Results 171 to 180 of about 74,179 (293)

Epigenomics‐guided precision oncology: Chromatin variants in prostate tumor evolution

International Journal of Cancer, Volume 158, Issue 2, Page 314-332, 15 January 2026.
Abstract Prostate cancer is a common malignancy that in 5%–30% leads to treatment‐resistant and highly aggressive disease. Metastasis‐potential and treatment‐resistance is thought to rely on increased plasticity of the cancer cells—a mechanism whereby cancer cells alter their identity to adapt to changing environments or therapeutic pressures to create
Kira Furlano, Tina Keshavarzian, Nadine Biernath, Annika Fendler, Maria de Santis, Joachim Weischenfeldt, Mathieu Lupien   +6 more
wiley   +1 more source

H2A.Z and H3:K56Q Affect Transcription Through Chromatin and Yeast FACT-Dependent Nucleosome Unfolding. [PDF]

Int J Mol Sci
Afonin D, Ukrainets ER, Kotova E, Gerasimova NS, Armeev GA, Kirpichnikov MP, Feofanov AV, Studitsky VM.   +7 more
europepmc   +1 more source

Enhancer‐dependent gene regulation in space, time, and malignancies

International Journal of Cancer, Volume 158, Issue 2, Page 357-367, 15 January 2026.
Abstract Control of cell‐type‐specific gene activation requires the coordinated activity of distal regulatory elements, including enhancers, whose inputs must be temporally integrated. Dysregulation of this regulatory capacity, such as aberrant usage of enhancers, can result in malignant transformation of cells.
Belinda Blum, Victoria Dachtler, Angelika Feldmann   +2 more
wiley   +1 more source

Linker histone H1.5 contributes to centromere integrity. [PDF]

Nucleic Acids Res
Saha A, Bui M, Melters DP, Arunkumar G, Baek S, Bentahar RS, Dalal Y.   +6 more
europepmc   +1 more source

Therapeutic targeting of chromatin alterations in leukemia and solid tumors

International Journal of Cancer, Volume 158, Issue 2, Page 382-408, 15 January 2026.
Abstract Alterations in chromatin conformation and post‐translational modification of histones have become increasingly recognized as critical drivers of cancer development, progression, and therapy resistance. Recent advances in drug development have led to the establishment of several highly selective small molecule inhibitors, several of which are ...
Florian Perner, Tobias Berg, Daniel Sasca, Sophie‐Luise Mersiowsky, Jayant Y. Gadrey, Johanna Thomas, Michael W. M. Kühn, Michael Lübbert   +7 more
wiley   +1 more source

Cryo-EM structures of NHEJ assemblies with nucleosomes. [PDF]

Nat Commun
Hall C, Frit P, Kefala-Stavridi A, Pelletier A, Hardwick SW, Amin H, Bilyard MK, Maia De Oliviera T, Tariq A, Zahid S, Chirgadze DY, Balasubramanian S, Meek K, Ropars V, Charbonnier JB, Modesti M, Calsou P, Britton S, Blundell TL, Schalch T, Chaplin AK.   +20 more
europepmc   +1 more source

Epigenetic reprogramming in multiple myeloma—Challenges and opportunities

International Journal of Cancer, Volume 158, Issue 2, Page 423-432, 15 January 2026.
Abstract In cancer, mutational processes act in concert with epigenetic reprogramming to endow malignant cells with hallmark properties that underpin tumorigenesis. Compared with the relatively rigid and slow processes of genetic evolution, the plastic nature of chromatin enables cells to adapt to a changing environment more rapidly.
Subhasree Kumar, Lev M. Kats, Emily Gruber   +2 more
wiley   +1 more source

Predictive Value of dsDNA and Nucleosomes as Neutrophil Extracellular Traps-Related Biomarkers for COVID-19 in Older Patients

Journal of Inflammation Research
Xudong Cui,1,* Tiewei Li,2,* Jingping Yang,3 Xiaojuan Li,2 Pengfei Xuan,3 Hongyan Wang3 1Respiratory and Critical Care Medicine Department, Inner Mongolia Baogang Hospital, Inner Mongolia Medical University, Hohhot, People’s Republic of China ...
Cui X, Li T, Yang J, Li X, Xuan P, Wang H   +5 more
doaj  

CDCA7 facilitates MET1-mediated CG DNA methylation maintenance in centromeric heterochromatin via linker histone H1. [PDF]

Proc Natl Acad Sci U S A
Wang S, Li T, Naish M, Chuang R, Lin EK, Fonkalsrud C, He Y, Feng S, Henderson IR, Jacobsen SE.   +9 more
europepmc   +1 more source

Mechanical disruption of individual nucleosomes reveals a reversible multistage release of DNA

, 2002
Brent D. Brower‐Toland, Corey L. Smith, Richard Cheng-I Yeh, John T. Lis, Craig L. Peterson, Michelle D. Wang   +5 more
openalex   +1 more source