Results 121 to 130 of about 18,806 (262)

Is Pain Blockage Safe? The Viewpoint Based on Nucleus Pulposus Cell Cytotoxicity [PDF]

, 2014
Sung Uk Kuh, Minjae Kang, K. H. Kim, Jun Yong Park   +3 more
openalex   +1 more source

Intervertebral Disc Proteoglycans: Multifunctional Tissue Stabilizing and Instructional Cell Regulatory Proteins That Control Tissue Homeostasis

JOR SPINE, Volume 8, Issue 4, December 2025.
Matrix and cell‐associated proteoglycans are important tissue‐stabilizing, weight‐bearing, and tension‐resisting proteins in the intervertebral disc. Their glycosaminoglycan components have growth factor binding and cell‐instructive properties that allow cells to regulate tissue composition and function.
James Melrose
wiley   +1 more source

Hypoxia-inducible Factor (HIF)-1α and CCN2 Form a Regulatory Circuit in Hypoxic Nucleus Pulposus Cells [PDF]

, 2013
Cassie M. Tran, Nobuyuki Fujita, Bau‐Lin Huang, Jessica R. Ong, Karen M. Lyons, Irving M. Shapiro, Makarand V. Risbud   +6 more
openalex   +1 more source

Regenerative Potential of Extracellular Vesicles on Intervertebral Disc Degeneration: What is the EV‐idence?

JOR SPINE, Volume 8, Issue 4, December 2025.
Summary of the considerations for EV research in the intervertebral disc (IVD) field. Blue text = critical for IVD field when conducting EV functional studies; bold blue exclamation mark = minimal MISEV requirements. EV, Extracellular vesicles; cryo‐EM, cryo‐electron microscopy; hrFC, high‐resolution flow cytometry; MRI, magnetic resonance imaging; NTA,
Daniele Corraini, Chantal Voskamp, Marca H. M. Wauben, Marianna A. Tryfonidou   +3 more
wiley   +1 more source

Understanding the Physiological Behavior of Disc Cells in an In Vitro Imitation of the Healthy and Degenerated Disc Niche

JOR SPINE, Volume 8, Issue 4, December 2025.
Here, the development of media compositions to mimic the healthy and degenerate IVD has been achieved. Human NP cells and explants were successfully cultured within these media without any detectable loss of viability and minimal secretomic changes. The main effects observed within cultures were seen with the addition of physiological concentrations of
Joseph Snuggs, Shaghayegh Basatvat, Exarchos Kanelis, Abbie Binch, Leonidas Alexopoulos, Marianna A. Tryfonidou, Christine Le Maitre   +6 more
wiley   +1 more source

A Multiscale Ex Vivo Method to Investigate Intervertebral Disc Strain and Fiber Recruitment in Anterolateral Bending Using 9.4T MRI‐DVC and DIC Microscopy

JOR SPINE, Volume 8, Issue 4, December 2025.
Ultrahigh‐field MRI‐based digital volume correlation combined with optical DIC microscopy enables direct linkage of three‐dimensional disc strain fields with collagen fiber recruitment across multiple length scales. Applied to anterolaterally bent porcine cervical discs, these multiscale approaches revealed pronounced regional strain heterogeneity and ...
T. D. Slater, K. A. Raftery, V. M. van Heeswijk, A. Thambyah, N. Newell   +4 more
wiley   +1 more source

Nucleus pulposus cells regulate macrophages in degenerated intervertebral discs via the integrated stress response-mediated CCL2/7-CCR2 signaling pathway [PDF]

Shuo Tian, Xuanzuo Chen, Wei Wu, Hui Lin, Xiangcheng Qing, Sheng Liu, Baichuan Wang, Yan Xiao, Zengwu Shao, Yizhong Peng   +9 more
openalex   +1 more source

Diagnostic accuracy of contrast and non-contrast 1.5 tesla magnetic resonance imaging for lumbar herniated nucleus pulposus based on surgical findings

, 2022
Endra Wibisono Harmawan, Tedy Apriawan, Eko Agus Subagio, Muhammad Faris, Sri Andreani Utomo, Budi Utomo, Abdul Hafid Bajamal   +6 more
openalex   +2 more sources

Musculoskeletal Diseases: Mechanisms and Therapeutic Advances

MedComm, Volume 6, Issue 12, December 2025.
Musculoskeletal diseases comprise a broad spectrum of inflammatory, degenerative, and neoplastic disorders. Increasing evidence highlights the central role of immune regulation in their pathogenesis, with complex interactions among immune, bone, muscle, and stromal cells.
Xiao Ma, Eloy Yinwang, Xupeng Chai, Fangqian Wang, Zehao Chen, Shengdong Wang, Hao Zhou, Yucheng Xue, Jiangchu Lei, Fanglu Chen, Hengyuan Li, Shixin Chen, Shenzhi Zhao, Kelei Wang, Liang Chen, Junjie Gao, Zhaoming Ye, Nong Lin   +17 more
wiley   +1 more source

Immunomodulatory Biomaterials for Bone and Soft Tissue Chronic Inflammation Diseases

Small Science, Volume 5, Issue 12, December 2025.
This review analyzes immunomodulatory biomaterial strategies for treating chronic inflammatory disorders in bone and soft tissues. It explores emerging mechanisms for resolving inflammation while promoting tissue regeneration, offering insights for developing targeted immunotherapeutic approaches that bridge material science with immunology for ...
Yiming Li, Xudong Xie, Chong Ding, Shengming Zhang, Liangcong Hu, Bobin Mi, Mengfei Liu, Guohui Liu   +7 more
wiley   +1 more source