Results 81 to 90 of about 71,049 (222)
Theory of Nucleosome Corkscrew Sliding in the Presence of Synthetic DNA Ligands [PDF]
arXiv, 2004 Histone octamers show a heat-induced mobility along DNA. Recent theoretical studies have established two mechanisms that are qualitatively and quantitatively compatible with in vitro experiments on nucleosome sliding: Octamer repositiong through one-basepair twist defects and through ten-basepair bulge defects. A recent experiment demonstrated that the
arxiv
Asymmetric nucleosomes flank promoters in the budding yeast genome
Genome Research, 2015 Nucleosomes in active chromatin are dynamic, but whether they have distinct structural conformations is unknown. To identify nucleosomes with alternative structures genome-wide, we used H4S47C-anchored cleavage mapping, which revealed that 5% of budding ...
S. Ramachandran, G. Zentner, S. Henikoff
semanticscholar +1 more source
Molecular Dynamics Simulations of a Nucleosome and Free DNA [PDF]
arXiv, 2004 Nucleosomes organize the folding of DNA into chromatin and significantly influence transcription, replication, regulation and repair. All atom molecular dynamics simulations of a nucleosome and of its 146 basepairs of DNA free in solution have been conducted.
arxiv
Epigenetics & Chromatin, 2015 BackgroundThe histone H3 variant CENP-A is normally tightly regulated to ensure only one centromere exists per chromosome. Native CENP-A is often found overexpressed in human cancer cells and a range of human tumors. Consequently, CENP-A misregulation is
Rajbir K Athwal +8 more
semanticscholar +1 more source
eLife, 2018 VivosX is an in vivo disulfide crosslinking approach that utilizes a pair of strategically positioned cysteines on two proteins to probe physical interactions within cells.
Chitra Mohan +6 more
doaj +1 more source
Affinity, stoichiometry and cooperativity of heterochromatin protein 1 (HP1) binding to nucleosomal arrays [PDF]
, 2014 Heterochromatin protein 1 (HP1) participates in establishing and maintaining heterochromatin via its histone modification dependent chromatin interactions. In recent papers HP1 binding to nucleosomal arrays was measured in vitro and interpreted in terms of nearest-neighbor cooperative binding. This mode of chromatin interactions could lead to spreading
arxiv +1 more source
Circulating nucleosomes as epigenetic biomarkers in pancreatic cancer
Clinical Epigenetics, 2015 BackgroundTo improve the prognosis of patients with pancreatic cancer, new biomarkers are required for earlier, pre-symptomatic diagnosis. Epigenetic mutations take place at the earliest stages of tumorigenesis and therefore offer new approaches for ...
Monika Bauden +7 more
semanticscholar +1 more source
Science Advances, 2015 Reestablishment of the nucleosome landscape behind the replication fork is fundamental for epigenetic memory during development. Eukaryotic replication disrupts each nucleosome as the fork passes, followed by reassembly of disrupted nucleosomes and ...
S. Ramachandran, S. Henikoff
semanticscholar +1 more source
Nucleosome positioning and energetics: Recent advances in genomic and computational studies [PDF]
Advances in Protein Chemistry and Structural Biology, Volume 79
(2010) Pages 1-57, 2009 Chromatin is a complex of DNA, RNA and proteins whose primary function is to package genomic DNA into the tight confines of a cell nucleus. A fundamental repeating unit of chromatin is the nucleosome, an octamer of histone proteins around which 147 base pairs of DNA are wound in almost two turns of a left-handed superhelix.
arxiv
mBioIsw2 proteins, ubiquitous across eukaryotes, exhibit a propensity for DNA binding and exert dynamic influences on local chromosome condensation in an ATP-dependent fashion, thereby modulating the accessibility of neighboring genes to transcriptional ...
Mengtian Pei +8 more
doaj +1 more source