Results 81 to 90 of about 18,806 (262)

Quality Assessment of Surgical Disc Samples Discriminates Human Annulus Fibrosus and Nucleus Pulposus on Tissue and Molecular Level [PDF]

, 2018
Ann-Kathrin Schubert, Jeske J. Smink, Mirko Arp, Jochen Ringe, Aldemar Andrés Hegewald, Michael Sittinger   +5 more
openalex   +1 more source

Biomimetic Glycosaminoglycan Analog Hydrogels Inhibit Neurite Outgrowth While Supporting Neuronal Cell Viability

Journal of Biomedical Materials Research Part A, Volume 113, Issue 12, December 2025.
ABSTRACT Intervertebral disc (IVD) degeneration is a leading contributor to chronic low back pain, imposing a substantial global burden. Native IVD tissue relies on sulfated glycosaminoglycans (sGAG) to maintain hydration and mechanical function through fixed negative charges and associated osmotic pressure.
Khyal Sumaya, Dar Segev, Haim S. Mordechai, Malka Shilo, Mirit Sharabi, Sarit S. Sivan   +5 more
wiley   +1 more source

Minimal Sustainability of Dedifferentiation by ROCK Inhibitor on Rat Nucleus Pulposus Cells In Vitro

Spine Surgery and Related Research, 2019
Introduction: Intervertebral disc degeneration is strongly associated with low back pain. Cell transplantation has been extensively studied as a treatment option for intervertebral disc degeneration. It is often necessary to perform cell culture prior to
Tadashi Nukaga, Daisuke Sakai, Jordy Schol, Kaori Suyama, Tomoko Nakai, Akihiko Hiyama, Masahiko Watanabe   +6 more
doaj   +1 more source

Automated Computational Pathology to Assess Degenerative Disc Histology

JOR SPINE, Volume 8, Issue 4, December 2025.
We utilized human‐in‐the‐loop active learning methods (1) to develop the first computational pathology model to segment disc tissue (2). These segmentation outputs were used to derive shape and other measures to phenotype disc pathology which were correlated with histological scoring but also provides increased sensitivity to detect differences (3 ...
Richard D. Bell, Evie C. Reddick, David J. Lillyman, Fei San Lee, Rebecca A. Wachs   +4 more
wiley   +1 more source

Vertebral Growth Modulation Through Periosteal Resection and Fixed Length Deformity Overcorrection: Computational and In Vivo Pilot Study

JOR SPINE, Volume 8, Issue 4, December 2025.
The feasibility of using growth promoting strategies (vertebral periosteal resection and distraction) was investigated via computational and in vivo analysis. Computational analysis demonstrated that there is an increasing mechanical benefit to utilizing concave distraction over convex compression during spinal deformity correction.
Matthew A. Halanski, Cameron Jeffers, Yousuf Abubakr, Minhao Zhou, Brittney Kokinos, Max Twedt, David Bennett, Susan Hamman, Thomas Crenshaw, Grace D. O'Connell, Hani Haider   +10 more
wiley   +1 more source

Epidural injection of cyclooxygenase‐2 inhibitor attenuates pain‐related behavior following application of nucleus pulposus to the nerve root in the rat [PDF]

, 2002
Mamoru Kawakami, Takuji Matsumoto, Hiroshi Hashizume, Koichi Kuribayashi, Tetsuya Tamaki   +4 more
openalex   +1 more source

Age and Spinal Level as Predictors of Lumbar Disc Degeneration in Humans and Mice: A Comparative Analysis

JOR SPINE, Volume 8, Issue 4, December 2025.
Mouse models are commonly used to study IVD degeneration and related neurological conditions that especially impact elder population. However, how well mice replicate human pathology remains unclear. This study compared lumbar IVD degeneration patterns across age and spinal levels in humans and mice.
Ravij Mehta, Sarthak Mohanty, Andrew Parker Hallmark, Veeraj Shah, Tom Ross, Eric A. Bogner, Tejbir S. Pannu, Mathieu Bannwarth, Sohrab Virk, Sravisht Iyer, James C. Farmer, Russel C. Huang, Darren R. Lebl, Bernard A. Rawlins, Harvinder S. Sandhu, Han Jo Kim, Matthew E. Cunningham, Sheeraz Qureshi, Todd J. Albert, Chitra L. Dahia   +19 more
wiley   +1 more source

Reduced Shear Modulus and Altered Lamellar Morphology of the Outer Annulus Fibrosus in Painful Intervertebral Disc Degeneration Compared With Tissue From Non‐Surgical Controls

JOR SPINE, Volume 8, Issue 4, December 2025.
Disc degeneration (DD) results in a mechanically dysfunctional disc through progressive loss of the intervertebral disc's (IVD) highly organized structure. This study measured shear and structure properties of the outer annulus fibrosus in surgical DD and minimally degenerative (non‐DD) donor individuals.
Taylor J. Bader, Manmeet Dhiman, Lucas Lo Vercio, Jacques Bouchard, Fred Nicholls, Nathan Evaniew, Bradley Jacobs, Kenneth C. Thomas, Paul Salo, David A. Hart, Neil A. Duncan, Ganesh Swamy   +11 more
wiley   +1 more source

High‐Resolution 3‐Dimensional Micro‐CT Imaging of Intervertebral Discs Using a Novel Contrast Agent

JOR SPINE, Volume 8, Issue 4, December 2025.
This study introduces the first use of a contrast agent (potassium iodide) to enhance 3D imaging of the nucleus pulposus within an intact intervertebral disc (IVD). This method was used to demonstrate consistent 3D imaging of the nucleus pulposus across multiple animal models, including spine and tail IVDs.
Madison M. Buckles, Abdulkadir Nur, Nada H. Warda, Jacob C. Moncher, Mohammad Yunus Ansari   +4 more
wiley   +1 more source

Lactate Metabolism in Intervertebral Disc Degeneration: Unveiling Novel Mechanisms Through Bioinformatics

JOR SPINE, Volume 8, Issue 4, December 2025.
This graphical abstract outlines the workflow to uncovering lactate metabolism‐related mechanisms in intervertebral disc degeneration (IDD). First, three IDD datasets (GSE34095: 3 IDD vs 3 control; GSE147383: 2 IDD vs 2 control; GSE70362: 16 IDD vs 8 control) were sourced from the Gene Expression Omnibus (GEO) database, and 73 lactate metabolism ...
Haiyan Sun, Mingwei He, Jinlei Pang, Xiangfei Guo, Yansong Huo, Jun Ma   +5 more
wiley   +1 more source