Results 91 to 100 of about 18,806 (262)

Injury Induces More Severe Biomechanical Changes in Middle‐Aged and Geriatric Lumbar Spines in a Mouse Ex Vivo Model

JOR SPINE, Volume 8, Issue 4, December 2025.
Injury and age exhibited an interactive effect, resulting in greater biomechanical dysfunction in middle‐aged (12 months) and geriatric (24 months) mouse intervertebral discs (IVDs), associated with age‐related proteoglycan loss and collagen denaturation as shown by FTIR and histological analyses.
Neharika Bhadouria, Justin Tiao, Angelica Baburova, Charu Jain, Bowen Wang, Antonia Demopoulos, Philip Nasser, Andrew P. Hallmark, Veeraj Shah, Jennifer R. Weiser, Deepak Vashishth, Chitra L. Dahia, Yunsoo Lee, Andrew C. Hecht, James C. Iatridis   +14 more
wiley   +1 more source

Retropulsion of Nucleus Pulposus [PDF]

BMJ, 1939
openaire   +2 more sources

The Impact of the Ovine Annular Lesion Model on IVD Pathobiology and Utility of the Ovine Spinal Model in Patho‐Anatomical Studies: A Historical Perspective

JOR SPINE, Volume 8, Issue 4, December 2025.
The ovine annular rim‐lesion model of intervertebral disc degeneration of Osti and colleagues (1990) has evolved into a sophisticated mechanical destabilization large animal model of intervertebral disc degeneration over its 35 year history offering diverse musculoskeletal multi‐disciplinary investigations into the multifunctional complexity of this ...
O. Osti, C. B. Little, J. Melrose
wiley   +1 more source

The alpha2 type IX collagen tryptophan polymorphism is associated with the severity of disc degeneration in younger patients with herniated nucleus pulposus of the lumbar spine [PDF]

, 2006
Kosaku Higashino, Yoshito Matsui, Sen Yagi, Yoichiro Takata, Tomohiro Goto, Toshinori Sakai, Shinsuke Katoh, N. Yasui   +7 more
openalex   +1 more source

Additional file 3 of Differential proteomic analysis of fetal and geriatric lumbar nucleus pulposus: immunoinflammation and age-related intervertebral disc degeneration

, 2020
Chensheng Qiu, Xiaolin Wu, Jiang Bian, Xuexiao Ma, Guoqing Zhang, Zhu Guo, Yan Wang, Yandong Ci, Qizun Wang, Hongfei Xiang, Bohua Chen   +10 more
openalex   +1 more source

Biomimetic Hydrogels for In Vitro Modelling of Nucleus Pulposus Degeneration: Effects of Extracellular Matrix Compositional Change on Physicochemical Properties and Cell Phenotype

Journal of Functional Biomaterials
The intervertebral disc, an anatomical compartment interposed between vertebral bodies, plays a key role in spine flexibility and compression loading.
Narjes Rashidi, Nicholas Dowell, Derek Covill, John Shepperd, Matteo Santin   +4 more
doaj   +1 more source

EGFR is a pivotal regulator of thrombin-mediated inflammation in primary human nucleus pulposus culture [PDF]

, 2017
Bor‐Ren Huang, Tzu-Sheng Chen, DA-TIAN BAU, I-Chen Chuang, Cheng‐Fang Tsai, Pei-Chun Chang, Dah‐Yuu Lu   +6 more
openalex   +1 more source

PIEZO1‐Primary Cilia Axis Mediates Compressive Stress‐Induced Growth Plate Degeneration and Ossification in Adolescent Idiopathic Scoliosis

JOR SPINE, Volume 8, Issue 4, December 2025.
This study investigates Adolescent Idiopathic Scoliosis (AIS), uncovering the core mechanism of mechanical stress‐induced growth plate degeneration and ossification: the mechanosensitive ion channel PIEZO1 colocalizes with primary cilia in chondrocytes, forming a signaling axis.
Fei Chen, Shuqing Chen, Fushuai Peng, Yukun Du, Jianyi Li, Yuanyuan Fan, Zichen Cui, Guanghui Gu, Han Zhang, Xingzhi Jing, Jun Dong, Tao Li, Yongming Xi   +12 more
wiley   +1 more source

BIOCHEMICAL AND BIOMECHANICAL SUBSTANTIATION OF REPARATIVE REGENERATION OF INTERVERTEBRAL DISCS IN PATIENTS WITH DEGENERATIVE DISC DISEASES

Східноукраїнський медичний журнал, 2020
Degenerative disc diseases occupy the second place in the overall structure of morbidity with temporary disability. In 40% of patients with spinal osteochondrosis, diseases of the locomotor apparatus and connective tissue cause primary disability.
J. A. Bodnarchuk, M. V. Khyzhnjak, О. О. Potapov, N. G. Chopik   +3 more
doaj  

Pharmacological Disrupting of P-eIF2α/ATF4/Ihh Signaling Protects Intervertebral Disc Degeneration Via Reducing the Reactive Oxygen Species and Apoptosis in Nucleus Pulposus Cells

, 2021
Zhanyang Qian, You Li, Renyi Kong, Junping Bao, Xin Peng, Zhimin Zhou, Kun Wang, Xin Hong, Hui Che   +8 more
openalex   +1 more source