Results 121 to 130 of about 525,575 (332)

Epigenetic mechanisms and therapeutic innovations in chronic pain‐associated neuropsychiatric co‐morbidities

British Journal of Pharmacology, EarlyView.
Abstract Chronic pain, marked by nociceptive sensitization and maladaptive neuroplasticity, affects 30% of the global population with escalating socioeconomic burdens. Epidemiological data show a 2‐3‐fold increase in neuropsychiatric co‐morbidities among individuals with chronic pain, where epigenetic dysregulation serves as a key mechanism linking ...
Kai Zhang, Sijia Zhu, Na Xing, Zhen Zhou, Jiayi Chen, Tianen Si, Mingrui Li, Lin Jia, Yousef Rastegar‐Kashkooli, Tom J. Wang, Wei Zhu, Jing Li, Chao Jiang, Junmin Wang, Moxin Wu, Xiaoping Yin, Weidong Zang, Jian Wang, Songxue Su   +18 more
wiley   +1 more source

TRP canonical 4 and/or 5 channel inhibition reduces aversion‐ and increases reward‐responding in chronically stressed mice

British Journal of Pharmacology, EarlyView.
Abstract Background and Purpose Pharmacological inhibition of TRPC4 and/or TRPC5 channels reduces Pavlovian aversion memory in stressed mice and reduces amygdala reactivity to aversion in humans with depression. The aims of this mouse study were to improve understanding of these anxiolytic processes, determine whether there are corrective effects on ...
Giulia Poggi, Deniz Queisser, Alena Senn, Hannes Sigrist, Diana Kúkeľová, Lorraine Madur, Nagiua Cuomo‐Haymour, Mélisse Robert, Sophie Schmid, Adrián Portalés, Sophie Simard, Naguib Mechawar, Bastian Hengerer, Stefan Just, Christopher R. Pryce   +14 more
wiley   +1 more source

Individual differences in effects of stressful life events on childhood ADHD: genetic, neural, and familial contributions

Journal of Child Psychology and Psychiatry, EarlyView.
Background This study elucidates the intricate relationship between stressful life events and the development of ADHD symptoms in children, acknowledging the considerable variability in individual responses. By examining these differences, we aim to uncover the unique combinations of factors contributing to varying levels of vulnerability and ...
Seung Yun Choi, Jinwoo Lee, Junghoon Park, Eunji Lee, Bo‐Gyeom Kim, Gakyung Kim, Yoonjung Yoonie Joo, Jiook Cha   +7 more
wiley   +1 more source

Knocking Down the DRD2 by shRNA Expressing Plasmids in the Nucleus Accumbens Prevented the Disrupting Effect of Apomorphine on Prepulse Inhibition in Rat [PDF]

Journal of Sciences, Islamic Republic of Iran, 2015
Prepulse Inhibition (PPI), the objective measure of sensorimotor gating disturbance has being widely used in animal models of schizophrenia. Dopaminergic direct and indirect agonists impair PPI.
M.R. Noori-daloii, A. Shahbazi, S. Alizadeh Zendehrood, A. Shayan Nia, M. Mojarrad, M. Kheirollahi, A. Rashidi-Nezhad, A. Haghparast, F. Zare Mehrjerdi, S. Niknazar, M. Mostowfi, H. Hashemi Sotoobadi, M. Khaksari, A. R. Noori-Daloii, A. Mohammadi   +14 more
doaj  

The altered volume of striatum: A neuroimaging marker of treatment in first-episode and drug-naïve schizophrenia

Schizophrenia Research: Cognition
Although schizophrenia patients exhibit structural abnormalities in the striatum, it remains largely unknown for the role of the striatum subregions in the treatment response of antipsychotic drugs.
Gao-Xia Wei, Haoran Shen, Li-Kun Ge, Bo Cao, Roja Manohar, Xiangyang Zhang   +5 more
doaj   +1 more source

Effect of a single exercise bout on fasting cerebral blood flow and brain insulin sensitivity in middle‐aged to older adults

Experimental Physiology, EarlyView.
Abstract Reductions in brain insulin sensitivity and cerebral blood flow (CBF) have emerged as potential factors contributing to Alzheimer's disease and related dementia. However, no work has tested whether a single bout of exercise can raise brain insulin sensitivity in at‐risk adults. The aim of the study was to test whether a single bout of exercise
Steven K. Malin, Ankit M. Shah, Michal S. Berri, David H. Zald, Daniel J. Battillo   +4 more
wiley   +1 more source

EFFECTS OF REVERSIBLE INACTIVATION OF BILATERAL ACCUMBENS NUCLEI ON MEMORY STORAGE: ANIMAL STUDY IN RAT MODEL

Journal of Research in Medical Sciences, 2002
Introduction. Memory and learning play an important role in human"s life that will become problematic in case disability is weak for any reason. There are many factors that facilitate process of mamory and learning of which accumbens nucleus plays an ...
H.A ALAEI, M.R JAFARI, A.A POUSHAHNAZARI, A RAFATI, M SAAD, A.A VAFAEI   +5 more
doaj  

Early adversity and the comorbidity between metabolic disease and psychopathology

The Journal of Physiology, EarlyView.
Abstract figure legend Hierarchical diagram representing the interplay between the genetic background and early life adversities and its effect on multiple physiological processes that ultimately impact on the risk for the comorbdity between psychopathology and cardiometabolic disorders.
Ameyalli Gómez‐Ilescas, Patricia Pelufo Silveira   +1 more
wiley   +1 more source

Abstinence from cocaine self-administration promotes microglial pruning of astrocytes, which drives cocaine-seeking behavior

Cell Reports
Summary: Rodent drug self-administration leads to a compromised ability of nucleus accumbens astrocytes to maintain glutamate homeostasis as well as to reductions in surface area, volume, and synaptic colocalization of astrocyte membranes.
Anze Testen, Jonathan W. VanRyzin, Tania J. Bellinger, Ronald Kim, Han Wang, Matthew J. Gastinger, Emily A. Witt, Janay P. Franklin, Haley A. Vecchiarelli, Katherine Picard, Michael D. Scofield, Marie-Ève Tremblay, Kathryn J. Reissner   +12 more
doaj   +1 more source

Anticipation of Increasing Monetary Reward Selectively Recruits Nucleus Accumbens

Journal of Neuroscience, 2001
Brian Knutson, C. Adams, G. Fong, D. Hommer   +3 more
semanticscholar   +1 more source