Results 61 to 70 of about 69,179 (216)
Biotechnology and Applied Biochemistry, EarlyView.ABSTRACT Background: This study aims to identify genes with a high likelihood of genetic variation, significant expression differences, and prognostic implications in colorectal cancer (CRC) patients. The research also seeks to investigate the role and mechanisms of key genes in CRC through the analysis of health information data and a combination of ...
Kaobin Ouyang +3 more
wiley +1 more source
TRF1 and TRF2 binding to telomeres is modulated by nucleosomal organization [PDF]
, 2015 The ends of eukaryotic chromosomes need to be protected from the activation of a DNA damage response that leads the cell to replicative senescence or apoptosis.
Alicata, Claudia +8 more
core +2 more sources
MYC: The Guardian of Its Own Chaos
BioEssays, EarlyView.MYC is an oncogene that drives tumorigenesis through enhanced transcription and replication. Paradoxically, MYC induces transcriptional and replicative stress and acts as a resilience factor against these stressors. We discuss how MYC balances these stressors to promote tumor growth while evading immune detection and propose strategies to target MYC ...
Abdallah Gaballa +2 more
wiley +1 more source
Ubiquitous nucleosome unwrapping in the yeast genome [PDF]
, 2013 Nucleosome core particle is a dynamic structure -- DNA may transiently peel off the histone octamer surface due to thermal fluctuations or the action of chromatin remodeling enzymes.
Chereji, Răzvan V. +1 more
core +2 more sources
The Link Between TGF‐β Signaling and Chromatin Dynamics Takes an Unexpected Path
BioEssays, EarlyView.A recent study uncovered a novel mechanism by which Tgfbr1 regulates morphogenesis: not by directly controlling the expression of genes regulating cell fate but by globally modulating chromatin accessibility, thus determining which enhancers are available to other morphogenetic factors, ultimately enabling the activation of specific developmental ...
Moises Mallo
wiley +1 more source
Probing the (H3-H4)(2) histone tetramer structure using pulsed EPR spectroscopy combined with site-directed spin labelling [PDF]
, 2009 The (H3-H4)2 histone tetramer forms the central core of nucleosomes and, as such, plays a prominent role in assembly, disassembly and positioning of nucleosomes.
Bowman, A. +4 more
core +4 more sources
Compact Origins and Where to Find Them: ORC's Guide to Genome‐Wide Licensing
BioEssays, EarlyView.Origin licensing is a key requirement for any eukaryotic cell to initiate DNA replication in S‐phase. Here, we review the most recent findings in the orchestrated action of the origin recognition complex (ORC) to sequentially load two MCM2‐7 helicases onto DNA with a focus on origin architecture and sequencing‐based methods.
Christian Speck +1 more
wiley +1 more source
Identification of H3K4me1-associated proteins at mammalian enhancers. [PDF]
, 2017 Enhancers act to regulate cell-type-specific gene expression by facilitating the transcription of target genes. In mammalian cells, active or primed enhancers are commonly marked by monomethylation of histone H3 at lysine 4 (H3K4me1) in a cell-type ...
Albuquerque, Claudio P +13 more
core +2 more sources
Biotechnology Progress, EarlyView.Abstract Recombinant adeno‐associated virus (rAAV) is a widely used delivery vehicle in gene therapy. A scalable production technology is essential for its wide clinical applications. We have taken a synthetic biology approach to generate HEK293‐based cell lines which harbor integrated genetic elements encoding essential AAV and adenoviral helper ...
Han‐Jung Kuo +6 more
wiley +1 more source
Advances in Isotope Labeling for Solution Nucleic Acid Nuclear Magnetic Resonance Spectroscopy
ChemPlusChem, EarlyView.Recent advances in the field of nucleic acid nuclear magnetic resonance (NMR) are presented. Stable isotope labeling protocols and new approaches to segmentally label nucleic acid with NMR‐active residues are summarized. The novel methods will have a strong impact on the future of nucleic acid NMR and the characterization of structure and dynamics of ...
Stefan Hilber +3 more
wiley +1 more source