Results 1 to 10 of about 621,729 (284)

Metabolic reprogramming by pseudorabies virus: nucleotide metabolism as a central vulnerability for viral replication and pathogenesis [PDF]

Frontiers in Microbiology
Pseudorabies virus (PRV), a neurotropic alphaherpesvirus, causes severe neurological and reproductive disorders in swine, posing substantial threats to the global swine industry and emerging as a zoonotic concern.
Xiaoyong Chen, Qingsen Wang, Xi Chen
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Thymidine phosphorylase in nucleotide metabolism: physiological functions and its implications in tumorigenesis and anti-cancer therapy [PDF]

Frontiers in Immunology
Thymidine phosphorylase (TYMP), a protein found in both prokaryotic and eukaryotic cells, is encoded by a gene located in the q13 region of chromosome 22. With a relative molecular mass of 55,000, TYMP exists as a homodimer.
Bo Huang, Bo Huang, Qihang Yuan, Jiaao Sun, Chao Wang, Dong Yang   +5 more
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Spatial transcriptome and single-cell sequencing reveal the role of nucleotide metabolism in breast cancer progression and tumor microenvironment [PDF]

Frontiers in Oncology
BackgroundThe complexities of nucleotide metabolism in breast cancer (BC) cells are not yet fully understood. A deeper exploration of the various tumor subpopulations and their interactions with the tumor microenvironment (TME) could provide important ...
Yuejun Pan, Yong Xu, Ke Gong, Songlin Yuan   +3 more
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Roles of nucleotide metabolism in pancreatic cancer [PDF]

Frontiers in Immunology
Nucleotide metabolism plays a pivotal role in the onset and progression of various human diseases, including pancreatic disorders. As fundamental biomolecules, nucleotides are essential for DNA and RNA synthesis, energy production, and cell signaling ...
Quanlin Liu, Jiahua Liu, Shige Wang, Nabuqi Bao, Xinya Zhao, Lei Wang   +5 more
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Integrated bioinformatics analysis of nucleotide metabolism based molecular subtyping and biomarkers in lung adenocarcinoma [PDF]

Frontiers in Immunology
BackgroundLung adenocarcinoma (LUAD), a predominant subtype of non-small cell lung cancers, continues to challenge treatment outcomes due to its heterogeneity and complex tumor microenvironment (TME).
Dayuan Luo, Dayuan Luo, Haohui Wang, Haohui Wang, Zhen Zeng, Zhen Zeng, Jiajing Chen, Jiajing Chen, Haiqin Wang, Haiqin Wang   +9 more
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Identification of Key Nucleotide Metabolism Genes in Diabetic Retinopathy Based on Bioinformatics Analysis and Experimental Verification [PDF]

Biology
A dysregulated nucleotide metabolism has been implicated in the pathogenesis of diabetic retinopathy (DR). RNA sequencing datasets, GSE102485, GSE60436, and GSE165784, were downloaded from the GEO database.
Wei Wang, Jianyang Gong
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Increased nucleotide metabolism alleviates Alzheimer’s disease pathology [PDF]

Cell Death and Disease
Genetic information in cells flows from DNA to RNA to proteins, which form molecular machines. During normal ageing, cell intrinsic and environmental factors alter this flow of information by damaging DNA in cells, including postmitotic neurons.
Yizhou Yu, Michael B. Miller, August Yue Huang, Bryan Wei Zhi Tan, Ivana Celardo, Nuno Santos Leal, Samantha H. Y. Loh, L. Miguel Martins   +7 more
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Integration of single-cell transcriptomics and bulk transcriptomics to explore prognostic and immunotherapeutic characteristics of nucleotide metabolism in lung adenocarcinoma [PDF]

Frontiers in Genetics
BackgroundLung adenocarcinoma (LUAD) is a highly aggressive tumor with one of the highest morbidity and mortality rates in the world. Nucleotide metabolic processes are critical for cancer development, progression, and alteration of the tumor ...
Kai Zhang, Kai Zhang, Luyao Wang, Huili Chen, Lili Deng, Mengling Hu, Ziqiang Wang, Yiluo Xie, Chaoqun Lian, Xiaojing Wang, Xiaojing Wang, Jing Zhang   +11 more
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Nucleotide Metabolism and Immune Genes Can Predict the Prognostic Risk of Hepatocellular Carcinoma and the Immune Microenvironment [PDF]

Biology
The overall survival of hepatocellular carcinoma (HCC) remains poor, highlighting the need for better prognostic tools. Nucleotide metabolism fuels tumor progression, while the immune microenvironment dictates therapy response, but integrated models ...
Xiaofang Wang, Qinghua Cui, Yuan Zhou
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Transcriptional regulation of nucleotide metabolism in medulloblastoma subtypes and prognostic implications analyzed by RNA-Seq [PDF]

Journal of Cancer Research and Clinical Oncology
Objective Subtypes of medulloblastoma (MB), WNT, SHH, Group 3 and Group 4, have different prognoses and the impact of abnormal nucleotide metabolism remains unclear.
Rong Huang, Xiaoxu Lu, Xueming Sun, Hui Wu   +3 more
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