Results 11 to 20 of about 566,734 (334)
Nucleus Accumbens Modulation in Reward and Aversion [PDF]
Cold Spring Harbor Symposia on Quantitative Biology, 2019 The nucleus accumbens (NAc) is a key node of the brain’s circuitry that is responsible for translating motivation into action. It has been implicated in playing critical roles in virtually all forms of adaptive and pathological motivated behaviors. It is
A. Klawonn, R. Malenka
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Brain-Wide Mapping of Afferent Inputs to Accumbens Nucleus Core Subdomains and Accumbens Nucleus Subnuclei [PDF]
Frontiers in Systems Neuroscience, 2020 The nucleus accumbens (NAc) is the ventral part of the striatum and the interface between cognition, emotion, and action. It is composed of three major subnuclei: i.e., NAc core (NAcC), lateral shell (NAcLS), and medial shell (NAcMS), which exhibit ...
Liping Ma +5 more
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The Nucleus Accumbens: A Comprehensive Review [PDF]
Stereotactic and Functional Neurosurgery, 2015 There is increasing interest among functional neurosurgeons in the potential for novel therapies to impact upon diseases beyond movement disorders and pain. A target of increasing interest is the nucleus accumbens (NAc), which has long been studied as a key brain region mediating a variety of behaviors, including reward and satisfaction. As such, focal
S. Salgado, M. Kaplitt
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The Role of Neuropeptide Y in the Nucleus Accumbens [PDF]
International Journal of Molecular Sciences, 2021 Neuropeptide Y (NPY), an abundant peptide in the central nervous system, is expressed in neurons of various regions throughout the brain. The physiological and behavioral effects of NPY are mainly mediated through Y1, Y2, and Y5 receptor subtypes, which are expressed in regions regulating food intake, fear and anxiety, learning and memory, depression ...
Shunji Yamada +2 more
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The bivalent side of the nucleus accumbens [PDF]
NeuroImage, 2009 An increasing body of evidence suggests that the nucleus accumbens (NAcc) is engaged in both incentive reward processes and in adaptive responses to conditioned and unconditioned aversive stimuli. Yet, it has been argued that NAcc activation to aversive stimuli may be a consequence of the rewarding effects of their termination, i.e., relief. To address
Levita, L +5 more
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Frontiers in Behavioral Neuroscience, 2020 The anterior insular cortex is hypothesized to represent interoceptive effects of drug reward in the service of goal-directed behavior. The insula is richly connected, but the insula circuitry in addiction remains poorly characterized.
Mia Haaranen +3 more
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Loss of nucleus accumbens low-frequency fluctuations is a signature of chronic pain
Proceedings of the National Academy of Sciences of the United States of America, 2020 Significance The prevalence of chronic pain has reached epidemic levels. In addition to personal suffering, chronic pain is associated with psychiatric and medical comorbidities, notably substance misuse. Chronic pain does not have a cure or quantitative
Meena M. Makary +10 more
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Nucleus accumbens facilitates nociception [PDF]
Experimental Neurology, 2011 We have previously demonstrated an opioid link in nucleus accumbens (NAc) that mediates antinociception produced by a novel ascending pain modulation pathway. For example, noxious stimulation induces heterosegmental antinociception that is mediated by both mu- and delta-opioid receptors in NAc.
Jon D. Levine, Robert W. Gear
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Macrostructural alterations of subcortical grey matter in psychogenic erectile dysfunction. [PDF]
PLoS ONE, 2012 Psychogenic erectile dysfunction (ED) has been defined as the persistent inability to attain and maintain an erection sufficient to permit sexual performance. It shows a high incidence and prevalence among men, with a significant impact on the quality of
Nicoletta Cera +8 more
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Molecular Brain, 2022 Recent research has suggested that the mesolimbic dopamine network that mainly terminates in the nucleus accumbens may positively control the peripheral immune system.
Daisuke Sato +12 more
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