Results 101 to 110 of about 18,806 (262)

Development of a library of laminin-mimetic peptide hydrogels for control of nucleus pulposus cell behaviors [PDF]

, 2021
Julie E. Speer, Marcos N. Barcellona, Michael Y Lu, Zizhen Zha, Liufang Jing, Munish C. Gupta, Jacob M. Buchowski, Michael P. Kelly, Lori A. Setton   +8 more
openalex   +1 more source

Lovastatin‐Loaded Nanoparticles in a Thermosensitive Chitosan Hydrogel as a Sustained Release System for Treating Intervertebral Disc Degeneration: In Vitro Cell Culture Study and In Vivo Evaluation Using a Needle‐Puncture Induced Degeneration Model in Rat Caudal Discs

JOR SPINE, Volume 8, Issue 4, December 2025.
Lovastatin‐loaded nanoparticles were developed and incorporated into a thermosensitive chitosan hydrogel for treating intervertebral disc degeneration, showing sustained lovastatin release and enhanced production of aggrecan and Type II collagen in human nucleus pulposus cells in vitro. Animal studies using a rat caudal disc model mimicking early stage
Chih‐Wei Chen, Yung‐Hsin Cheng, Kai‐Chiang Yang, Chuan‐Ching Huang, Ming‐Hsiao Hu, Yuan‐Hui Sun, Jaw‐Lin Wang, Shu‐Hua Yang   +7 more
wiley   +1 more source

Early effects of nucleus pulposus application on spinal nerve root morphology and function [PDF]

, 1998
Gunnar Byröd, Björn Rydevik, Claes Nordborg, Kjell Olmarker   +3 more
openalex   +1 more source

Mechanical characterization and design of biomaterials for nucleus pulposus replacement and regeneration [PDF]

, 2023
Z. Li, Qiuji Lu, John Robert Honiball, Sandra Hiu‐Tung Wan, Kwk Yeung, Kmc Cheung   +5 more
openalex   +1 more source

Decellularized nucleus pulposus matrix/chitosan hybrid hydrogel combined with nucleus pulposus stem cells and GDF5-loaded microspheres for intervertebral disc degeneration prevention

Molecular Medicine
Background Intervertebral disc degeneration (IDD) is considered an important pathological basis for spinal degenerative diseases. Tissue engineering is a powerful therapeutic strategy that can effectively restore the normal biological properties of disc ...
Tao Ma, Chen Liu, Quanlai Zhao, Yu Zhang, Liang Xiao   +4 more
doaj   +1 more source

Neferine alleviates intervertebral disc degeneration through KEAP1/NRF2/GPX4 and NF-κB signaling pathways

Shanghai Jiaotong Daxue xuebao. Yixue ban
Objective·To investigate the therapeutic effects of neferine (Nef) on intervertebral disc degeneration (IDD) and the underlying regulatory pathways.Methods·The effects of Nef on the viability and proliferation of nucleus pulposus cells were assessed ...
WAN Hongjin, HU Yibin, WANG Xin, ZHANG Kai, QIN An, MA Peixiang, MA Hui, ZHAO Jie   +7 more
doaj   +1 more source

On the Biology of Nucleus Pulposus [PDF]

Acta Orthopaedica Scandinavica, 1951
openaire   +2 more sources

Sulforaphane Delays Intervertebral Disc Degeneration by Alleviating Endoplasmic Reticulum Stress in Nucleus Pulposus Cells via Activating Nrf-2/HO-1 [PDF]

, 2023
Xiao Lu, Guangyu Xu, Zhidi Lin, Jian Song, Yuxuan Zhang, Hongli Wang, Feizhou Lu, Xinlei Xia, Xiaosheng Ma, Fei Zou, Jianyuan Jiang   +10 more
openalex   +1 more source

Intracellular Detection of C. acnes and S. aureus in Non‐Herniated Human Intervertebral Discs: Implications for Catabolic Signaling Pathways

JOR SPINE, Volume 8, Issue 4, December 2025.
Cutibacterium acnes and Staphylococcus aureus antigens were detected within non‐herniated intervertebral discs and correlated with catabolic and pyroptotic markers (MMP‐3, GSDMD) and PRRs including NOD2. NP cells exposed to bacterial peptidoglycan showed MAPK/NF‐κB activation and catabolic cytokine release, suggesting that bacterial sensing through a ...
Andrea Nüesch, Exarchos Kanelis, Leonidas G. Alexopoulos, Benjamin Gantenbein, Melissa Lacey, Christine L. Le Maitre   +5 more
wiley   +1 more source

Isolation and characterization of mesenchymal stem-like cells from human nucleus pulposus tissue [PDF]

, 2015
Quan Shen, Li Zhang, Baofeng Chai, Xun Ma   +3 more
openalex   +1 more source