Results 81 to 90 of about 473,018 (289)

Anisodamine Maintains the Stability of Intervertebral Disc Tissue by Inhibiting the Senescence of Nucleus Pulposus Cells and Degradation of Extracellular Matrix via Interleukin-6/Janus Kinases/Signal Transducer and Activator of Transcription 3 Pathway

Frontiers in Pharmacology, 2020
Objectives: Anisodamine (ANI) has been used to treat a variety of diseases. However, the study of ANI in intervertebral disc degeneration (IVDD) is unclear. This study investigated the effects of ANI on degenerative nucleus pulposus cells (NPCs) and IVDD
Ning Tang, Yu-lei Dong, Chong Chen, Hong Zhao   +3 more
semanticscholar   +1 more source

Immunomodulatory Biomaterials for Bone and Soft Tissue Chronic Inflammation Diseases

Small Science, EarlyView.
This review analyzes immunomodulatory biomaterial strategies for treating chronic inflammatory disorders in bone and soft tissues. It explores emerging mechanisms for resolving inflammation while promoting tissue regeneration, offering insights for developing targeted immunotherapeutic approaches that bridge material science with immunology for ...
Yiming Li, Xudong Xie, Chong Ding, Shengming Zhang, Liangcong Hu, Bobin Mi, Mengfei Liu, Guohui Liu   +7 more
wiley   +1 more source

Inhibition of the P53/P21 Pathway Attenuates the Effects of Senescent Nucleus Pulposus Cell‐Derived Exosomes on the Senescence of Nucleus Pulposus Cells

Orthopaedic Surgery, 2020
The purpose of this paper is to investigate the effects of senescent nucleus pulposus cell (NPC)‐derived exosomes (SNPC‐Exo) and the roles of the P53/P21 pathway on the senescence of NPC.
Chang-Chun Chen, J. Chen, Wen-Liang Wang, L. Xie, Chuan-Qiang Shao, Yan-Xiang Zhang   +5 more
semanticscholar   +1 more source

Mechanosensitive Cell‐Laden Shape‐Memory Scaffolds Engineered via Cryogelation

Small Structures, EarlyView.
GelMA‐based shape‐memory scaffolds encapsulating human adipose‐derived stem cells are fabricated via cryogelation, showing rapid recovery and high cell viability. Under cyclic compression, they promoted mechanotransduction gene expression, and composite formulations (collagen/GelMA, dECM/GelMA) retained robust shape‐memory, highlighting their promise ...
JaeYoon Lee, ByungJoon Choi, Hanjun Hwangbo, GaEun Heo, GeunHyung Kim   +4 more
wiley   +1 more source

Mitigating Pro‐Inflammatory SASP and DAMP With Urolithin A: A Novel Senomorphic Strategy

Aging Cell, EarlyView.
Senescent cells accumulate extranuclear DNA fragments that are recognized by the cyclic GMP‐AMP synthase (cGAS) and its effector protein stimulator of interferon genes (STING), which promotes expression of SASP and DAMP genes by inducing nuclear factor‐kappa B (NF‐κB) and IFN regulatory factor 3 (IRF3) translocation.
Anna Barkovskaya, Ashley Brauning, Aditi Thambala, Kriti Bhardwaj, Manish Chamoli, Anand Rane, Julie K. Andersen, Amit Sharma   +7 more
wiley   +1 more source

Intervertebral Disc Degeneration and Regeneration: New Molecular Mechanisms and Therapeutics

Cells
The intervertebral disc (IVD) is a soft tissue that constitutes the spinal column together with the vertebrae, and consists of the central nucleus pulposus (gelatinous tissue) and the annulus fibrosus (rich in fibrous tissue) that surrounds the nucleus ...
Hideki Sudo
doaj   +1 more source

Comparison of Adjacent Segment Degeneration After Nonrigid Fixation System and Posterior Lumbar Interbody Fusion for Single-Level Lumbar Disc Herniation: A New Method of MRI Analysis of Lumbar Nucleus Pulposus Volume

Journal of Investigative Surgery, 2018
Purpose: To evaluate the influence of a nonrigid fixation system and posterior lumbar interbody fusion on adjacent intervertebral disc degeneration by using MRI analysis of lumbar nucleus pulposus volume for single-level lumbar disc herniation. Materials
Shaofeng Yang, Yanan Liu, Zhaohua Bao, Jun Zou, Huilin Yang   +4 more
doaj   +1 more source

Oxymatrine suppresses IL-1β-induced degradation of the nucleus pulposus cell and extracellular matrix through the TLR4/NF-κB signaling pathway

Experimental biology and medicine, 2020
Intervertebral disc degeneration is the main cause of low back pain. However, its pathomechanism has not been fully clarified yet. Previous studies have indicated that inflammation may lead to apoptosis of nucleus pulposus cells and break the balance ...
K. Wei, Jun Dai, Zheng-gang Wang, Yaping Pei, Yan Chen, Yifan Ding, Qing Ding, Paerxiati Ahati, Xiaozhong Zhou, Huan Wang, Huang Fang   +10 more
semanticscholar   +1 more source

Dual‐Lineage Chondrocyte‐Like Cells in the Nucleus Pulposus of Aging Intervertebral Discs Are Accelerated by Hedgehog Signaling Inactivation

Aging Cell, EarlyView.
During intervertebral disc degeneration, notochord‐derived nucleus pulposus cells progressively transdifferentiate into Krt19+ chondrocyte‐like cells (CLCs) and Krt19− CLCs, which are eventually replaced by Krt19− CLCs from non‐notochordal Gli1+ progenitors.
Lei Zhang, Chunmei Xiu, Hongji You, Jianquan Chen   +3 more
wiley   +1 more source

Fibro-NPC: a pathogenic subtype identified at single-cell resolution with secreted SFRP4 as a biomarker in intervertebral disc degeneration

Journal of Translational Medicine
Background Intervertebral disc degeneration (IDD) is a primary cause of low back pain and, in severe cases, can lead to disability. Current treatments for low back pain remain limited in efficacy, underscoring the need for a deeper understanding of the ...
Yili Xu, Zuozhi Xie, Shubo Gu, Xiang Zhao, Di Zhao, Zhengzheng Wu, Jinfeng Wang, Tao Xu, Ruxue Xu, Zhenhua Feng, Yong Qiu, Zezhang Zhu, Yang Yu, Bo Shi, Jun Jiang   +14 more
doaj   +1 more source