Results 51 to 60 of about 74,179 (293)
Circulating Nucleosomes and Nucleosome Modifications as Biomarkers in Cancer
Cancers, 2017 Traditionally the stratification of many cancers involves combining tumour and clinicopathological features (e.g., patient age; tumour size, grade, receptor status and location) to inform treatment options and predict recurrence risk and survival ...
P. McAnena, James A. L. Brown, M. Kerin
semanticscholar +1 more source
Integration of circadian and hypoxia signaling via non‐canonical heterodimerization
FEBS Letters, EarlyView.CLOCK, BMAL1, and HIFs are basic helix‐loop‐helix and Per‐Arnt‐Sim domain (bHLH‐PAS) proteins, which function as transcription factors. bHLH‐PAS proteins are designated in two classes. Many class I proteins are regulated by environmental signals via their PAS domains, but such signals have not been identified for all.
Sicong Wang, Katja A. Lamia
wiley +1 more source
Making better CRISPR libraries
eLife, 2016 A new algorithm improves the performance of CRISPR-based genetic screens in mammals.
Shiyou Zhu, Wensheng Wei
doaj +1 more source
Extracellular histones, cell-free DNA, or nucleosomes: differences in immunostimulation
Cell Death and Disease, 2016 In inflammation, extensive cell death may occur, which results in the release of chromatin components into the extracellular environment. Individually, the purified chromatin components double stranded (ds)DNA and histones have been demonstrated, both in
G. Marsman, S. Zeerleder, B. Luken
semanticscholar +1 more source
Molecular Oncology, EarlyView.Detection of extrachromosomal circular DNA (eccDNA) in plasma samples from EGFR‐mutated non‐small cell lung cancer patients. Plasma was collected before and during treatment with the EGFR‐tyrosine kinase inhibitor osimertinib. Plasma eccDNA was detected in all cancer samples, and the presence of the EGFR gene on eccDNA serves as a potential biomarker ...
Simone Stensgaard +5 more
wiley +1 more source
eLife, 2016 We recently found that nucleosomes directly block access of CRISPR/Cas9 to DNA (Horlbeck et al., 2016). Here, we build on this observation with a comprehensive algorithm that incorporates chromatin, position, and sequence features to accurately predict ...
Max A Horlbeck +10 more
doaj +1 more source
A Horizontal Magnetic Tweezers for Studying Single DNA Molecules and DNA-Binding Proteins
Molecules, 2021 We report data from single molecule studies on the interaction between single DNA molecules and core histones using custom-designed horizontal magnetic tweezers.
Roberto Fabian +5 more
doaj +1 more source
Circulating nucleosomes as new blood-based biomarkers for detection of colorectal cancer
Clinical Epigenetics, 2017 BackgroundColonoscopy is currently widely accepted as the gold standard for detection of colorectal cancer (CRC) providing detection of up to 95% of pre-cancerous lesions during the procedure.
J. Rahier +12 more
semanticscholar +1 more source
Liquid biopsy epigenetics: establishing a molecular profile based on cell‐free DNA
Molecular Oncology, EarlyView.Cell‐free DNA (cfDNA) fragments in plasma from cancer patients carry epigenetic signatures reflecting their cells of origin. These epigenetic features include DNA methylation, nucleosome modifications, and variations in fragmentation. This review describes the biological properties of each feature and explores optimal strategies for harnessing cfDNA ...
Christoffer Trier Maansson +2 more
wiley +1 more source
Revista Brasileira de Reumatologia, 2012 OBJETIVOS: Determinar a frequência de anticorpos contra componentes da cromatina no lúpus eritematoso sistêmico juvenil (LESJ) e correlacionar a presença desses autoanticorpos com manifestações clínicas e atividade da doença.
Silene Peres Keusseyan +5 more
doaj +1 more source