Results 71 to 80 of about 482,535 (309)
Nucleus pulposus explant culture model [PDF]
Journal of Orthopaedic Research, 2009 AbstractMany of the therapeutic interventions for intervertebral disc degeneration attempt to repopulate the nucleus pulposus (NP) tissue; however, NP cells are heterogeneous and not well characterized. To address this, we have investigated the morphology, extracellular gene and protein expression, and apoptosis changes in NP explants cultured in vitro
Gang Feng +4 more
openaire +3 more sources
Advanced Materials, EarlyView.This review highlights recent progress in piezoelectric materials for regenerative medicine, emphasizing their ability to convert mechanical stimuli into bioelectric signals that promote tissue repair. Key discussions cover the intrinsic piezoelectric properties of biological tissues, co‐stimulation cellular mechanisms for tissue regeneration, and ...
Xinyu Wang +3 more
wiley +1 more source
Poisson’s ratio of nucleus pulposus tissue : comparison of experimental results with a biphasic poroviscoelastic finite element model [PDF]
, 2012 This presentation looks at Poisson’s ratio of nucleus pulposus tissue, comparison of experimental results with a biphasic poroviscoelastic finite element ...
Farrell, Mark, Riches, Philip
core
Prevalence and breed predisposition for thoracolumbar intervertebral disc disease in cats [PDF]
, 2016 Objectives The objective was to evaluate the prevalence and possible breed predilections for thoracolumbar intervertebral disc disease (IVDD) in cats. Methods Medical records and imaging studies of cats diagnosed with thoracolumbar IVDD between January ...
De Decker, S, Volk, H A, Warner, A-S
core +1 more source
Stiffness of photocrosslinkable gelatin hydrogel influences nucleus pulposus cell propertiesin vitro
Journal of Cellular and Molecular Medicine, 2020 A key early sign of degenerative disc disease (DDD) is the loss of nucleus pulposus (NP) cells (NPCs). Accordingly, NPC transplantation is a treatment strategy for intervertebral disc (IVD) degeneration. However, in advanced DDD, due to structural damage
Panpan Xu +8 more
semanticscholar +1 more source
Advanced Science, EarlyView.Inflammatory dysregulation drives intervertebral disc degeneration via stage‐dependent immune cellular dynamics. Single‐cell transcriptomics and genetic risk mapping revealed a shift from LCN2high myeloid‐derived suppressor cells maintaining disc repair in early stages to IL1B+ macrophage‐dominated pathology in advanced disease.
Changmeng Zhang +6 more
wiley +1 more source
Exhaustion of nucleus pulposus progenitor cells with ageing and degeneration of the intervertebral disc. [PDF]
, 2012 Despite the high prevalence of intervertebral disc disease, little is known about changes in intervertebral disc cells and their regenerative potential with ageing and intervertebral disc degeneration.
Alini, Mauro +14 more
core +2 more sources
eLife, 2020 The cell cycle regulator p16 is known as a biomarker and an effector of aging. However, its function in intervertebral disc degeneration (IVDD) is unclear.
Hui Che +11 more
semanticscholar +1 more source
Advanced Science, EarlyView.This study describes the creation of injectable Brachyury (Bry) mRNA‐loaded Fucoidan‐functionalized GelMA hydrogel microspheres (BLNP@GF). These microspheres efficiently suppress inflammation, enhance extracellular matrix (ECM) synthesis in degenerated nucleus pulposus cells, and mitigate intervertebral disc degeneration (IVDD) in rat models.
Yuhao Gong +12 more
wiley +1 more source
JOR Spine, 2018 Mechanical loading is inherently related to the function and degeneration of the intervertebral disc. We present a series of experiments aimed at measuring the effect of a loading/unloading cycle of the intervertebral disc on the mechanical properties of
Steven V. Beekmans +3 more
doaj +1 more source