Results 71 to 80 of about 494,442 (303)

Single-cell RNA-seq analysis reveals the Wnt/Ca2+ signaling pathway with inflammation, apoptosis in nucleus pulposus degeneration

open access: yesBMC Musculoskeletal Disorders
Background Increasing studies have shown degeneration of nucleus pulposus cells (NPCs) as an critical part of the progression of intervertebral disc degeneration (IVDD).
Peigeng Wang, Zhencong Li, Dongping Ye
doaj   +1 more source

Sirt1 protects against intervertebral disc degeneration induced by 1,25-dihydroxyvitamin D insufficiency in mice by inhibiting the NF-κB inflammatory pathway

open access: yesJournal of Orthopaedic Translation, 2023
Background: It has been demonstrated that vitamin D deficiency is associated with an increased risk of patients developing lumbar disc herniation. However, intervertebral disc degeneration caused by active vitamin D deficiency has not been reported. Thus,
Peng Wang   +5 more
doaj  

Nucleus pulposus explant culture model [PDF]

open access: yesJournal of Orthopaedic Research, 2009
AbstractMany of the therapeutic interventions for intervertebral disc degeneration attempt to repopulate the nucleus pulposus (NP) tissue; however, NP cells are heterogeneous and not well characterized. To address this, we have investigated the morphology, extracellular gene and protein expression, and apoptosis changes in NP explants cultured in vitro
Gang Feng   +4 more
openaire   +3 more sources

Stiffness of photocrosslinkable gelatin hydrogel influences nucleus pulposus cell propertiesin vitro

open access: yesJournal of Cellular and Molecular Medicine, 2020
A key early sign of degenerative disc disease (DDD) is the loss of nucleus pulposus (NP) cells (NPCs). Accordingly, NPC transplantation is a treatment strategy for intervertebral disc (IVD) degeneration. However, in advanced DDD, due to structural damage
Panpan Xu   +8 more
semanticscholar   +1 more source

Biomimetic Glycosaminoglycan‐Analog Hydrogel for Improved Embolization of Aneurysms: Environment‐Selective Swelling

open access: yesAdvanced Healthcare Materials, EarlyView.
Biomimetic glycosaminoglycan analog hydrogels exhibit suitable and robust mechanical properties, as well as hemocompatibility and biocompatibility, making them ideal for the embolization of intracranial aneurysms. Notably, the hydrogel's environment‐selective swelling properties enable complete blockage of the aneurysm cavity while preventing ...
Sarit S. Sivan   +8 more
wiley   +1 more source

Nucleus-nucleus potential with shell-correction contribution [PDF]

open access: yes, 2015
The full relaxed-density potential between spherical nuclei is considered as a sum of the macroscopic and shell-correction contributions. The macroscopic part of the potential is related to a nucleus-nucleus potential obtained in the framework of the extended Thomas-Fermi approach with the Skyrme and Coulomb forces and the relaxed-density ansatz for ...
arxiv   +1 more source

Reconstructing the impact parameter of proton-nucleus and nucleus-nucleus collisions [PDF]

open access: yesPhys. Rev. C 98, 024902 (2018), 2018
In proton-nucleus and nucleus-nucleus collision experiments, one determines the centrality of a collision according to the multiplicity or energy deposited in a detector. This serves as a proxy for the true collision centrality, as defined by the impact parameter.
arxiv   +1 more source

p16 deficiency attenuates intervertebral disc degeneration by adjusting oxidative stress and nucleus pulposus cell cycle

open access: yeseLife, 2020
The cell cycle regulator p16 is known as a biomarker and an effector of aging. However, its function in intervertebral disc degeneration (IVDD) is unclear.
Hui Che   +11 more
semanticscholar   +1 more source

From Mechanoelectric Conversion to Tissue Regeneration: Translational Progress in Piezoelectric Materials

open access: yesAdvanced Materials, EarlyView.
This review highlights recent progress in piezoelectric materials for regenerative medicine, emphasizing their ability to convert mechanical stimuli into bioelectric signals that promote tissue repair. Key discussions cover the intrinsic piezoelectric properties of biological tissues, co‐stimulation cellular mechanisms for tissue regeneration, and ...
Xinyu Wang   +3 more
wiley   +1 more source

Dynamic behavior of the nucleus pulposus within the intervertebral disc loading: a systematic review and meta-analysis exploring the concept of dynamic disc model

open access: yesFrontiers in Bioengineering and Biotechnology
IntroductionThe dynamic disc model (DDM) is a theoretical framework in spine mechanics that theorizes the behavior of the nucleus pulposus within the intervertebral disc under various loads.
Jean-Philippe Deneuville   +23 more
doaj   +1 more source

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