Results 61 to 70 of about 71,049 (222)
Tension-dependent Free Energies of Nucleosome Unwrapping [PDF]
, 2016 Nucleosomes form the basic unit of compaction within eukaryotic genomes and their locations represent an important, yet poorly understood, mechanism of genetic regulation. Quantifying the strength of interactions within the nucleosome is a central problem in biophysics and is critical to understanding how nucleosome positions influence gene expression.
arxiv +1 more source
Intra-Chromosomal Potentials from Nucleosomal Positioning Data [PDF]
arXiv, 2021 No systematic method exists to derive intra-chromosomal potentials between nucleosomes along a chromosome consistently across a given genome. Such potentials can yield information on nucleosomal ordering, thermal as well as mechanical properties of chromosomes.
arxiv
Nucleosome positioning: resources and tools online [PDF]
Briefings in Bioinformatics (2016) 17, 745-757, 2015 Nucleosome positioning is an important process required for proper genome packing and its accessibility to execute the genetic program in a cell-specific, timely manner. In the recent years hundreds of papers have been devoted to the bioinformatics, physics and biology of nucleosome positioning. The purpose of this review is to cover a practical aspect
arxiv +1 more source
Circulating nucleosomes as new blood-based biomarkers for detection of colorectal cancer
Clinical Epigenetics, 2017 BackgroundColonoscopy is currently widely accepted as the gold standard for detection of colorectal cancer (CRC) providing detection of up to 95% of pre-cancerous lesions during the procedure.
J. Rahier +12 more
semanticscholar +1 more source
CENP-A and H3 Nucleosomes Display a Similar Stability to Force-Mediated Disassembly. [PDF]
PLoS ONE, 2016 Centromere-specific nucleosomes are a central feature of the kinetochore complex during mitosis, in which microtubules exert pulling and pushing forces upon the centromere. CENP-A nucleosomes have been assumed to be structurally unique, thereby providing
Sung Hyun Kim +4 more
doaj +1 more source
Exploring the Free Energy Landscape of Nucleosomes.
Journal of the American Chemical Society, 2016 The nucleosome is the fundamental unit for packaging the genome. A detailed molecular picture for its conformational dynamics is crucial for understanding transcription and gene regulation.
Bin Zhang +3 more
semanticscholar +1 more source
Statistical Mechanics of Nucleosomes Constrained by Higher-Order Chromatin Structure [PDF]
, 2010 Eukaryotic DNA is packaged into chromatin: one-dimensional arrays of nucleosomes separated by stretches of linker DNA are folded into 30-nm chromatin fibers which in turn form higher-order structures. Each nucleosome, the fundamental unit of chromatin, has 147 base pairs of DNA wrapped around a histone octamer.
arxiv +1 more source
Nucleosomes influence multiple steps during replication initiation
eLife, 2017 Eukaryotic replication origin licensing, activation and timing are influenced by chromatin but a mechanistic understanding is lacking. Using reconstituted nucleosomal DNA replication assays, we assessed the impact of nucleosomes on replication initiation.
Ishara F Azmi +7 more
semanticscholar +1 more source
A quantitative investigation of linker histone interactions with nucleosomes and chromatin
Scientific Reports, 2016 Linker histones such as H1 are abundant basic proteins that bind tightly to nucleosomes, thereby acting as key organizers of chromatin structure. The molecular details of linker histone interactions with the nucleosome and in particular the contributions
Alison E. White, Aaron R Hieb, K. Luger
semanticscholar +1 more source
Abstract OR-19: Integrative Approach on Nucleosome Complexes Modeling [PDF]
International Journal of Biomedicine, 2019 Background: Nucleosomes are the key structural elements of chromatin in all higher organisms. While X-ray crystallography studies of nucleosomes have consistently yielded similar atomistic structures, many biophysical and biochemical techniques suggest ...
Grigoriy A. Armeev +2 more
doaj +1 more source