Results 121 to 130 of about 482,535 (309)
Orthopaedic Surgery, Volume 17, Issue 5, Page 1464-1477, May 2025.This study compares the biomechanical effects of three anterior fixation systems in thoracolumbar surgery—HXTL, NHXTL, and Medtronic's CD Horizon ANTERIOR. Finite element analysis evaluates stress and displacement across vertebral bodies and support structures under varying load conditions. Results indicate the HXTL system minimizes nail–rod stress yet
Xuehai Jia +7 more
wiley +1 more source
Journal of Pharmacological Sciences, 2018 Objective: Intervertebral disc degeneration was characterized with aberrant intervertebral disc nucleus pulposus cells apoptosis. MiR-532 was reported to be up-regulated in the patients with intervertebral disc degeneration.
Zeyu Sun +3 more
doaj
Cellular Physiology and Biochemistry, 2016 Background: Spinal degenerative diseases are a major health problem and social burden worldwide. Intervertebral disc degeneration (IDD) is the pathological basis of spinal degenerative diseases and is characterized by loss of nucleus pulposus cells due ...
Jin Feng Ma +4 more
doaj +1 more source
The Poisson’s ratio of the nucleus pulposus is strain dependent [PDF]
, 2012 Part of the Soft Tissue Biomechanics Session this presentation is to characterise the true Poisson’s ratio of the nucleus pulposus is strain ...
Farrell, Mark, Riches, Philip
core
Molecular characterization of chordoma xenografts generated from a novel primary chordoma cell source and two chordoma cell lines. [PDF]
, 2014 OBJECT: Chordoma cells can generate solid-like tumors in xenograft models that express some molecular characteristics of the parent tumor, including positivity for brachyury and cytokeratins. However, there is a dearth of molecular markers that relate to
Alcorta, David A +10 more
core +1 more source
Gene‐Hydrogel Microenvironment Regulates Extracellular Matrix Metabolism Balance in Nucleus Pulposus
Advancement of science, 2019 Gene therapy provides an ideal potential treatment for intervertebral disk degeneration by delivering synthetic microRNAs (miRNAs) to regulate the gene expression levels.
Wei Chen +8 more
semanticscholar +1 more source
Orthopaedic Surgery, Volume 17, Issue 5, Page 1418-1432, May 2025.Developed a staging system for adjacent segment disease based on degeneration characteristics. Verified the feasibility and reliability of stage‐guided surgical decision‐making through surgical data, radiological data, and follow‐up data. This staging system was closely correlated with intervertebral disc degeneration and disc height while also ...
Changpeng Qu +9 more
wiley +1 more source
Kaohsiung Journal of Medical Sciences, 2019 The present study determines whether the in vivo injection of TGFβ1 and CTGF mediated by AAV2 to transfect nucleus pulposus cells in degenerative lumbar discs can reverse the biological effects of rhesus lumbar disc degeneration.
Hua‐Cong Wang +6 more
doaj +1 more source
Mohawk promotes the maintenance and regeneration of the outer annulus fibrosus of intervertebral discs. [PDF]
, 2016 The main pathogenesis of intervertebral disc (IVD) herniation involves disruption of the annulus fibrosus (AF) caused by ageing or excessive mechanical stress and the resulting prolapse of the nucleus pulposus.
Asahara, Hiroshi +14 more
core +1 more source
Composite Hydrogels for the Replacement of the Nucleus Pulposus [PDF]
, 2009 The intervertebral disc (IVD), which provides flexibility to the spine and facilitates damping and motion, is composed of two distinct structures: the annulus fibrosus (AF) and the nucleus pulposus (NP). The AF, which is fibrous and elastic, confines the NP, a gel-like material, containing 65 to 90% of water.
openaire +2 more sources