Results 21 to 30 of about 621,729 (284)

Metabolic Promiscuity of an Orphan Small Alarmone Hydrolase Facilitates Bacterial Environmental Adaptation

mBio, 2022
Small alarmone hydrolases (SAHs) are alarmone metabolizing enzymes found in both metazoans and bacteria. In metazoans, the SAH homolog Mesh1 is reported to function in cofactor metabolism by hydrolyzing NADPH to NADH.
Danny K. Fung, Kaihong Bai, Jin Yang, Xiaoli Xu, David M. Stevenson, Daniel Amador-Noguez, Laixin Luo, Jue D. Wang   +7 more
doaj   +1 more source

IGFBP2 from a novel copper metabolism-associated biomarker promoted glioma progression and response to immunotherapy

Frontiers in Immunology, 2023
IntroductionCopper metabolism encompasses all cellular metabolic processes involving copper ions and plays a significant role in the pathogenesis of diseases, including cancer.
Qisheng Luo, Junhong Zhuang, Dandan Zheng, Changfeng Miao, Hongcheng Luo, Jun Peng, Chuanhua Zheng, Chengjian Qin, Chuanliu Lan, Meiqin Chen, Ying Xia, Deyou Huang, Zigui Chen   +12 more
doaj   +1 more source

Matrine, a potential c-Myc inhibitor, suppresses ribosome biogenesis and nucleotide metabolism in myeloid leukemia

Frontiers in Pharmacology, 2022
Previous studies have shown that matrine, a natural compound extracted from the herb Sophora flavescens, has a good anti-leukemia effect, but its key target and mechanism remains unclear.
Wang-Jing Zhong, Lingdi Ma, Lingdi Ma, Fanfan Yang, Jialin Cao, Junyu Tan, Bohong Li   +6 more
doaj   +1 more source

Correction: Thymidine phosphorylase in nucleotide metabolism: physiological functions and its implications in tumorigenesis and anti-cancer therapy [PDF]

Frontiers in Immunology
Bo Huang, Bo Huang, Qihang Yuan, Jiaao Sun, Chao Wang, Dong Yang   +5 more
doaj   +2 more sources

A Nucleotide Metabolism-Related Gene Signature for Risk Stratification and Prognosis Prediction in Hepatocellular Carcinoma Based on an Integrated Transcriptomics and Metabolomics Approach

Metabolites, 2023
Hepatocellular carcinoma (HCC) is a leading cause of cancer-related mortality worldwide. The in-depth study of genes and metabolites related to nucleotide metabolism will provide new ideas for predicting the prognosis of HCC patients.
Tianfu Wei, Jifeng Liu, Shurong Ma, Mimi Wang, Qihang Yuan, Anliang Huang, Zeming Wu, Dong Shang, Peiyuan Yin   +8 more
doaj   +1 more source

Epstein-Barr Virus Induced Cytidine Metabolism Roles in Transformed B-Cell Growth and Survival

mBio, 2021
Epstein-Barr virus (EBV) is associated with 200,000 cancers annually, including B-cell lymphomas in immunosuppressed hosts. Hypomorphic mutations of the de novo pyrimidine synthesis pathway enzyme cytidine 5′ triphosphate synthase 1 (CTPS1) suppress cell-
Jin Hua Liang, Chong Wang, Stephanie Pei Tung Yiu, Bo Zhao, Rui Guo, Benjamin E. Gewurz   +5 more
doaj   +1 more source

Asparagine promotes cancer cell proliferation through use as an amino acid exchange factor. [PDF]

, 2016
Cellular amino acid uptake is critical for mTOR complex 1 (mTORC1) activation and cell proliferation. However, the regulation of amino acid uptake is not well-understood.
Braas, Daniel, Christofk, Heather R, Graeber, Thomas G, Krall, Abigail S, Xu, Shili   +4 more
core   +1 more source

Whole Genome Analysis of the Red-Crowned Crane Provides Insight into Avian Longevity [PDF]

, 2020
The red-crowned crane (Grus japonensis) is an endangered, large-bodied crane native to East Asia. It is a traditional symbol of longevity and its long lifespan has been confirmed both in captivity and in the wild.
Bhak, Jong, Blazyte, Asta, Cho, Yun Sung, Choi, Jae-Pil, Chung, Oksung, Edwards, Jeremy S., Jeon, Sungwon, Jho, Sungwoong, Jun, JeHoon, Kim, Hak-Min, Kim, Jungeun, Lee, HyeJin, Lim, Jeongheui, Paek, Woon Kee, Weber, Jessica A.   +14 more
core   +1 more source

Nanomaterials for cancer therapy: current progress and perspectives

Journal of Hematology & Oncology, 2021
Cancer is a disease with complex pathological process. Current chemotherapy faces problems such as lack of specificity, cytotoxicity, induction of multi-drug resistance and stem-like cells growth.
Zhe Cheng, Maoyu Li, Raja Dey, Yongheng Chen   +3 more
doaj   +1 more source

One-carbon metabolism in cancer [PDF]

, 2017
Cells require one-carbon units for nucleotide synthesis, methylation and reductive metabolism, and these pathways support the high proliferative rate of cancer cells.
AJ MacFarlane, Alice C Newman, AS Tibbetts, B Chaneton, BC Blount, C Commisso, CA Lewis, CF Labuschagne, CF Woeller, D Hanahan, D Hanahan, D Kim, DD Anderson, E Currie, E Mullarky, F Daidone, F Kottakis, G Kikuchi, GM DeNicola, Gregory S. Ducker, GS Ducker, J Liu, J Meiser, J Ye, Jason W. Locasale, JJ Kamphorst, JW Locasale, K Snell, K Snell, K Snell, Katherine R. Mattaini, L Galluzzi, M Goulian, M Jain, M Kulis, Mahya Mehrmohamadi, ME Pacold, Ming Yang, MJ Osborn, ML Rose, ML Rose, OD Maddocks, OD Maddocks, Oliver D K Maddocks, Oliver D. K. Maddocks, PM Ueland, R Possemato, S Farber, S Kit, S Pollari, SJ Mentch, Swetha Bolusani, T Shlomi, WC Zhang, Y Fu, Z Ser   +55 more
core   +1 more source