Results 101 to 110 of about 566,734 (334)

Ventral hippocampal afferents to the nucleus accumbens regulate susceptibility to depression

Nature Communications, 2015
Enhanced glutamatergic transmission in the nucleus accumbens (NAc), a region critical for reward and motivation, has been implicated in the pathophysiology of depression; however, the afferent source of this increased glutamate tone is not known. The NAc
R. Bagot, E. Parise, C. Peña, Hong-Xing Zhang, I. Maze, D. Chaudhury, Brianna Persaud, R. Cachope, Carlos A. Bolaños-Guzmán, J. Cheer, K. Deisseroth, Ming-Hu Han, E. Nestler   +12 more
semanticscholar   +1 more source

Perimovement decrease of alpha/beta oscillations in the human nucleus accumbens [PDF]

, 2016
The human nucleus accumbens is thought to play an important role in guiding future action selection via an evaluation of current action outcomes.
Dolan, RJ, Duerschmid, S, Heinze, H-J, Kaufmann, J, Rutledge, RB, Schmitt, FC, Schoenfeld, MA, Stenner, M-P, Voges, J, Zaehle, T   +9 more
core   +1 more source

Cholinergic System Changes in Dopa‐Unresponsive Freezing of Gait in Parkinson's Disease

Movement Disorders, EarlyView.
Abstract Background Freezing of gait (FoG) is a debilitating mobility disturbance that becomes increasingly resistant to dopaminergic pharmacotherapies with advancing Parkinson's disease (PD). The pathophysiology underlying the response of FoG to dopaminergic treatment is poorly understood.
Kelvin L. Chou, Prabesh Kanel, Miriam van Emde Boas, Stiven Roytman, Giulia Carli, Roger L. Albin, Nicolaas I. Bohnen   +6 more
wiley   +1 more source

Decreased Nucleus Accumbens Expression of Psychiatric Disorder Risk Gene Cacna1c Promotes Susceptibility to Social Stress

International Journal of Neuropsychopharmacology, 2017
Background: Polymorphisms in the CACNA1C gene are associated with human mood disorders. The rodent social defeat model of stress/mood-disorder susceptibility results in maladaptive consequences mediated by altered function of mesolimbic circuits. Methods:
C. Terrillion, T. C. Francis, A. Puche, M. Lobo, T. Gould   +4 more
semanticscholar   +1 more source

Food-induced behavioral sensitization, its cross-sensitization to cocaine and morphine, pharmacological blockade, and effect on food intake [PDF]

, 2006
Repeated administration of abused drugs sensitizes their stimulant effects and results in a drug-paired environment eliciting conditioned activity. We tested whether food induces similar effects.
Le Merrer, Julie, Stephens, David N
core   +1 more source

Early‐Onset Movement Disorder Syndrome Caused by Biallelic Variants in PDE1B Encoding Phosphodiesterase 1B

Movement Disorders, EarlyView.
Abstract Background Breakdown of cyclic adenosine monophosphate (cAMP) and cyclic guanosine monophosphate (cGMP) in basal ganglia cells through hydrolysis of diesteric bonds, primarily by PDE10A and PDE1B, is essential for normal human movement. While biallelic loss‐of‐function variants in PDE10A are known to cause hyperkinetic movement disorders, the ...
Tomer Poleg, Noam Hadar, Eyal Kristal, Nicola Y. Roberts, Vadim Dolgin, Ilana Aminov, Amit Safran, Nadav Agam, Matan Jean, Ofek Freund, Eamonn G. Sheridan, James A. Poulter, Michelle L. Thompson, Yusra Algoos, Salma Al‐Qahtani, Lama AlAbdi, Sateesh Maddirevula, Verity Hartill, Henry Houlden, Reza Maroofian, Amit Nahum, Ohad S. Birk   +21 more
wiley   +1 more source

Lithium treatment impacts nucleus accumbens shape in bipolar disorder

NeuroImage: Clinical, 2020
The effects of lithium treatment duration on deep grey matter structures in bipolar disorder are not well known. In this cross-sectional neuroimaging case-control study, we tested the hypothesis that shape characteristics of deep grey matter structures ...
Daniela Vecchio, Fabrizio Piras, Federica Piras, Nerisa Banaj, Delfina Janiri, Alessio Simonetti, Gabriele Sani, Gianfranco Spalletta   +7 more
doaj  

Drug-Induced Plasticity Contributing to Heightened Relapse Susceptibility: Neurochemical Changes and Augmented Reinstatement in High-Intake Rats [PDF]

, 2010
A key in understanding the neurobiology of addiction and developing effective pharmacotherapies is revealing drug-induced plasticity that results in heightened relapse susceptibility.
Baker, David A., Kau, Kristen S., Lobner, Doug, Madayag, Aric, Mantsch, John R., Wisniewski, Samantha   +5 more
core   +1 more source

Corticostriatal plasticity in the nucleus accumbens core

Journal of Neuroscience Research, 2019
AbstractSmall fluctuations in striatal glutamate and dopamine are required to establish goal‐directed behaviors and motor learning, while large changes appear to underlie many neuropsychological disorders, including drug dependence and Parkinson's disease.
Wengang Wang, Wengang Wang, Nigel S. Bamford   +2 more
openaire   +4 more sources

Recent Developments in the Optical Control of Adrenergic Signaling

Medicinal Research Reviews, EarlyView.
ABSTRACT Adrenoceptors (ARs) play a vital role in various physiological processes and are key therapeutic targets. The advent of optical control techniques, including optogenetics and photopharmacology, offers the potential to modulate AR signaling with precise temporal and spatial resolution. In this review, we summarize the latest advancements in the
Shuang Shi, Yangzhi Cao, Maikel Wijtmans, Henry F. Vischer, Rob Leurs   +4 more
wiley   +1 more source