43 with three mutations linked to familial ALS, termed ‘3X‐TDP‐43’. Mutant 3X‐TDP‐43 expression showed deficits in autophagy flux and colocalization with stress granules.
Matthew B. Dopler +20 more
wiley +1 more source
Rat liver HMG1: a physiological nucleosome assembly factor. [PDF]
, 1984 Catherine Bonne-Andréa +3 more
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Epigenetic control of cell identities from epiblast to gastrulation
The FEBS Journal, EarlyView.In this review, we present and contextualize current knowledge about the roles of epigenetic modifiers during the development of mouse epiblast to gastrulation stage. The epigenetic regulation of enhancer and promoter elements by DNA methylation, histone modifications, and chromatin accessibility in concert with lineage‐specific transcription factors ...
Katrin M. Schüle, Simone Probst
wiley +1 more source