Results 41 to 50 of about 104,131 (352)
Summary: The ARID1A subunit of SWI/SNF chromatin remodeling complexes is a potent tumor suppressor. Here, a degron is applied to detect rapid loss of chromatin accessibility at thousands of loci where ARID1A acts to generate accessible minidomains of ...
Seraina Blümli+13 more
doaj
Quantitative test of the barrier nucleosome model for statistical positioning of nucleosomes up- and downstream of transcription start sites [PDF]
The positions of nucleosomes in eukaryotic genomes determine which parts of the DNA sequence are readily accessible for regulatory proteins and which are not.
A Flaus+46 more
core +5 more sources
Nucleosomes and neutrophil extracellular traps in septic and burn patients [PDF]
NETosis is a host defense mechanism associated with inflammation and tissue damage. Experimental models show that platelets and von Willebrand factor (VWF) are key elements for intravascular NETosis. We determined NETosis in septic and burn patients at 1
Carestia, Agostina+8 more
core +1 more source
Nucleosomes inhibit target cleavage by CRISPR-Cas9 in vivo
Significance The efficiency of genome editing with CRISPR-Cas9 can vary widely at different targets and in different cells. Some of this variability may be due to the inherent quality of different guide RNAs, but it may also depend on the cellular ...
R. Yarrington+4 more
semanticscholar +1 more source
Epichromatin and chromomeres: a ‘fuzzy’ perspective [PDF]
‘Epichromatin’, the surface of chromatin beneath the interphase nuclear envelope (NE) or at the surface of mitotic chromosomes, was discovered by immunostaining with a specific bivalent mouse monoclonal anti-nucleosome antibody (mAb PL2-6). ‘Chromomeres’,
Donald E. Olins, Ada L. Olins
doaj +1 more source
PuFFIN--a parameter-free method to build nucleosome maps from paired-end reads. [PDF]
BackgroundWe introduce a novel method, called PuFFIN, that takes advantage of paired-end short reads to build genome-wide nucleosome maps with larger numbers of detected nucleosomes and higher accuracy than existing tools. In contrast to other approaches
Bunnik, Evelien M+3 more
core +4 more sources
BRD4 is a Histone Acetyltransferase that Evicts Nucleosomes from Chromatin
Bromodomain protein 4 (BRD4) is a chromatin-binding protein implicated in cancer and autoimmune diseases that functions as a scaffold for transcription factors at promoters and super-enhancers.
B. N. Devaiah+8 more
semanticscholar +1 more source
Previous work in Saccharomyces cerevisiae identified three residues located in close proximity to each other on the side of the nucleosome whose integrity is required for proper association of the Spt16 component of the FACT complex across transcribed ...
Eugene Nyamugenda+8 more
doaj +1 more source
Precise genome-wide mapping of single nucleosomes and linkers in vivo
We developed a chemical cleavage method that releases single nucleosome dyad-containing fragments, allowing us to precisely map both single nucleosomes and linkers with high accuracy genome-wide in yeast.
Răzvan V. Chereji+3 more
semanticscholar +1 more source
Nucleosomes in serum as a marker for cell death [PDF]
The concentration of nucleosomes is elevated in blood of patients with diseases which are associated with enhanced cell death. In order to detect these circulating nucleosomes, we used the Cell Death Detection-ELISA(Plus) (CDDE) from Roche Diagnostics ...
Anker P+15 more
core +1 more source