Results 81 to 90 of about 18,919 (201)

PACS‐2 Mitigates NPSC Apoptosis and Intervertebral Disc Degeneration by Preserving MAM Integrity via the SP1/LRRK2/Mfn2 Axis

Advanced Science, Volume 13, Issue 4, 19 January 2026.
This study investigates the role of PACS‐2 in IDD, demonstrating that it suppresses the nuclear translocation of SP1, thereby downregulating its downstream target LRRK2. This reduces LRRK2‐mediated ubiquitination and degradation of Mfn2 through the JNK pathway, preserving MAM integrity and promoting NPSC survival.
Liang Kang, Jiaqi Wang, Chenhao Zhao, Qiuwei Li, Zhigang Zhang, Huaqing Zhang, Chongyu Jia, Luping Zhou, Yanxin Wang, Yu Chen, Kaixuan Li, Xu Yan, Jie Fang, Haibao Wang, Dandan Wang, Pingping Su, Jingyu Zhang, Zhiwei Chen, Renjie Zhang, Cailiang Shen   +19 more
wiley   +1 more source

Acidic and basic self-assembling peptide and peptide-graphene oxide hydrogels: characterisation and effect on encapsulated nucleus pulposus cells

, 2022
Cosimo Ligorio, Aravind Vijayaraghavan, Judith A. Hoyland, Alberto Saiani   +3 more
openalex   +1 more source

Exosome‐Based Cartilage‐Targeted Delivery System: Strategies and Applications

Small Science, Volume 6, Issue 1, January 2026.
Construction strategies and applications of cartilage‐targeting exosomes. With the ageing of the global population, cartilage‐related diseases, such as osteoarthritis (OA) and intervertebral disc degeneration (IVDD), have increasingly become significant social problems threatening human health. Therefore, targeted therapy for cartilage is becoming more
Yao Wang, Bo Chen, Haodong Zhu, Zhenyu Sun   +3 more
wiley   +1 more source

Hydrogel Microspheres for Biomedical Applications

Small Science, Volume 6, Issue 1, January 2026.
Hydrogel microspheres (HMs) play pivotal roles in biomedical applications, such as drug delivery, cell culture, regenerative medicine, wound healing, and tumor immunity. This review focuses on the latest findings to provide a more comprehensive understanding of HMs for biomedical applications.
Yingkang Huang, Xi Zhu, Jinhong Zhou, Henan Li, Wei Zhang, Danyang Shen, Ziyan Huang, Tianbo Zhang, Lin Zhuang, Lei Qin, Xiaofeng Xue, Yunjie Lu   +11 more
wiley   +1 more source

Bone-derived mesenchymal stem cells alleviate compression-induced apoptosis of nucleus pulposus cells by N6 methyladenosine of autophagy [PDF]

, 2020
Gaocai Li, Yu Song, Zhiwei Liao, Kun Wang, Rongjin Luo, Saideng Lu, Kangcheng Zhao, Xiaobo Feng, Hang Liang, Liang Ma, Bingjin Wang, Wencan Ke, Huipeng Yin, Shengfeng Zhan, Shuai Li, Xinghuo Wu, Yukun Zhang, Yang Cao   +17 more
openalex   +1 more source

Correction to “The Research of Transgenic Human Nucleus Pulposus Cell Transplantation in the Treatment of Lumbar Disc Degeneration”

The Kaohsiung Journal of Medical Sciences, EarlyView.
wiley   +1 more source

Leptin Regulates Intervertebral Disc Calcification and Ossification by Promoting Glycolysis Through OCN/HIF‐1α Axis

Journal of Cellular and Molecular Medicine, Volume 30, Issue 1, January 2026.
ABSTRACT During intervertebral disc degeneration (IDD), cartilage endplate (CEP) cells undergo calcification and ossification, relying primarily on glycolysis for energy metabolism. Leptin (LEP) initiates the IDD, while its underlying mechanism related to glycolysis remains elusive in CEP cells. To investigate the underlying mechanism of LEP on IDD, an
Haoxi Li, Chengqiang Yu, Zhuhai Li, Shuyu Yao, Kaiqi Mo, Guanlu Peng, Yufeng Huang, Jianxun Wei   +7 more
wiley   +1 more source

Transcriptomic and Functional Comparison of Cells Isolated From Healthy and Degenerated Ovine Intervertebral Discs

Journal of Cellular and Molecular Medicine, Volume 30, Issue 2, January 2026.
ABSTRACT Intervertebral disc degeneration (IVDD) is a leading cause of chronic low back pain, yet its cellular and molecular mechanisms remain incompletely understood. Sheep represent a valuable in vivo and ex vivo model for IVDD due to their anatomical and biomechanical similarities with humans and the possibility to access disc samples at early ...
Paul Humbert, Lucie Danet, Emmaëlle Carrot, Floriane Etienne, Boris Halgand, Frédéric Blanchard, Claire Vinatier, Jérôme Guicheux, Marion Fusellier, Catherine Le Visage, Romain Guiho   +10 more
wiley   +1 more source

Mitochondrial DNA induces nucleus pulposus cell pyroptosis via the TLR9-NF-κB-NLRP3 axis [PDF]

, 2023
Lü Peng, Huayong Zheng, Hao Meng, Chuan Liu, Lianhong Duan, Jianzheng Zhang, Zhicheng Zhang, Jie Gao, Yang Zhang, Tiansheng Sun   +9 more
openalex   +1 more source

Progress of Programmed Cell Death in Steroid‐Induced Osteonecrosis of the Femoral Head

Orthopaedic Surgery, Volume 18, Issue 1, Page 16-30, January 2026.
Steroid‐induced osteonecrosis of the femoral head is a severe osteoarticular condition resulting from glucocorticoid overuse, characterized by femoral head bone structure collapse and cell death, now predominant among nontraumatic femoral head necroses.
Zhi Kong, Chao Han
wiley   +1 more source