Results 71 to 80 of about 18,919 (201)
BMC Musculoskeletal Disorders, 2011 Background The present study was conducted to address whether the intervertebral disc of rabbit could be considered (i) as a valuable model to provide new insights into the tissue and cellular changes of Nucleus pulposus aging and (ii) as an appropriate ...
Gauthier Olivier +11 more
doaj +1 more source
Complex Mechanical Loading and Pro‐Inflammatory Cytokines in Intervertebral Disc Degeneration
JOR SPINE, Volume 9, Issue 1, March 2026.This study investigated the combined effects of dynamic compression and torsion with major pro‐catabolic cytokine interleukin‐1 beta (IL‐1β) and its inhibitor: interleukin‐1 receptor antagonist (IL‐1Ra), on bovine IVD in an ex vivo organ culture system and further evaluated the mechanical effects using a subject‐personalized finite element model based ...
Katherine B. Crump +8 more
wiley +1 more source
Is Pain Blockage Safe? The Viewpoint Based on Nucleus Pulposus Cell Cytotoxicity [PDF]
, 2014 Sung Uk Kuh +3 more
openalex +1 more source
Versatile Cell Penetrating Peptide for Multimodal CRISPR Gene Editing in Primary Stem Cells
Advanced Functional Materials, Volume 36, Issue 5, 15 January 2026.CRISPR machinery in diverse molecular formats (DNA, RNA, and ribonucleic protein) is complexed into nanoparticles with the cell‐friendly arginine‐alanine‐leucine‐alanine (RALA) cell‐penetrating peptide. Nanoparticles are delivered to primary mesenchymal stem cells ex vivo or locally in vivo to facilitate multimodal CRISPR gene editing. This RALA‐CRISPR
Joshua P. Graham +9 more
wiley +1 more source
Granular Hydrogels as Modular Biomaterials: From Structural Design to Biological Responses
Advanced Healthcare Materials, Volume 15, Issue 3, 19 January 2026.Granular hydrogels are now emerging as promising biomaterials due to their inherent microporousity, injectability, and modularity. They have shown improvements in cell viability and migration, cellular/tissue infiltration, host tissue integration, mitigated foreign body response, and tissue regeneration.
Asmasadat Vaziri +6 more
wiley +1 more source
Ecotoxicology and Environmental SafetyThis study aimed to detect and characterize microplastics in intervertebral disc and investigate their effects and molecular mechanism on intervertebral disc degeneration.
Weilin Zhang +10 more
doaj +1 more source
Minimal Sustainability of Dedifferentiation by ROCK Inhibitor on Rat Nucleus Pulposus Cells In Vitro
Spine Surgery and Related Research, 2019 Introduction: Intervertebral disc degeneration is strongly associated with low back pain. Cell transplantation has been extensively studied as a treatment option for intervertebral disc degeneration. It is often necessary to perform cell culture prior to
Tadashi Nukaga +6 more
doaj +1 more source
Structural Interface Engineering Unlocks Native‐Like Mechanics in Biomimetic Intervertebral Discs
Advanced Materials Interfaces, Volume 13, Issue 1, 7 January 2026.Engineered interlamellar and radial fibrous interfaces enable biomimetic intervertebral disc constructs to replicate native mechanical behavior. Suture‐reinforced laminates enhance cohesion and shear strength, while radial fibers improve compressive resilience and stress redistribution.
Haim S. Mordechai +3 more
wiley +1 more source
Acidic pH promotes nucleus pulposus cell senescence through activating the p38 MAPK pathway [PDF]
, 2018 Jiabin Fu, Wei Yu, Dianming Jiang
openalex +1 more source