Results 101 to 110 of about 473,018 (289)

Degenerative cervical spine disease – pathogenesis and symptoms

Studia Medyczne, 2020
Cervical discopathy is a degenerative process in the intervertebral disc and the structure of the fibrous ring. Due to the processes of proteoglycan breakdown and collagen structure, the nucleus pulposus is dehydrated and susceptible to the damaging ...
Sebastian Podlewski, Adam Kłębczyk, Maciej Radek   +2 more
doaj   +1 more source

Automated Computational Pathology to Assess Degenerative Disc Histology

JOR SPINE, Volume 8, Issue 4, December 2025.
We utilized human‐in‐the‐loop active learning methods (1) to develop the first computational pathology model to segment disc tissue (2). These segmentation outputs were used to derive shape and other measures to phenotype disc pathology which were correlated with histological scoring but also provides increased sensitivity to detect differences (3 ...
Richard D. Bell, Evie C. Reddick, David J. Lillyman, Fei San Lee, Rebecca A. Wachs   +4 more
wiley   +1 more source

Vertebral Growth Modulation Through Periosteal Resection and Fixed Length Deformity Overcorrection: Computational and In Vivo Pilot Study

JOR SPINE, Volume 8, Issue 4, December 2025.
The feasibility of using growth promoting strategies (vertebral periosteal resection and distraction) was investigated via computational and in vivo analysis. Computational analysis demonstrated that there is an increasing mechanical benefit to utilizing concave distraction over convex compression during spinal deformity correction.
Matthew A. Halanski, Cameron Jeffers, Yousuf Abubakr, Minhao Zhou, Brittney Kokinos, Max Twedt, David Bennett, Susan Hamman, Thomas Crenshaw, Grace D. O'Connell, Hani Haider   +10 more
wiley   +1 more source

The research of transgenic human nucleus pulposus cell transplantation in the treatment of lumbar disc degeneration

Kaohsiung Journal of Medical Sciences, 2019
The present study determines whether the in vivo injection of TGFβ1 and CTGF mediated by AAV2 to transfect nucleus pulposus cells in degenerative lumbar discs can reverse the biological effects of rhesus lumbar disc degeneration.
Hua‐Cong Wang, Cang‐Hai Jin, Jie Kong, Tao Yu, Jian‐Wei Guo, You‐Gu Hu, Yong Liu   +6 more
doaj   +1 more source

MiR-125a Rs12976445 Polymorphism is Associated with the Apoptosis Status of Nucleus Pulposus Cells and the Risk of Intervertebral Disc Degeneration

Cellular Physiology and Biochemistry, 2016
Background: Spinal degenerative diseases are a major health problem and social burden worldwide. Intervertebral disc degeneration (IDD) is the pathological basis of spinal degenerative diseases and is characterized by loss of nucleus pulposus cells due ...
Jin Feng Ma, Li Na Zang, Yong Ming Xi, Wen Jiu Yang, Debo Zou   +4 more
doaj   +1 more source

Gene‐Hydrogel Microenvironment Regulates Extracellular Matrix Metabolism Balance in Nucleus Pulposus

Advancement of science, 2019
Gene therapy provides an ideal potential treatment for intervertebral disk degeneration by delivering synthetic microRNAs (miRNAs) to regulate the gene expression levels.
Wei Chen, Hao Chen, Dandan Zheng, Hongbo Zhang, L. Deng, W. Cui, Yuhui Zhang, H. Santos, Hongxing Shen   +8 more
semanticscholar   +1 more source

Age and Spinal Level as Predictors of Lumbar Disc Degeneration in Humans and Mice: A Comparative Analysis

JOR SPINE, Volume 8, Issue 4, December 2025.
Mouse models are commonly used to study IVD degeneration and related neurological conditions that especially impact elder population. However, how well mice replicate human pathology remains unclear. This study compared lumbar IVD degeneration patterns across age and spinal levels in humans and mice.
Ravij Mehta, Sarthak Mohanty, Andrew Parker Hallmark, Veeraj Shah, Tom Ross, Eric A. Bogner, Tejbir S. Pannu, Mathieu Bannwarth, Sohrab Virk, Sravisht Iyer, James C. Farmer, Russel C. Huang, Darren R. Lebl, Bernard A. Rawlins, Harvinder S. Sandhu, Han Jo Kim, Matthew E. Cunningham, Sheeraz Qureshi, Todd J. Albert, Chitra L. Dahia   +19 more
wiley   +1 more source

IL-1β increases asporin expression via the NF-κB p65 pathway in nucleus pulposus cells during intervertebral disc degeneration

Scientific Reports, 2017
Disc degeneration (DD) is a multifaceted chronic process that alters the structure and function of intervertebral discs. The pathophysiology of degeneration is not completely understood, but the consensus is that changes in genes encoding extracellular ...
Shengjie Wang, Chao Liu, Zhongyi Sun, Peng Yan, He Liang, Kai Huang, Changwei Li, Jiwei Tian   +7 more
doaj   +1 more source

Characterization of the age-dependent intervertebral disc changes in rabbit by correlation between MRI, histology and gene expression

BMC Musculoskeletal Disorders, 2011
Background The present study was conducted to address whether the intervertebral disc of rabbit could be considered (i) as a valuable model to provide new insights into the tissue and cellular changes of Nucleus pulposus aging and (ii) as an appropriate ...
Gauthier Olivier, Fellah Borhane H, Lesoeur Julie, Masson Martial, Grimandi Gaël, Pot-Vaucel Marianne, Clouet Johann, Fusellier Marion, Cherel Yan, Maugars Yves, Guicheux Jérôme, Vinatier Claire   +11 more
doaj   +1 more source

Reduced Shear Modulus and Altered Lamellar Morphology of the Outer Annulus Fibrosus in Painful Intervertebral Disc Degeneration Compared With Tissue From Non‐Surgical Controls

JOR SPINE, Volume 8, Issue 4, December 2025.
Disc degeneration (DD) results in a mechanically dysfunctional disc through progressive loss of the intervertebral disc's (IVD) highly organized structure. This study measured shear and structure properties of the outer annulus fibrosus in surgical DD and minimally degenerative (non‐DD) donor individuals.
Taylor J. Bader, Manmeet Dhiman, Lucas Lo Vercio, Jacques Bouchard, Fred Nicholls, Nathan Evaniew, Bradley Jacobs, Kenneth C. Thomas, Paul Salo, David A. Hart, Neil A. Duncan, Ganesh Swamy   +11 more
wiley   +1 more source