Results 111 to 120 of about 12,120 (223)

The biology of the ovine functional spinal unit: facet cartilage and intervertebral disc [PDF]

, 2013
Back pain will affect up to 84 % of people at some point in their lives. It is a major public health problem in Western society leading to disability and economic loss through work absence, physician visits and hospitalisation.
Gough, Caroline Shanni
core  

Creation of an injectable in situ gelling native extracellular matrix for nucleus pulposus tissue engineering

, 2017
Background Context: Disc degeneration is the leading cause of low back pain and is often characterized by a loss of disc height, resulting from cleavage of chondroitin sulfate proteoglycans (CSPGs) present in the nucleus pulposus.
Huda, Hammad I., Rebecca A. Wachs, Christine E. Schmidt, Porvasnik, Stacy L., Wachs, Rebecca A., Hoogenboezem, Ella N., Stacy L. Porvasnik, Hammad I. Huda, Xin, Shangjing, Schmidt, Christine E., Shangjing Xin, Ella N. Hoogenboezem   +11 more
core   +1 more source

Decellularized nucleus pulposus matrix/chitosan hybrid hydrogel combined with nucleus pulposus stem cells and GDF5-loaded microspheres for intervertebral disc degeneration prevention

Molecular Medicine
Background Intervertebral disc degeneration (IDD) is considered an important pathological basis for spinal degenerative diseases. Tissue engineering is a powerful therapeutic strategy that can effectively restore the normal biological properties of disc ...
Tao Ma, Chen Liu, Quanlai Zhao, Yu Zhang, Liang Xiao   +4 more
doaj   +1 more source

Neferine alleviates intervertebral disc degeneration through KEAP1/NRF2/GPX4 and NF-κB signaling pathways

Shanghai Jiaotong Daxue xuebao. Yixue ban
Objective·To investigate the therapeutic effects of neferine (Nef) on intervertebral disc degeneration (IDD) and the underlying regulatory pathways.Methods·The effects of Nef on the viability and proliferation of nucleus pulposus cells were assessed ...
WAN Hongjin, HU Yibin, WANG Xin, ZHANG Kai, QIN An, MA Peixiang, MA Hui, ZHAO Jie   +7 more
doaj   +1 more source

Difference in Energy Metabolism of Annulus Fibrosus and Nucleus Pulposus Cells of the Intervertebral Disc

, 2011
Low back pain is associated with intervertebral disc degeneration. One of the main signs of degeneration is the inability to maintain extracellular matrix integrity.
Wei Yong Gu, Jessica Czamanski Salvatierra, Fernando, Hanan, Andre Castillo, Herman S. Cheung, Cheung, Herman S, C.-Y. Charles Huang, Yuan, Tai Yi, Castillo, Andre, Tai Yi Yuan, Salvatierra, Jessica Czamanski, Huant, C.-Y. Charles, Gu, Wei Yong, Hanan Fernando   +13 more
core   +1 more source

The Roles of MAPKs in Rabbit Nucleus Pulposus Cell Apoptosis Induced by High Osmolality

Global Spine Journal, 2014
Introduction Earlier work has suggested that the p38 MAPK, JNK1/2, and ERK1/2 signal pathway existed in nucleus pulposus cells and the cell growth, differentiation, and apoptosis were regulated by them.
D. Wang, Fanghui Li, Ruilong Liu, Jianwei Wei, Chuanli Zhou   +4 more
doaj   +1 more source

Nucleus pulposus cellular longevity by telomerase gene therapy

, 2007
Study designNonviral transfection of nucleus pulposus cells with a telomerase expression construct to assess the effects on cellular lifespan, function, karyotypic stability, and transformation properties.ObjectivesTo investigate whether telomerase gene ...
Webb, Graham, Connor, David, Chung, S., Chung, Sylvia, Wei, A., Molloy, T., Molloy, Tim, Wei, Ai-Qun, Pajic, Marina, Connor, D., Pajic, M., Diwan, A., Webb, G., Diwan, Ashish   +13 more
core   +1 more source

Effect of acupotomy intervention on the expressions of proteoglycans in lumbar intervertebral disc of rabbits with lumbar intervertebral disc degeneration

针刺研究, 2023
Objective To observe the effect of acupotomy intervention on the expressions of biglycan(BGN), decorin(DCN) and Caspase-3 in lumbar intervertebral disc of rabbits with lumbar intervertebral disc degeneration(LIDD), so as to explore its possible mechanism
HU Jiang-shan, TANG Hong-tu, YAN Jing, LI Yi-hong, HU Xia, LI Jia, WANG Hua   +6 more
doaj  

Investigations to the adenoliposomalen genetic transfer in human Nucleus pulposus cells from degenerated intervertebral disc

, 2010
Wirbelsäulen assoziierte Erkrankungen, speziell discogener Genese, sind ein sozioökonomisches Problem, da sie zu den häufigsten Gründen von Arbeitsausfällen und vorzeitigen Berentungen zählen.
Just, Katleen
core   +1 more source

Injectable ECM-mimetic dynamic hydrogels abolish ferroptosis-induced post-discectomy herniation through delivering nucleus pulposus progenitor cell-derived exosomes

Nature Communications
Discectomy-induced ferroptosis of nucleus pulposus cells (NPCs) contributes to postoperative lumbar disc herniation (LDH) recurrence and intervertebral disc degeneration (IDD).
Wenkai Wang, Zhuo Cheng, Miao Yu, Ke Liu, Hongli Duan, Yang Zhang, Xinle Huang, Menghuan Li, Changqing Li, Yan Hu, Zhong Luo, Minghan Liu   +11 more
doaj   +1 more source