Results 111 to 120 of about 566,734 (334)

Dopamine, behavioral economics, and effort

Frontiers in Behavioral Neuroscience, 2009
. There are numerous problems with the hypothesis that brain dopamine (DA) systems, particularly in the nucleus accumbens, directly mediate the rewarding or primary motivational characteristics of natural stimuli such as food.
John D Salamone, Merce Correa, Andrew M Farrar, Eric J Nunes, Marta Pardo   +4 more
doaj   +1 more source

Decoding molecular and cellular heterogeneity of mouse nucleus accumbens

Nature Neuroscience, 2021
Renchao Chen, Timothy R Blosser, M. N. Djekidel, Junjie Hao, A. Bhattacherjee, Wenqiang Chen, L. Tuesta, X. Zhuang, Yi Zhang   +8 more
semanticscholar   +1 more source

Repeated \u3cem\u3eN\u3c/em\u3e-Acetylcysteine Administration Alters Plasticity-Dependent Effects of Cocaine [PDF]

, 2007
Cocaine produces a persistent reduction in cystine–glutamate exchange via system xc− in the nucleus accumbens that may contribute to pathological glutamate signaling linked to addiction.
Abdulhameed, Omer, Baker, David A., Grier, Mark D., Hearing, Matthew, Kau, Kristen S., Lobner, Doug, Madayag, Aric, Mantsch, John R.   +7 more
core   +1 more source

Dnmt3a regulates emotional behavior and spine plasticity in the nucleus accumbens. [PDF]

, 2010
Despite abundant expression of DNA methyltransferases (Dnmts) in brain, the regulation and behavioral role of DNA methylation remain poorly understood. We found that Dnmt3a expression was regulated in mouse nucleus accumbens (NAc) by chronic cocaine use ...
Bolaños, Carlos A, Covington, Herbert E, Dietz, David M, Dumitriu, Dani, Eisch, Amelia J, Fan, Gouping, Feng, Jian, Hollis, Fiona, Hurd, Yasmin L, Iñiguez, Sergio D, Kabbaj, Mohamed, Koo, Ja Wook, LaPlant, Quincey, Maze, Ian, Morrison, John H, Mouzon, Ezekiell, Nestler, Eric J, Neve, Rachael L, Noonan, Michele A, Oosting, Ronald S, Ren, Yanhua, Renthal, William, Vialou, Vincent, Wang, Hui, Warren, Brandon L, Watts, Emily L, Xiao, Guanghua   +26 more
core   +3 more sources

Molecular Tools to Study and Control Dopaminergic Neurotransmission With Light

Medicinal Research Reviews, EarlyView.
ABSTRACT Dopaminergic neurotransmission is involved in several important brain functions, such as motor control, learning, reward‐motivated behavior, and emotions. Dysfunctions of dopaminergic system may lead to the development of various neurological and psychiatric disorders, like Parkinson's disease, schizophrenia, depression, and addictions ...
Galyna Maleeva, Carlo Matera, Silvia Roda, Alessio Colleoni, Marco De Amici, Pau Gorostiza   +5 more
wiley   +1 more source

Active Avoidance Requires a Serial Basal Amygdala to Nucleus Accumbens Shell Circuit

Journal of Neuroscience, 2015
Freezing is a species-typical defensive reaction to conditioned threats. While the neural circuitry of aversive Pavlovian behavior has been extensively studied, less is known about the circuitry underlying more active responses to danger.
Franchesca Ramirez, Justin M. Moscarello, Joseph E LeDoux, Robert M Sears   +3 more
semanticscholar   +1 more source

Targeting Histone H3K9 Methyltransferase G9a as a Potential Therapeutic Strategy for Neuropsychiatric Disorders

Medicinal Research Reviews, EarlyView.
ABSTRACT Neuropsychiatric disorders present a multifaceted challenge, characterized by cognitive, social, and motor impairments with manifold underlying mechanisms. Recent attention has turned to epigenetic mechanisms, particularly histone lysine methyltransferases (HKMTs), such as G9a, in understanding fundamental pathogenesis.
Malak Hajar, Tobias Werner, Mihajlo Gajic, Holger Stark, Bassem Sadek   +4 more
wiley   +1 more source

Accumbal-thalamic connectivity and associated glutamate alterations in human cocaine craving: A state-dependent rs-fMRI and 1H-MRS study

NeuroImage: Clinical, 2023
Craving is a core symptom of cocaine use disorder and a major factor for relapse risk. To date, there is no pharmacological therapy to treat this disease or at least to alleviate cocaine craving as a core symptom.
Etna J.E. Engeli, Andrea G. Russo, Sara Ponticorvo, Niklaus Zoelch, Andreas Hock, Lea M. Hulka, Matthias Kirschner, Katrin H. Preller, Erich Seifritz, Boris B. Quednow, Fabrizio Esposito, Marcus Herdener   +11 more
doaj  

Supersensitive Kappa Opioid Receptors Promotes Ethanol Withdrawal-Related Behaviors and Reduce Dopamine Signaling in the Nucleus Accumbens

International Journal of Neuropsychopharmacology, 2015
Background: Chronic ethanol exposure reduces dopamine transmission in the nucleus accumbens, which may contribute to the negative affective symptoms associated with ethanol withdrawal.
J. Rose, Anushree N. Karkhanis, Rong Chen, D. Gioia, Marcelo F. Lopez, H. Becker, B. McCool, S. Jones   +7 more
semanticscholar   +1 more source

The challenge hypothesis revisited: Focus on reproductive experience and neural mechanisms. [PDF]

, 2020
Our review focuses on findings from mammals as part of a Special Issue "30th Anniversary of the Challenge Hypothesis". Here we put forth an integration of the mechanisms through which testosterone controls territorial behavior and consider how ...
Marler, Catherine A, Trainor, Brian C
core   +1 more source