Results 101 to 110 of about 4,980,963 (235)

Increased HIF-2α activity in the nucleus pulposus causes intervertebral disc degeneration in the aging mouse spine [PDF]

Hypoxia-inducible factors (HIFs) are essential to the homeostasis of hypoxic tissues. Although HIF-2α, is expressed in nucleus pulposus (NP) cells, consequences of elevated HIF-2 activity on disc health remains unknown.
Tsingas, Maria, Ain, Rahatul, Risbud, Makarand V, Barve, Ruteja A, Johnston, Shira N   +4 more
core   +1 more source

Tracing notochord-derived cells using a Noto-cre mouse: implications for intervertebral disc development

Disease Models & Mechanisms, 2012
SUMMARY Back pain related to intervertebral disc degeneration is the most common musculoskeletal problem, with a lifetime prevalence of 82%. The lack of effective treatment for this widespread problem is directly related to our limited understanding of ...
Matthew R. McCann, Owen J. Tamplin, Janet Rossant, Cheryle A. Séguin   +3 more
doaj   +1 more source

Macrophage Lipid Homeostasis Drives IVDD via a Senescence‐Dependent Impairment of Efferocytosis

Cell Proliferation, EarlyView.
Intervertebral disc degeneration (IVDD) has been a leading cause of low back pain and lacks disease‐modifying therapies. Although dysregulated disc lipid metabolism is implicated, its impact on the immune microenvironment, particularly macrophages, remains unknown.
Jinyu Wang, Shiyong Ling, Qi Wang, Xuege Qiao, Jianpeng Xing, Siyang Ji, Linhui Han, Chen Yan, Zhishen Niu, Lei Yuan, Baolian Zhao, Kaiqiang Sun, Jiangang Shi   +12 more
wiley   +1 more source

The differentiation of annulus fibrosus and nucleus pulposus.

, 2020
(a) The annulus fibrosus, (b) The nucleus pulposus.
Hongxin Zhang (551048), Qian Wang (32718), Yuedan Li (8496018), Ning Liang (3777817), Jing Li (10611), Qian Huang (127640), Tao Yang (184280), Yi Yang (116183), Wei Cao (50866), Renzhi Li (1630813)   +9 more
core   +1 more source

The enigma that is the nucleus pulposus cell: the search goes on [PDF]

Arthritis Research & Therapy, 2010
The development of an effective treatment for degenerative disc disease has been hampered for many years by what seems a fundamental problem; what exactly defines a nucleus pulposus (NP) cell? The paper by Gilson and colleagues elegantly re-opens the debate concerning the lineage and identity of NP cells that are alike yet different from chondrocytes ...
openaire   +1 more source

Effects of zinc finger protein A20 over-expression on inflammatory response and degeneration of human intervertebral disc nucleus pulposus cells stimulated with lipopolysaccharide

Di-san junyi daxue xuebao, 2019
Objective To observe the effects of zinc finger protein A20 over-expression on the expression of inflammatory cytokines and nuclear factor-κB (NF-κB) in human intervertebral disc nucleus pulposus cells and on cell degeneration in response to ...
LAN Haiyang, YANG Zhijie, XIA Huiqiang, CHEN Jie, LIU Bo   +4 more
doaj   +1 more source

Ammonia Accumulation Drives Intervertebral Disc Degeneration by Triggering Ammonia‐Induced Cell Death Through Lysosome–Mitochondria Crosstalk

Cell Proliferation, EarlyView.
Mechanical strain disrupts the lysosome‐mitochondria axis via GLS1‐mediated ammonia toxicity, causing NP cell death and ECM breakdown in IVDD. CB839‐mediated GLS1 inhibition effectively rescues cellular homeostasis and alleviates disc degeneration.
Yang Zhang, Yucheng Gao, Shuhang Dong, Shuanggong Liu, Lei Liu, Ziyi Song, Jie Xu, Yijun Rong, Guangxu Song, Yingze Zhang, Dongjin Wu, Zengxin Gao   +11 more
wiley   +1 more source

Gram positive bacteria within the intervertebral disc and their potential influence on nucleus pulposus cells [PDF]

, 2023
Introduction Modic changes (MC) that are vertebral bone marrow lesions visualised on magnetic resonance imaging have been associated with disc degeneration. For MC type I one of the identified aetiologies is infection of the intervertebral disc (IVD) [
Lacey, Melissa, Gantenbein, Benjamin, Alexopoulus, Leonidas, Nüesch, Andrea, Kanelis, Exarchos, Breakwell, Lee, Le Maitre, Christine, Williams, Frances   +7 more
core  

Overexpression of microRNA-185 alleviates intervertebral disc degeneration through inactivation of the Wnt/-catenin signaling pathway and downregulation of Galectin-3

Molecular Pain, 2020
Background Recent studies have found that microRNAs (miRNAs) play a critical role in development and progression of intervertebral disc degeneration. In the present study, we examined the role of miR-185 in nucleus pulposus cell behavior in vitro and the
Zhennan Yun, Yuhang Wang, Wei Feng, Junting Zang, Daguang Zhang, Yuhang Gao   +5 more
doaj   +1 more source

From senescence and inflammaging to systemic comorbidities: Drivers of aging‐associated periodontitis

Periodontology 2000, EarlyView.
Abstract Background Aging is accompanied by a chronic low‐grade inflammatory process, known as inflammaging, as well as immunosenescence, an age‐related decline and dysregulation of immune function, and cellular senescence, a process in which cells enter a state of irreversible growth arrest while actively releasing pro‐inflammatory factors.
James Cheng, Chew Tin Zar Aung, Samuel F. Suslavich, Sinem Esra Sahingur, Yvonne L. Hernandez‐Kapila   +4 more
wiley   +1 more source