Results 91 to 100 of about 473,018 (289)

The tandem–random transition of cellular patterning: proposed roles of N‐cadherin‐based orientational cell adhesions in the development, maintenance, and degeneration of the nucleus pulposus

Biological Reviews, EarlyView.
ABSTRACT Intervertebral disc degeneration (IDD) can contribute to lower back and neck pain. In IDD, the most affected component of the intervertebral disc is the nucleus pulposus (NP). Derived from the notochord, where cells are organized into a tandem configuration, young NP cells cluster in three‐dimensional (3D) networks embedded in a gelatinous ...
Xiangyun Wei, Nam Vo, Gwendolyn A. Sowa
wiley   +1 more source

Propionibacterium acnes evades microbicidal phagocytosis by inhibiting the mitochondrial biogenesis of nucleus pulposus cells

The FEBS Journal, EarlyView.
P. acnes infection impairs the mitochondrial biogenesis of nucleus pulposus cells (NPCs) through the AMPK/SIRT‐1/PGC‐1α signaling pathway. This results in impaired mitochondria that are unable to generate sufficient ATP, and impaired delivery of mitochondrial reactive oxygen species to carry out the bactericidal process effectively.
Lemeng Ren, Changwei Li, Juntao Sun, Yuehuan Zheng, Yucheng Jiao, Jiancheng Zheng, Fangke Zhang, Yazhou Lin, Wenjian Wu, Peng Cao   +9 more
wiley   +1 more source

Correlation Between Proteolytic Enzymes and Microangiogenesis in Degenerative Intervertebral Disc Nucleus

Journal of Investigative Surgery, 2021
Objective To investigate the correlation between proteolytic enzymes and microangiogenesis in degenerative intervertebral disc nucleus. Methods: Forty patients with degenerative disc nucleus pulposus who were admitted to our hospital were selected incase
Dong Chen, Xin Jiang
doaj   +1 more source

Characterisation of spinal ligaments in the embryonic chick

Journal of Anatomy, EarlyView.
Use of the embryonic chick provides an opportunity to examine the maturation of spinal ligaments during development, to inform anatomical defects in the spine. Abstract Ligaments are important connective tissues within the musculoskeletal system that connect bone to bone and provide support and stability.
Sarah Hennigan, Ebru Talak Basturkmen, Rebecca A. Rolfe   +2 more
wiley   +1 more source

Nrf2 drives oxidative stress-induced autophagy in nucleus pulposus cells via a Keap1/Nrf2/p62 feedback loop to protect intervertebral disc from degeneration

Cell Death and Disease, 2019
Intervertebral disc (IVD) degeneration is known to aggravate with age and oxidative stress is implicated in the pathogenesis of many age-related diseases. Nuclear factor (erythroid-derived-2)-like 2 (Nrf2) can confer adaptive protection against oxidative
Zehan Tang, Bo Hu, Fazhi Zang, Jianxi Wang, Xing-Xing Zhang, Huajiang Chen   +5 more
semanticscholar   +1 more source

Comparative Analysis of Three Vertebral Screw Placement Directions in Anterior Thoracolumbar Fracture Surgery: A Finite Element Study

Orthopaedic Surgery, Volume 17, Issue 5, Page 1464-1477, May 2025.
This study compares the biomechanical effects of three anterior fixation systems in thoracolumbar surgery—HXTL, NHXTL, and Medtronic's CD Horizon ANTERIOR. Finite element analysis evaluates stress and displacement across vertebral bodies and support structures under varying load conditions. Results indicate the HXTL system minimizes nail–rod stress yet
Xuehai Jia, Yanjun Xie, Yi Yang, Yi Deng, Kerui Zhang, Changyong Shen, Ya Li, Litai Ma   +7 more
wiley   +1 more source

MANAJEMEN NYERI PASIEN RAWAT JALAN PADA KASUS HERNIA NUKLEUS PULPOSUS MELALUI CORE STABILITY

Jurnal Vokasi Indonesia, 2014
Herniated nucleus pulposus (HNP) is a situation where the annulus fibrosus along nucleus pulposus protruding into the spinal canal. HNP patients often complain of back pain radiating to the lower limbs, especially when bending activity.
Elsa Roselina, Safrin Arifin, Hermito Gidion   +2 more
doaj   +1 more source

Establishing a Staging System for Adjacent Segment Disease and Exploring Its Significance in Guiding Surgical Decisions: A Retrospective Study

Orthopaedic Surgery, Volume 17, Issue 5, Page 1418-1432, May 2025.
Developed a staging system for adjacent segment disease based on degeneration characteristics. Verified the feasibility and reliability of stage‐guided surgical decision‐making through surgical data, radiological data, and follow‐up data. This staging system was closely correlated with intervertebral disc degeneration and disc height while also ...
Changpeng Qu, Jianwei Guo, Hao Tao, Chuanli Zhou, Kai Zhu, Yihao Sun, Lei Li, Zhiming Liu, Hao Zhang, Xuexiao Ma   +9 more
wiley   +1 more source

Melatonin modulates IL-1β-induced extracellular matrix remodeling in human nucleus pulposus cells and attenuates rat intervertebral disc degeneration and inflammation

Aging, 2019
The inflammatory-associated factors interleukin-1β (IL-1β), interleukin-6 (IL-6) and tumor necrosis factor-α (TNF-α) are widely reported to be associated with intervertebral disc (IVD) degeneration (IVDD).
Yan Zhang, Fan He, Zhi Chen, Qihang Su, Mei-Jun Yan, Qiang Zhang, Jun Tan, Lie Qian, Yingchao Han   +8 more
semanticscholar   +1 more source

Biomechanical implications of lumbar intervertebral disc fenestration in rabbits: Comparison of ex vivo and in vivo conditions as an experimental model for chrondrodystrophic dogs with type 1 intervertebral disc disease

Veterinary Surgery, EarlyView.
Abstract Objective To compare the effect of intervertebral disc (IVD) fenestration on L3/4 range of motion (ROM) under ex vivo and in vivo conditions in a rabbit model. Study design Randomized experimental study. Animals New Zealand White rabbits (ex vivo: n = 18; in vivo: n = 12).
James D. Crowley, Rema A. Oliver, Tian Wang, Matthew H. Pelletier, William R. Walsh   +4 more
wiley   +1 more source