Results 131 to 140 of about 4,980,963 (235)

Novel Flavonoid Senotherapeutics Identified by Phenotypic Drug Discovery Reduce Senescence and Improve Multiple Markers of Healthspan

Aging Cell, Volume 25, Issue 10, October 2026.
Phenotypic screening and SAR‐guided drug design identified two flavonoid‐derived senolytics, SR29384 and SR31133, which selectively killed different types of senescent cells more efficiently and with greater selectivity than fisetin in culture. In aged and progeroid mice, these fisetin analogs reduced tissue senescence and improved physical function ...
Lei Justan Zhang, Rahagir Salekeen, Carolina Soto‐Palma, Qiuming Wu, Yuanjun He, Osama Elsallabi, Bilel Bdiri, Brian Hughes, Allancer Nunes, Wandi Xu, Borui Zhang, Abdalla Mohamed, Sara J. McGowan, Luise Angelini, Ryan O'Kelly, Theodore M. Kamenecka, Laura J. Niedernhofer, Paul D. Robbins   +17 more
wiley   +1 more source

Decellularized nucleus pulposus matrix/chitosan hybrid hydrogel combined with nucleus pulposus stem cells and GDF5-loaded microspheres for intervertebral disc degeneration prevention

Molecular Medicine
Background Intervertebral disc degeneration (IDD) is considered an important pathological basis for spinal degenerative diseases. Tissue engineering is a powerful therapeutic strategy that can effectively restore the normal biological properties of disc ...
Tao Ma, Chen Liu, Quanlai Zhao, Yu Zhang, Liang Xiao   +4 more
doaj   +1 more source

β‐Catenin‐Deficient Intervertebral Disc Cells Reduce Chemotactic Transcription and Myeloid Cell Recruitment to Injured Discs of Mice

Aging Cell, Volume 25, Issue 10, October 2026.
(Left) In young discs, Wnt signaling‐replete nucleus pulposus cells secrete ECM components and, upon disc injury, cytokines to recruit myeloid cells. (Right) Whereas, β‐catenin‐deficient disc cells, modeling age‐related absence of Wnt signaling, exhibit reduced anabolic activity and, upon disc injury, secrete fewer pro‐inflammatory cytokines and ...
Tori M. Kroon, Jazz Munitz, Anna Ranzenigo, Martin Umali, William Wang, Jonathan J. Huang, Abraham J. P. Teunissen, Nilsson Holguin   +7 more
wiley   +1 more source

ZNF865 (BLST) a Novel Regulator of DNA Damage and Cell Senescence in Back Pain

Aging Cell, Volume 25, Issue 10, October 2026.
ZNF865 (BLST) has previously been classified as part of the “unknome”, but here in the context of back pain, we demonstrate the first functional characterization of ZNF865. We demonstrate that it regulates genomic stability and subsequent senescence, and that downregulation in the intervertebral disc leads to pain behavior in rodent models.
Christian Lewis, Hunter Levis, Jonah Holbrook, Jacob T. Polaski, Timothy D. Jacobsen, Josh Mizels, Molly Czachor, Sarah E. Gullbrand, Brian Diekman, James C. Iatridis, Jason Gertz, Brandon Lawrence, Robby D. Bowles   +12 more
wiley   +1 more source

Characterization of the Nucleus Pulposus Progenitor Cells via Spatial Transcriptomics

Advanced Science
AbstractLoss of refreshment in nucleus pulposus (NP) cellularity leads to intervertebral disc (IVD) degeneration. Nevertheless, the cellular sequence of NP cell differentiation remains unclear, although an increasing body of literature has identified markers of NP progenitor cells (NPPCs).
Yu Chen, Long Zhang, Xueqing Shi, Jie Han, Jingyu Chen, Xinya Zhang, Danlin Xie, Zan Li, Xing Niu, Lijie Chen, Chaoyong Yang, Xiujie Sun, Taifeng Zhou, Peiqiang Su, Na Li, Matthew B. Greenblatt, Rongqin Ke, Jianming Huang, Zhe‐Sheng Chen, Ren Xu   +19 more
openaire   +3 more sources

Neferine alleviates intervertebral disc degeneration through KEAP1/NRF2/GPX4 and NF-κB signaling pathways

Shanghai Jiaotong Daxue xuebao. Yixue ban
Objective·To investigate the therapeutic effects of neferine (Nef) on intervertebral disc degeneration (IDD) and the underlying regulatory pathways.Methods·The effects of Nef on the viability and proliferation of nucleus pulposus cells were assessed ...
WAN Hongjin, HU Yibin, WANG Xin, ZHANG Kai, QIN An, MA Peixiang, MA Hui, ZHAO Jie   +7 more
doaj   +1 more source

Mini‐Open Versus Open Transforaminal Lumbar Interbody Fusion in Patients Aged ≥ 75 Years: Perioperative Surgical Burden and Clinical Outcomes

Orthopaedic Surgery, Volume 18, Issue 10, Page 2090-2100, October 2026.
In 172 patients aged ≥ 75 years undergoing TLIF, mini‐open TLIF (MO‐TLIF) reduced perioperative burden (shorter operative time, less blood loss, lower POD3 CK) and enabled faster early pain/function recovery versus open TLIF, while 3–6 month PROMs and 12‐month fusion and satisfaction were comparable.
Zhendong Huang, Kelv Shen, Fengxian Jiang, Fengyu Ma, Xiang Wang, Hui Wang, Zhengfeng Lu   +6 more
wiley   +1 more source

Orthopedic Mechanophenotype: A Structured Narrative Review of Multiscale Biomechanics, Mechanotransduction, and Clinical Decision‐Making

Orthopaedic Surgery, Volume 18, Issue 10, Page 2045-2059, October 2026.
The orthopedic mechanophenotype framework comprises load exposure, tissue susceptibility, and biological adaptability axes to decode mechanical‐biological crosstalk. It guides clinical phenotyping, targeted intervention, and response monitoring for orthopedic disorders beyond static morphological assessment.
Zihao Lan, Zhipeng Mu, Hongjian Li
wiley   +1 more source

Nucleus pulposus-induced apoptosis in dorsal root ganglion following experimental disc herniation in rats

, 2006
STUDY DESIGN: The mechanisms behind the formation of a characteristic tissue reaction at the surface of the dorsal root ganglion (DRG) exposed to nucleus pulposus was studied with special reference to apoptosis using electron microscopy and ...
Murata, Y., Rydevik, Björn,, Nannmark, Ulf,, Takahashi, K., Olmarker, Kjell,   +4 more
core  

In vitro analysis of osteogenic inhibition in non-union spinal fusion caused by nucleus pulposus cells.

, 2015
Discectomy and spinal fusion is the gold standard for spinal surgery to relieve pain. However, fusion can be hindered for yet unknown reasons that lead to non-fusions with pseudo-arthrosis.
Gantenbein, Benjamin, Chan, Samantha, Frauchiger, Daniela Angelika, Heini, Paul Ferdinand, Tekari, Adel, Benneker, Lorin Michael   +5 more
core