Results 111 to 120 of about 18,806 (262)

Mitochondrial DNA induces nucleus pulposus cell pyroptosis via the TLR9-NF-κB-NLRP3 axis [PDF]

, 2023
Lü Peng, Huayong Zheng, Hao Meng, Chuan Liu, Lianhong Duan, Jianzheng Zhang, Zhicheng Zhang, Jie Gao, Yang Zhang, Tiansheng Sun   +9 more
openalex   +1 more source

Development and Characterization of a Tunable PDMS Substrate Model for Investigating Elastic Properties and Mechanical Stretching in Intervertebral Disc Cells

JOR SPINE, Volume 8, Issue 4, December 2025.
This study introduces a tunable PDMS stretching platform to examine annulus fibrosus cell responses to combined substrate stiffness and mechanical loading. By integrating a Sylgard 184/527 mix, the platform provides a stiffness range of 9–240 kPa and enables cyclic strain application while preserving viability with stiffness‐ and strain‐dependent ...
Johannes Hasler, Mikkael Lamoca, Kory Schimmelpfennig, Shuhuan Zhang, Wolfgang Hitzl, Sami Farajollahi, Vinay V. Abhyankar, Christopher L. Lewis, Rui Liu, Karin Wuertz‐Kozak   +9 more
wiley   +1 more source

Chordoma‐derived cell line U‐CH1‐N recapitulates the biological properties of notochordal nucleus pulposus cells

, 2016
Nobuyuki Fujita, Satoshi Suzuki, Kota Watanabe, Ken Ishii, Ryuichi Watanabe, Masayuki Shimoda, Keiyo Takubo, Takashi Tsuji, Yoshiaki Toyama, Takeshi Miyamoto, Keisuke Horiuchi, Masaya Nakamura, Morio Matsumoto   +12 more
openalex   +1 more source

Evaluation of Lumbar Intervertebral Disc and Facet Joint Degeneration Using Histogram Analysis of T2 and T2* Values

JOR SPINE, Volume 8, Issue 4, December 2025.
Histogram Assessment of Lumbar Intervertebral Disc and Facet Joint Degeneration. ABSTRACT Background Lumbar facet joint (LFJ) and intervertebral disc (IVD) degeneration are the common causes of low back pain. The aim of this study is to explore the feasibility of histogram analysis of T2 and T2* values on grading LFJ and IVD degeneration and to examine
Xiaoqing Liang, Yitong Li, Bowen Hou, Yan Xiong, John Morelli, Weiyin Vivian Liu, Xiaoming Li   +6 more
wiley   +1 more source

Referee report. For: The role of single nucleotide polymorphisms of IL-1A -889C>T (rs1800587), TNF-A -238G>A (rs361525), and VDR TaqI (rs731236) on susceptibility to herniated nucleus pulposus [version 1; peer review: 1 approved with reservations]

, 2021
Ismail Hadisoebroto dilogo
openalex   +1 more source

Macrophage Subtypes Distinctly Impact Intervertebral Disc Inflammation and Extracellular Matrix Composition

JOR SPINE, Volume 8, Issue 4, December 2025.
Intervertebral disc (IVD) degeneration induces an inflammatory microenvironment causing macrophage migration. Macrophages can impact both inflammation and the extracellular matrix (ECM) of the IVD, with the effects dependent on macrophage polarization to the pro‐inflammatory M1 or anti‐inflammatory M2 phenotype.
Lauren E. Lisiewski, Leonardo Campos, Timothy D. Jacobsen, Min Kyu M. Kim, Nadeen O. Chahine   +4 more
wiley   +1 more source

Injectable ECM-mimetic dynamic hydrogels abolish ferroptosis-induced post-discectomy herniation through delivering nucleus pulposus progenitor cell-derived exosomes

Nature Communications
Discectomy-induced ferroptosis of nucleus pulposus cells (NPCs) contributes to postoperative lumbar disc herniation (LDH) recurrence and intervertebral disc degeneration (IDD).
Wenkai Wang, Zhuo Cheng, Miao Yu, Ke Liu, Hongli Duan, Yang Zhang, Xinle Huang, Menghuan Li, Changqing Li, Yan Hu, Zhong Luo, Minghan Liu   +11 more
doaj   +1 more source

Acidic pH promotes nucleus pulposus cell senescence through activating the p38 MAPK pathway [PDF]

, 2018
Jiabin Fu, Wei Yu, Dianming Jiang
openalex   +1 more source

Comparison of the differentiation abilities of bone marrow‑derived mesenchymal stem cells and adipose‑derived mesenchymal stem cells toward nucleus pulposus‑like cells in three‑dimensional culture

, 2021
Xuejun Dai, Yanyu Guan, Zhongzi Zhang, Ying Xiong, Chengwei Liu, Haifeng Li, Bailian Liu   +6 more
openalex   +2 more sources

An Ex Vivo Model of Intervertebral Disc Degeneration for Assessing Retention of Injectable Cell‐Based Grafts

JOR SPINE, Volume 8, Issue 4, December 2025.
An ex vivo model of intervertebral disc (IVD) degeneration was generated using chondroitinase ABC (ChABC) and pro‐inflammatory cytokines (Infl) and used for assessing retention of injectable cell‐based grafts, namely nasal chondrocyte spheroids (NCS). ABSTRACT Introduction Cell therapies for painful intervertebral disc (IVD) degeneration (IDD) have not
Raphael Schmid, Janhavi Apte, Elias Schulze, Andrej Sirek, Günther Schäfer, Jessica Schäper, Francesco Santini, Simona Negoias, Andrea Barbero, Ivan Martin, Karoliina Pelttari, Stefan Schären, Olga Krupkova, Arne Mehrkens   +13 more
wiley   +1 more source