Results 41 to 50 of about 104,131 (352)

Acute depletion of the ARID1A subunit of SWI/SNF complexes reveals distinct pathways for activation and repression of transcription

open access: yesCell Reports, 2021
Summary: The ARID1A subunit of SWI/SNF chromatin remodeling complexes is a potent tumor suppressor. Here, a degron is applied to detect rapid loss of chromatin accessibility at thousands of loci where ARID1A acts to generate accessible minidomains of ...
Seraina Blümli   +13 more
doaj  

Quantitative test of the barrier nucleosome model for statistical positioning of nucleosomes up- and downstream of transcription start sites [PDF]

open access: yes, 2010
The positions of nucleosomes in eukaryotic genomes determine which parts of the DNA sequence are readily accessible for regulatory proteins and which are not.
A Flaus   +46 more
core   +5 more sources

Nucleosomes and neutrophil extracellular traps in septic and burn patients [PDF]

open access: yes, 2017
NETosis is a host defense mechanism associated with inflammation and tissue damage. Experimental models show that platelets and von Willebrand factor (VWF) are key elements for intravascular NETosis. We determined NETosis in septic and burn patients at 1
Carestia, Agostina   +8 more
core   +1 more source

Nucleosomes inhibit target cleavage by CRISPR-Cas9 in vivo

open access: yesProceedings of the National Academy of Sciences of the United States of America, 2018
Significance The efficiency of genome editing with CRISPR-Cas9 can vary widely at different targets and in different cells. Some of this variability may be due to the inherent quality of different guide RNAs, but it may also depend on the cellular ...
R. Yarrington   +4 more
semanticscholar   +1 more source

Epichromatin and chromomeres: a ‘fuzzy’ perspective [PDF]

open access: yesOpen Biology, 2018
‘Epichromatin’, the surface of chromatin beneath the interphase nuclear envelope (NE) or at the surface of mitotic chromosomes, was discovered by immunostaining with a specific bivalent mouse monoclonal anti-nucleosome antibody (mAb PL2-6). ‘Chromomeres’,
Donald E. Olins, Ada L. Olins
doaj   +1 more source

PuFFIN--a parameter-free method to build nucleosome maps from paired-end reads. [PDF]

open access: yes, 2014
BackgroundWe introduce a novel method, called PuFFIN, that takes advantage of paired-end short reads to build genome-wide nucleosome maps with larger numbers of detected nucleosomes and higher accuracy than existing tools. In contrast to other approaches
Bunnik, Evelien M   +3 more
core   +4 more sources

BRD4 is a Histone Acetyltransferase that Evicts Nucleosomes from Chromatin

open access: yesNature Structural &Molecular Biology, 2016
Bromodomain protein 4 (BRD4) is a chromatin-binding protein implicated in cancer and autoimmune diseases that functions as a scaffold for transcription factors at promoters and super-enhancers.
B. N. Devaiah   +8 more
semanticscholar   +1 more source

Charged residues on the side of the nucleosome contribute to normal Spt16-gene interactions in budding yeast

open access: yesEpigenetics, 2018
Previous work in Saccharomyces cerevisiae identified three residues located in close proximity to each other on the side of the nucleosome whose integrity is required for proper association of the Spt16 component of the FACT complex across transcribed ...
Eugene Nyamugenda   +8 more
doaj   +1 more source

Precise genome-wide mapping of single nucleosomes and linkers in vivo

open access: yesGenome Biology, 2018
We developed a chemical cleavage method that releases single nucleosome dyad-containing fragments, allowing us to precisely map both single nucleosomes and linkers with high accuracy genome-wide in yeast.
Răzvan V. Chereji   +3 more
semanticscholar   +1 more source

Nucleosomes in serum as a marker for cell death [PDF]

open access: yes, 2001
The concentration of nucleosomes is elevated in blood of patients with diseases which are associated with enhanced cell death. In order to detect these circulating nucleosomes, we used the Cell Death Detection-ELISA(Plus) (CDDE) from Roche Diagnostics ...
Anker P   +15 more
core   +1 more source

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