Results 81 to 90 of about 72,215 (324)
Advanced Science, EarlyView.This study integrates dual‐reporter genetics, imaging flow cytometry, and single‐cell sequencing to characterize rare bihormonal cells in mouse and human pancreatic islets. Gcg⁺Ins⁺ cells resemble α‐cells rather than transitional states. Cross‐species gene network analysis refines islet cell taxonomy and reveals human‐specific δ‐cell subtypes ...
Xin‐Xin Yu +10 more
wiley +1 more source
The Nucleosome Remodeling Factor [PDF]
FEBS Letters, 2011 An essential component of the chromatin remodeling machinery is NURF (Nucleosome Remodeling Factor), the founding member of the ISWI family of chromatin remodeling complexes. In vertebrates and invertebrates alike, NURF has many important functions in chromatin biology including regulating transcription, establishing boundary elements, and promoting ...
Joseph W. Landry, Suehyb G. Alkhatib
openaire +3 more sources
Genomic Variation Underpins Genetic Divergence and Differing Salt Resilience in Sesbania bispinosa
Advanced Science, EarlyView.Sesbania, a leguminous halophyte, thrives in saline soils. Comparative genomics reveals key genomic variations—particularly chromosomal inversions—are identified as contributors to population differentiation and salt resilience. These findings advance the understanding of genomic variation driving evolution and phenotypic differentiation and offer ...
Gai Huang +13 more
wiley +1 more source
Ctf4 organizes sister replisomes and Pol α into a replication factory
eLife, 2019 The current view is that eukaryotic replisomes are independent. Here we show that Ctf4 tightly dimerizes CMG helicase, with an extensive interface involving Psf2, Cdc45, and Sld5. Interestingly, Ctf4 binds only one Pol α-primase.
Zuanning Yuan +8 more
doaj +1 more source
A quantitative investigation of linker histone interactions with nucleosomes and chromatin
Scientific Reports, 2016 Linker histones such as H1 are abundant basic proteins that bind tightly to nucleosomes, thereby acting as key organizers of chromatin structure. The molecular details of linker histone interactions with the nucleosome and in particular the contributions
Alison E. White, Aaron R Hieb, K. Luger
semanticscholar +1 more source
Nucleosome Positioning with Set of Key Positions and Nucleosome Affinity [PDF]
The Open Biomedical Engineering Journal, 2014 The formation and precise positioning of nucleosome in chromatin occupies a very important role in studying life process. Today, there are many researchers who discovered that the positioning where the location of a DNA sequence fragment wraps around a histone octamer in genome is not random but regular.
Jia Wang, Shuai Liu, Weina Fu
openaire +3 more sources
Advanced Science, EarlyView.Immuno‐lung organoids are developed and used spatial transcriptomics to uncover how proinflammatory macrophages drive lung cell senescence via the THBS1–(ITGA3+ITGB1) axis in COVID‐19. To ensure broad accessibility, LungSpatialDB is created, an AI‐powered data portal, enabling intuitive exploration of spatial data and biological insights through ...
Yuling Han +24 more
wiley +1 more source
Fine Chromatin-Driven Mechanism of Transcription Interference by Antisense Noncoding Transcription
Cell Reports, 2020 Summary: Eukaryotic genomes are almost entirely transcribed by RNA polymerase II. Consequently, the transcription of long noncoding RNAs often overlaps with coding gene promoters, triggering potential gene repression through a poorly characterized ...
Jatinder Kaur Gill +4 more
doaj
LPS-Challenged Macrophages Release Microvesicles Coated With Histones
Frontiers in Immunology, 2018 Histones are the protein component of nucleosomes, which are the basic packing unit of chromatin. However, histones are also found in the blood, both as components of nucleosomes leaked out from dead cells, or expelled from neutrophils in the active ...
Rohini Ravindran Nair +5 more
doaj +1 more source
H2A.Z controls the stability and mobility of nucleosomes to regulate expression of the LH genes
Nature Communications, 2016 The structure and dynamics of promoter chromatin have a profound effect on the expression levels of genes. Yet, the contribution of DNA sequence, histone post-translational modifications, histone variant usage and other factors in shaping the ...
Sergei Rudnizky +5 more
semanticscholar +1 more source