Results 61 to 70 of about 18,919 (201)

Comparative Analysis of Three Vertebral Screw Placement Directions in Anterior Thoracolumbar Fracture Surgery: A Finite Element Study

Orthopaedic Surgery, Volume 17, Issue 5, Page 1464-1477, May 2025.
This study compares the biomechanical effects of three anterior fixation systems in thoracolumbar surgery—HXTL, NHXTL, and Medtronic's CD Horizon ANTERIOR. Finite element analysis evaluates stress and displacement across vertebral bodies and support structures under varying load conditions. Results indicate the HXTL system minimizes nail–rod stress yet
Xuehai Jia, Yanjun Xie, Yi Yang, Yi Deng, Kerui Zhang, Changyong Shen, Ya Li, Litai Ma   +7 more
wiley   +1 more source

Establishing a Staging System for Adjacent Segment Disease and Exploring Its Significance in Guiding Surgical Decisions: A Retrospective Study

Orthopaedic Surgery, Volume 17, Issue 5, Page 1418-1432, May 2025.
Developed a staging system for adjacent segment disease based on degeneration characteristics. Verified the feasibility and reliability of stage‐guided surgical decision‐making through surgical data, radiological data, and follow‐up data. This staging system was closely correlated with intervertebral disc degeneration and disc height while also ...
Changpeng Qu, Jianwei Guo, Hao Tao, Chuanli Zhou, Kai Zhu, Yihao Sun, Lei Li, Zhiming Liu, Hao Zhang, Xuexiao Ma   +9 more
wiley   +1 more source

Clinical Efficacy and Safety of Arthroscopic‐Assisted Uniportal Spinal Surgery Versus Percutaneous Endoscopic Lumbar Decompression in Lumbar Spinal Stenosis: A Retrospective Study

Orthopaedic Surgery, EarlyView.
Arthroscopic‐assisted uniportal spinal surgery (AUSS), a novel minimally invasive approach, demonstrates superior clinical outcomes in managing lumbar spinal stenosis (LSS), notably in achieving efficient surgery, complete neural decompression, and sustained postoperative symptom relief.
Huihao Zhang, Zijie Dong, Wei Liu, Feifei Pu, Junqing Cao, Shiyang Du, Mi Huang, Lin Yang, Xiaolong Zhao, Junhui Wang, Hongfeng Ruan, Jing Feng, En Song, Juan Zhou   +13 more
wiley   +1 more source

Degenerative cervical spine disease – pathogenesis and symptoms

Studia Medyczne, 2020
Cervical discopathy is a degenerative process in the intervertebral disc and the structure of the fibrous ring. Due to the processes of proteoglycan breakdown and collagen structure, the nucleus pulposus is dehydrated and susceptible to the damaging ...
Sebastian Podlewski, Adam Kłębczyk, Maciej Radek   +2 more
doaj   +1 more source

Arthroscopic‐Assisted Uni‐Portal Spinal Surgery Combined With Kirschner Wire Anchoring for Cervical Spondylotic Radiculopathy: A Technical Note and Preliminary Clinical Results

Orthopaedic Surgery, EarlyView.
This study is the first to describe the use of arthroscopic‐assisted uniportal spinal surgery (AUSS) with Kirschner‐wire anchoring in a cohort of 15 patients with cervical spondylotic radiculopathy (CSR). Postoperatively, patients experienced significant pain relief and marked improvement in cervical function.
Shan Wu, Jiaxuan Zhang, Renjie Dong, Yihang He, Feng Huang, Zhenyuan Lu, Yang Liu, Guosheng Zhao, Zhenyong Ke, Yang Wang   +9 more
wiley   +1 more source

CRISPR/dCas9-Mediated Parkin Inhibition Impairs Mitophagy and Aggravates Apoptosis of Rat Nucleus Pulposus Cells Under Oxidative Stress [PDF]

, 2021
Tao Lan, Yuchen Zheng, Ningdao Li, Xiaosheng Chen, Zhe Shen, Bin Yan   +5 more
openalex   +1 more source

Canonical and non‐canonical functions of proteins regulating mitochondrial dynamics in mammalian physiology

The Journal of Physiology, EarlyView.
Abstract figure legend Mitochondria are highly dynamic organelles that continuously remodel their architecture through coordinated cycles of fusion and fission. This review examines the four key GTPases that orchestrate mitochondrial dynamics in mammals: MFN1, MFN2, OPA1, and DRP1.
Rémi Chaney, Vincent Marcangeli, Krystel Desjardins, Shima Taherkhani, Gilles Gouspillou   +4 more
wiley   +1 more source

The research of transgenic human nucleus pulposus cell transplantation in the treatment of lumbar disc degeneration

Kaohsiung Journal of Medical Sciences, 2019
The present study determines whether the in vivo injection of TGFβ1 and CTGF mediated by AAV2 to transfect nucleus pulposus cells in degenerative lumbar discs can reverse the biological effects of rhesus lumbar disc degeneration.
Hua‐Cong Wang, Cang‐Hai Jin, Jie Kong, Tao Yu, Jian‐Wei Guo, You‐Gu Hu, Yong Liu   +6 more
doaj   +1 more source

MiR-125a Rs12976445 Polymorphism is Associated with the Apoptosis Status of Nucleus Pulposus Cells and the Risk of Intervertebral Disc Degeneration

Cellular Physiology and Biochemistry, 2016
Background: Spinal degenerative diseases are a major health problem and social burden worldwide. Intervertebral disc degeneration (IDD) is the pathological basis of spinal degenerative diseases and is characterized by loss of nucleus pulposus cells due ...
Jin Feng Ma, Li Na Zang, Yong Ming Xi, Wen Jiu Yang, Debo Zou   +4 more
doaj   +1 more source

IL-1β increases asporin expression via the NF-κB p65 pathway in nucleus pulposus cells during intervertebral disc degeneration

Scientific Reports, 2017
Disc degeneration (DD) is a multifaceted chronic process that alters the structure and function of intervertebral discs. The pathophysiology of degeneration is not completely understood, but the consensus is that changes in genes encoding extracellular ...
Shengjie Wang, Chao Liu, Zhongyi Sun, Peng Yan, He Liang, Kai Huang, Changwei Li, Jiwei Tian   +7 more
doaj   +1 more source