Aging Cell, Volume 25, Issue 6, June 2026.This study demonstrates that α‐synuclein expression stabilizes the proteasome activator Blm10, thereby linking α‐synuclein stress to changes in proteasome composition. Blm10/PA200‐capped 20S proteasomes efficiently degrade both monomeric and oligomeric α‐synuclein and remain resistant to α‐synuclein‐induced inhibition.
Tariq T. Ali +7 more
wiley +1 more source
Cleavage of histone H2A during embryonic stem cell differentiation destabilizes nucleosomes to counteract gene activation. [PDF]
J Biol ChemCoradin M +13 more
europepmc +1 more source
The Evolving Landscape of Clinical Aging Clocks: From Epigenetic to Multi‐Omics Integration
Aging Cell, Volume 25, Issue 6, June 2026.Multi‐omics aging clocks capture biological heterogeneity beyond single‐omics models, improving risk stratification. Key challenges include unknown biological meaning, timescale mismatches, and validation gaps. Future clocks must distinguish pathological damage from adaptive remodeling—damage accumulation is the most actionable target for anti‐aging ...
Liying Liu +13 more
wiley +1 more source
Structural characterisation of chromatin remodelling intermediates supports linker DNA-dependent product inhibition as a mechanism for nucleosome spacing. [PDF]
ElifeHughes AL +2 more
europepmc +1 more source
Intrinsic specificity of a ‘core’ TIP60 acetyltransferase complex in Drosophila
The FEBS Journal, Volume 293, Issue 11, Page 3259-3273, June 2026.The intrinsic substrate selectivity of the Drosophila TIP60‐core acetyltransferase was determined using synthetic nucleosome arrays. Targeted mass spectrometry revealed site‐specific acetylation of histones H2A, H2A.V, and H4, uncovering distinct acetylation rates and patterns across individual lysines.
Silke Krause +5 more
wiley +1 more source
A revised model for PHF20L1 Tudor function: DNA binding overrides methylation selectivity on nucleosomes. [PDF]
J Biol ChemHuang X +12 more
europepmc +1 more source
Automodification of N‐terminal serine residues facilitates PARP2 release from DNA
The FEBS Journal, Volume 293, Issue 11, Page 3274-3287, June 2026.PARP2 is involved in detecting DNA damage and its N‐terminal role is largely unknown. Based on biochemical and biophysical data, our findings suggest that in the presence of HPF1, N‐terminal serine 8 and 73 are enriched in auto‐ADP‐ribosylation. Our results provide insight into the mechanistic role of PARP2 N‐terminus in the PARylation‐dependent ...
Saurabh Singh Dhakar +6 more
wiley +1 more source
An experimentally-informed polymer model reveals high resolution organization of genomic loci. [PDF]
Nat CommunMittal R, Heermann DW, Bhattacherjee A.
europepmc +1 more source
Regulation of PHOX2B gene expression by the long non‐coding natural antisense RNA PHOX2B‐AS1
The FEBS Journal, Volume 293, Issue 12, Page 3502-3527, June 2026.PHOX2B is a transcription factor essential for autonomic nervous system development. We identify and characterize PHOX2B‐AS1, a human long non‐coding antisense transcript at the PHOX2B locus, along with its murine counterpart. Our findings reveal bidirectional transcription and reciprocal regulation: PHOX2B activates PHOX2B‐AS1, whereas PHOX2B‐AS1 ...
Simona Di Lascio +12 more
wiley +1 more source
Plenary Abstracts Session & Oral Presentations
HemaSphere, Volume 10, Issue S1, June 2026.
wiley +1 more source