Results 111 to 120 of about 482,535 (309)

Macrophage Efferocytosis as a Therapeutic Strategy in Intervertebral Disc Degeneration

Cell Proliferation, EarlyView.
Macrophages, integral to degenerated intervertebral discs, play a critical role in disc degeneration. By performing efferocytosis, they clear apoptotic cells. This article explores the process of efferocytosis, its molecular mechanisms, potential therapeutic implications for intervertebral disc degeneration and future strategies for targeted treatments.
Shijie Chen, Haijun Zhang, Zhaoheng Wang, Daxue Zhu, Yanhu Li, Yizhi Zhang, Dongxin Wang, Shuwei Chen, Huan Liu, Xuewen Kang   +9 more
wiley   +1 more source

Nrf2 drives oxidative stress-induced autophagy in nucleus pulposus cells via a Keap1/Nrf2/p62 feedback loop to protect intervertebral disc from degeneration

Cell Death and Disease, 2019
Intervertebral disc (IVD) degeneration is known to aggravate with age and oxidative stress is implicated in the pathogenesis of many age-related diseases. Nuclear factor (erythroid-derived-2)-like 2 (Nrf2) can confer adaptive protection against oxidative
Zehan Tang, Bo Hu, Fazhi Zang, Jianxi Wang, Xing-Xing Zhang, Huajiang Chen   +5 more
semanticscholar   +1 more source

In vitro measurement of nucleus pulposus swelling pressure: A new technique for studies of spinal adaptation to gravity [PDF]

Swelling of the intervertebral disc nucleus pulposus is altered by posture and gravity. We have designed and tested a new osmometer for in vitro determination of nucleus pulposus swelling pressure.
Ballard, R., Brown, M. D., Garfin, S. R., Glover, M. G., Gott, S., Hargens, A. R., Mahmood, M. M., Murthy, G.   +7 more
core   +1 more source

Melatonin modulates IL-1β-induced extracellular matrix remodeling in human nucleus pulposus cells and attenuates rat intervertebral disc degeneration and inflammation

Aging, 2019
The inflammatory-associated factors interleukin-1β (IL-1β), interleukin-6 (IL-6) and tumor necrosis factor-α (TNF-α) are widely reported to be associated with intervertebral disc (IVD) degeneration (IVDD).
Yan Zhang, Fan He, Zhi Chen, Qihang Su, Mei-Jun Yan, Qiang Zhang, Jun Tan, Lie Qian, Yingchao Han   +8 more
semanticscholar   +1 more source

Extracellular vesicles from adipose‐derived mesenchymal stem cells prevent high glucose‐induced retinal ganglion cell pyroptosis through a microRNA‐26a‐5p‐dependent mechanism

Journal of Diabetes Investigation, EarlyView.
ADSC‐EVs carrying miR‐26a‐5p confer protection against RGC pyroptosis by targeting HDAC4 and activating H3K27ac‐dependent Nrf2 expression. ABSTRACT Objective Mesenchymal stromal/stem cells have neuroprotective effects that limit damage to the retina, which is predominantly mediated by the released extracellular vesicles (EVs).
Lei Tang, Jian Zhang, Jianping Gao
wiley   +1 more source

Penatalaksanaan Fisioterapi pada Ischialgia e.c Hernia Nucleus Pulposus di RSUD DR. Loekmono Hadi Kudus [PDF]

, 2018
THE MANAGEMENT OF PHYSIOTHERAPY TOWARD ISCHIALGIA e.c HERNIA NUCLEUS PULPOSUS IN RSUD DR. LOEKMONO HADI KUDUS (RISKA ANNISA, 2018) Background : Back pain is often felt between the lower back to folding the lower back of lumbar or lumbosacral areas ...
Annisa, Riska
core  

Current strategies for treatment of intervertebral disc degeneration: substitution and regeneration possibilities [PDF]

, 2017
Background: Intervertebral disc degeneration has an annual worldwide socioeconomic impact masked as low back pain of over 70 billion euros. This disease has a high prevalence over the working age class, which raises the socioeconomic impact over the ...
A Joshi, A LA Binch, a S Htay, A Schmocker, A Thorvaldsson, AA Marino, AA Thorpe, AT Reza, AT Reza, ATH Choy, ATH Choy, B Gantenbein-Ritter, B Xu, B Xu, BH Wang, BI Woods, BJC Freeman, BP Chan, C Zhu, C-Q Zhao, CC Guterl, CC Guterl, CL Le Maitre, D Denning, D Puppi, D Purmessur, D Périé, DDN Sun, DF Coutinho, DJ Aguiar, DR Pereira, E Alsberg, EA Growney Kalaf, EH Cassinelli, ES Place, F Wang, G Chang, G Crevensten, G Feng, G Khang, G Pattappa, G Vadalà, GR Buttermann, H Cheng, H Tao, H-J Wilke, HA Lin, J Berger, J Naresh-Babu, J Silva-Correia, J Silva-Correia, J Silva-Correia, J Silva-Correia, J Silva-Correia, J Zhu, JC Iatridis, JD Thomas, JF DeLucca, JF Mano, JL Bron, JM Lee, JP Jarman, JP Thompson, JPG Urban, JS Temenoff, JT Martin, JT Martin, JT Oliveira, JT Oliveira, JWS Hayami, K Rezwan, K Takahashi, K-W Kim, KD Hudson, KL Spiller, L Calderon, L Jiang, L Koepsell, L Saad, L Xin, LA Nasto, LJ Suggs, LM Benneker, LM Boyd, M Endres, M Likhitpanichkul, M Sato, M Yasen, MB Coventry, MC Cornejo, MS Gupta, MS Gupta, N Bangel-Ruland, N Wismer, P Heneghan, P Roughley, P Schexnailder, P-PA Vergroesen, PB Malafaya, PY Neo, Q Guo, R Chou, RD Abbott, RD Bowles, RG Long, S Roberts, S Roberts, S van Uden, S Varghese, S-H Park, SBG Blanquer, SCW Chan, SK Leckie, SM Mueller, SM Richardson, SM Richardson, SR Van Tomme, T Oner, T Pirvu, TK Chik, V Stroganov, WC Bae, X Tang, X Zhou, Y Tao, Y Wu, Y-C Huang, Z Fang, Z Karimi, Z Sun   +129 more
core   +1 more source

Characterisation of spinal ligaments in the embryonic chick

Journal of Anatomy, EarlyView.
Use of the embryonic chick provides an opportunity to examine the maturation of spinal ligaments during development, to inform anatomical defects in the spine. Abstract Ligaments are important connective tissues within the musculoskeletal system that connect bone to bone and provide support and stability.
Sarah Hennigan, Ebru Talak Basturkmen, Rebecca A. Rolfe   +2 more
wiley   +1 more source

Degenerative cervical spine disease – pathogenesis and symptoms

Studia Medyczne, 2020
Cervical discopathy is a degenerative process in the intervertebral disc and the structure of the fibrous ring. Due to the processes of proteoglycan breakdown and collagen structure, the nucleus pulposus is dehydrated and susceptible to the damaging ...
Sebastian Podlewski, Adam Kłębczyk, Maciej Radek   +2 more
doaj   +1 more source

Injectable laminin-functionalized hydrogel for nucleus pulposus regeneration. [PDF]

, 2013
Cell delivery to the pathological intervertebral disc (IVD) has significant therapeutic potential for enhancing IVD regeneration. The development of injectable biomaterials that retain delivered cells, promote cell survival, and maintain or promote an NP
Bowles, RD, Brunger, JM, Chen, YT, Francisco, AT, Guilak, F, Mancino, RJ, Richardson, WJ, Setton, LA, Tainter, DM   +8 more
core   +1 more source