Involvement of the accumbal osteopontin-interacting transmembrane protein 168 in methamphetamine-induced place preference and hyperlocomotion in mice [PDF]
, 2017 Chronic exposure to methamphetamine causes adaptive changes in brain, which underlie dependence symptoms. We have found that the transmembrane protein 168 (TMEM168) is overexpressed in the nucleus accumbens of mice upon repeated methamphetamine ...
Fu Kequan +11 more
core +3 more sources
Gustatory reward and the nucleus accumbens [PDF]
Physiology & Behavior, 2006 The concept of reward is central to psychology, but remains a cipher for neuroscience. Considerable evidence implicates dopamine in the process of reward and much of the data derives from the nucleus accumbens. Gustatory stimuli are widely used for animal studies of reward, but the connections between the taste and reward systems are unknown.
Suriyaphun S. Mungarndee +2 more
openaire +3 more sources
Paradoxical augmented relapse in alcohol-dependent rats during deep-brain stimulation in the nucleus accumbens [PDF]
, 2016 Case reports indicate that deep-brain stimulation in the nucleus accumbens may be beneficial to alcohol-dependent patients. The lack of clinical trials and our limited knowledge of deep-brain stimulation call for translational experiments to validate ...
Canals, S. +10 more
core +2 more sources
Encoding of Aversion by Dopamine and the Nucleus Accumbens [PDF]
Frontiers in Neuroscience, 2012 Adaptive motivated behavior requires rapid discrimination between beneficial and harmful stimuli. Such discrimination leads to the generation of either an approach or rejection response, as appropriate, and enables organisms to maximize reward and minimize punishment.
McCutcheon, James E. +3 more
openaire +5 more sources
Behavioral flexibility is increased by optogenetic inhibition of neurons in the nucleus accumbens shell during specific time segments [PDF]
, 2014 Behavioral flexibility is vital for survival in an environment of changing contingencies. The nucleus accumbens may play an important role in behavioral flexibility, representing learned stimulus–reward associations in neural activity during response ...
Aquili, Luca * +4 more
core +1 more source
Frontiers in Behavioral Neuroscience, 2019 Low levels of desire and arousal are the primary sexual dysfunctions in women, necessitating neurobiological studies of sexual motivation in female animal models.
Kelsey M. Moore +5 more
doaj +1 more source
463 Childhood Emotional Neglect on Nucleus Accumbens Connectivity in Adult Survivors of Trauma
Journal of Clinical and Translational Science, 2023 OBJECTIVES/GOALS: Neuroimaging research has found that childhood maltreatment is related to reduced activation of the nucleus accumbens. The long-lasting impact of this relationship is not as well understood.
Michael T. Liuzzi +3 more
doaj +1 more source
PLoS ONE, 2016 The group I metabotropic glutamate receptors (mGluR1a and mGluR5) are important modulators of neuronal structure and function. Although these receptors share common signaling pathways, they are capable of having distinct effects on cellular plasticity ...
Kellie S. Gross +5 more
semanticscholar +1 more source
Intra-accumbens baclofen, but not muscimol, increases second order instrumental responding for food reward in rats [PDF]
, 2011 Stimulation of either GABA(A) or GABA(B) receptors within the nucleus accumbens shell strongly enhances food intake in rats. However the effects of subtype-selective stimulation of GABA receptors on instrumental responses for food reward are less well ...
Clifton, Peter G +2 more
core +2 more sources
Nucleus accumbens medium spiny neurons subtypes signal both reward and aversion
Molecular Psychiatry, 2019 Deficits in decoding rewarding (and aversive) signals are present in several neuropsychiatric conditions such as depression and addiction, emphasising the importance of studying the underlying neural circuits in detail.
C. Soares-Cunha +9 more
semanticscholar +1 more source