Incentive learning underlying cocaine relapse requires mGluR5 receptors located on dopamine D1 receptor-expressing neurons [PDF]
, 2010 Understanding the psychobiological basis of relapse remains a challenge in developing therapies for drug addiction. Relapse in cocaine addiction often occurs following exposure to environmental stimuli previously associated with drug taking.
Bilbao, Ainhoa +11 more
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British Journal of Pharmacology, EarlyView.Background and Purpose Among all drugs of abuse, opioids cause most of the deaths and treatment seeking. Despite abundant research in multifaceted therapeutic strategies, a high rate of relapse still characterises this condition. Dopamine D3 receptor antagonists combined with cue‐exposure therapies have been proposed to ameliorate the abused drugs ...
Aurelio Franco‐García +3 more
wiley +1 more source
Translational PsychiatryQuantitative susceptibility mapping is a magnetic resonance imaging technique that measures brain tissues’ magnetic susceptibility, including iron deposition and myelination.
Shuhei Shibukawa +13 more
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Neural Mechanisms Underlying Paradoxical Performance for Monetary Incentives Are Driven by Loss Aversion [PDF]
, 2012 Employers often make payment contingent on performance in order to motivate workers. We used fMRI with a novel incentivized skill task to examine the neural processes underlying behavioral responses to performance-based pay.
Chib, Vikram S. +3 more
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British Journal of Pharmacology, EarlyView.Abstract Background and Purpose Emerging literature indicates that simultaneously targeting glucagon‐like peptide‐1 receptors (GLP‐1Rs) and neuropeptide Y receptors (Y1/Y2) may represent a new pharmacotherapeutic approach to treating opioid use disorder (OUD).
Antonia Caffrey +5 more
wiley +1 more source
Overlapping Prediction Errors in Dorsal Striatum During Instrumental Learning With Juice and Money Reward in the Human Brain [PDF]
, 2009 Prediction error signals have been reported in human imaging studies in target areas of dopamine neurons such as ventral and dorsal striatum during learning with many different types of reinforcers. However, a key question that has yet to be addressed is
O'Doherty, John P., Valentin, Vivian V.
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Alterations in the functional MRI‐based temporal brain organisation in individuals with obesity
Diabetes, Obesity and Metabolism, EarlyView.Abstract Aims Obesity is associated with functional alterations in the brain. Although spatial organisation changes in the brains of individuals with obesity have been widely studied, the temporal dynamics in their brains remain poorly understood.
Seoah Lee +3 more
wiley +1 more source
Frontiers in Neuroscience, 2017 The human nucleus accumbens is a challenging region to study using proton magnetic resonance spectroscopy (1H-MRS) on a 70-cm wide-bore clinical 3T MRI system.
Xi-Long Liu +5 more
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Neural projections from nucleus accumbens to globus pallidus, substantia innominata, and lateral preoptic-lateral hypothalamic area: an anatomical and electrophysiological investigation in the rat [PDF]
, 1983 GJ Mogenson, LW Swanson, Michael Wu
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Nucleus accumbens core lesions retard instrumental learning and performance with delayed reinforcement in the rat. [PDF]
, 2005 BACKGROUND: Delays between actions and their outcomes severely hinder reinforcement learning systems, but little is known of the neural mechanism by which animals overcome this problem and bridge such delays.
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