Results 121 to 130 of about 566,734 (334)

Corticosterone Regulates Both Naturally Occurring and Cocaine‐Induced Dopamine Signaling by Selectively Decreasing Dopamine Uptake [PDF]

, 2017
Stressful and aversive events promote maladaptive reward‐seeking behaviors such as drug addiction by acting, in part, on the mesolimbic dopamine system. Using animal models, data from our laboratory and others show that stress and cocaine can interact to
Baker, David A., Bohn, Austin T., Ebben, Amanda L., Gasser, Paul J., Jasek, Isabella A., Kurtoglu, Beliz, Lovell, Marissa E., Mantsch, John R., Wheeler, Daniel S., Wheeler, Robert A.   +9 more
core   +2 more sources

Altered activity within the social behavior neural network in adolescent rats following prenatal alcohol exposure and/or early‐life adversity

Alcohol, Clinical and Experimental Research, EarlyView.
Prenatal alcohol exposure (PAE) and early‐life adversity (ELA) independently and interactively disrupted neural activity within the social behavior network in adolescent rats, with age‐ and sex‐specific effects. PAE primarily dampened amygdala activity, while ELA altered medial prefrontal cortex responses. These findings reveal how different early‐life
Parker J. Holman, Linda Ellis, Amanda Chao, Cecilia Mitchell, Charlis Raineki, Joanne Weinberg   +5 more
wiley   +1 more source

Chronic intermittent alcohol yields sex‐specific disruptions in cortical‐striatal‐limbic oscillations in rats

Alcohol, Clinical and Experimental Research, EarlyView.
This study shows that chronic alcohol exposure leads to sex‐specific disruptions in local field potentials, specifically causing changes to amygdala oscillations in females and prefrontal cortical and nucleus accumbens oscillations in males. These data may explain some of the sex differences observed in alcohol misuse and provide potential biomarkers ...
Kelly A. Hewitt, Skylar E. Nicholson, Madilyn J. Peterson, Lucas L. Dwiel, Angela M. Henricks   +4 more
wiley   +1 more source

Hypoactivity and neurochemical alterations in the basal ganglia of female Sprague-Dawley rats after repeated exposure to atrazine

Frontiers in Toxicology
The herbicide atrazine (ATR) has been one of the most widely used herbicides worldwide. However, due to its indiscriminate use, it has been considered an environmental contaminant. Several studies have classified ATR as an endocrine disruptor, and it has
Triana Acevedo-Huergo, Jonathan Sánchez-Yépez, María Soledad Mendoza-Trejo, Isela Hernández-Plata, Magda Giordano, Verónica Mireya Rodríguez   +5 more
doaj   +1 more source

SIRT1-FOXO3a Regulate Cocaine Actions in the Nucleus Accumbens

Journal of Neuroscience, 2015
Previous studies have shown that chronic cocaine administration induces SIRT1, a Class III histone deacetylase, in the nucleus accumbens (NAc), a key brain reward region, and that such induction influences the gene regulation and place conditioning ...
D. Ferguson, Ning-Yi Shao, E. Heller, Jian Feng, R. Neve, Hee-Dae Kim, Tanessa Call, S. Magazu, Li Shen, E. Nestler   +9 more
semanticscholar   +1 more source

Drug Predictive Cues Activate Aversion-Sensitive Striatal Neurons That Encode Drug Seeking [PDF]

, 2015
Drug-associated cues have profound effects on an addict’s emotional state and drug-seeking behavior. Although this influence must involve the motivational neural system that initiates and encodes the drug-seeking act, surprisingly little is known about ...
Dupont, Matthew J., Ebben, Amanda L., Hebron, Emily M., Robble, Mykel A., Wheeler, Daniel S., Wheeler, Robert A   +5 more
core   +2 more sources

The aporetic dialogues of Modena on gender differences: Is it all about testosterone? EPISODE I: CRIME

Andrology, EarlyView.
Abstract This is the first episode of a series of four discussions on the differences between males and females, in apparently non‐andrological fields. You will read the transcript of discussions that actually took place at the Endocrinology Unit in Modena, Italy, in the form of the aporetic dialogues of ancient Greece.
Giulia Brigante, Giulia D'Angelo, Vanessa Caccin, Silvia Coluccia, Immacolata Conte, Veronica Maria Demichelis, Rossana Cecchi, Manuela Simoni   +7 more
wiley   +1 more source

Nucleus accumbens response to gains in reputation for the self relative to gains for others predicts social media use

Frontiers in Human Neuroscience, 2013
Our reputation is important to us; we’ve experienced natural selection to care about our reputation. Recently, the neural processing of gains in reputation (positive social feedback concerning one’s character) has been shown to occur in the human ventral
Dar eMeshi, Dar eMeshi, Dar eMeshi, Dar eMeshi, Carmen eMorawetz, Carmen eMorawetz, Carmen eMorawetz, Hauke R Heekeren, Hauke R Heekeren, Hauke R Heekeren, Hauke R Heekeren   +10 more
doaj   +1 more source

Psychogenic stress activates C-Fos in nucleus accumbens-projecting neurons of the hippocampal ventral subiculum [PDF]

, 2017
Background: The ventral subiculum is known to be activated by the presentation of novel stressors. It has been hypothesized that neuronal ensembles at the ventral aspect of the hippocampal formation are involved in context-dependent processing and can ...
Dibble, SM, Grace, AA, Lipski, WJ, Rinaman, L   +3 more
core   +1 more source

Cannabidiol dose dependently reduces alcohol intake in mice via a non‐5‐HT1A receptor mechanism: Exploration of other potential receptor targets

British Journal of Pharmacology, EarlyView.
Abstract Background and Purpose Binge drinking is a risky pattern of alcohol intake and a major predictor of alcohol use disorder (AUD). Current AUD medications have limited efficacy and poor patient compliance, calling for more effective therapeutics.
Connie J. Badolato, Erin A. Lynch, Jonathon C. Arnold, Iain S. McGregor, Michael T. Bowen   +4 more
wiley   +1 more source