Results 41 to 50 of about 74,179 (293)
eLife, 2019 Tardigrades, also known as water bears, are animals that can survive extreme conditions. The tardigrade Ramazzottius varieornatus contains a unique nuclear protein termed Dsup, for damage suppressor, which can increase the resistance of human cells to ...
C. Chavez +4 more
semanticscholar +1 more source
Epigenetics, 2018 Previous work in Saccharomyces cerevisiae identified three residues located in close proximity to each other on the side of the nucleosome whose integrity is required for proper association of the Spt16 component of the FACT complex across transcribed ...
Eugene Nyamugenda +8 more
doaj +1 more source
Proceedings of the National Academy of Sciences of the United States of America, 2019 Significance Nucleosomes are the base units that organize eukaryotic genomes. Besides the canonical histone, histone variants create unique local chromatin domains that fine-tune transcription, replication, DNA damage repair, and faithful chromosome ...
Daniël P. Melters +6 more
semanticscholar +1 more source
DDM1 and Lsh remodelers allow methylation of DNA wrapped in nucleosomes
eLife, 2017 Cytosine methylation regulates essential genome functions across eukaryotes, but the fundamental question of whether nucleosomal or naked DNA is the preferred substrate of plant and animal methyltransferases remains unresolved. Here, we show that genetic
David B. Lyons, Daniel Zilberman
semanticscholar +1 more source
DNA sliding in nucleosomes via twist defect propagation revealed by molecular simulations
Nucleic Acids Research, 2018 While nucleosomes are highly stable structures as fundamental units of chromatin, they also slide along the DNA, either spontaneously or by active remodelers.
G. Brandani +3 more
semanticscholar +1 more source
Genes & Development, 2018 Here, Rawal et al. analyzed Gcn4-induced genes in mutants lacking the catalytic subunits of SWI/SNF or RSC and uncovered cooperation between these remodelers in evicting nucleosomes from different locations in the promoter and repositioning the +1 ...
Yashpal Rawal +6 more
semanticscholar +1 more source
The role of histone modifications in transcription regulation upon DNA damage
FEBS Letters, EarlyView.This review discusses the critical role of histone modifications in regulating gene expression during the DNA damage response (DDR). By modulating chromatin structure and recruiting repair factors, these post‐translational modifications fine‐tune transcriptional programmes to maintain genomic stability.
Angelina Job Kolady, Siyao Wang
wiley +1 more source
Circulating Nucleosomes and Histones in the Development of Lung Injury and Sepsis
Current Issues in Molecular BiologyCellular nucleosomes—the structural and functional units of chromatin—are inherently present in cells. During cellular damage or cell death, nucleosomes are released into circulation, either actively or passively.
Saugata Dutta +5 more
doaj +1 more source
PLoS ONE, 2021 The most basic level of eukaryotic gene regulation is the presence or absence of nucleosomes on DNA regulatory elements. In an effort to elucidate in vivo nucleosome patterns, in vitro studies are frequently used.
David A Bates +7 more
doaj +1 more source
Single molecule analysis of CENP-A chromatin by high-speed atomic force microscopy
eLife, 2023 Chromatin accessibility is modulated in a variety of ways to create open and closed chromatin states, both of which are critical for eukaryotic gene regulation.
Daniël P Melters +4 more
doaj +1 more source