Results 81 to 90 of about 12,120 (223)

Acidification changes affect the inflammasome in human nucleus pulposus cells [PDF]

Journal of Inflammation, 2016
Interleukin (IL)-1β is involved in the pathology of intervertebral disc degeneration. Under normal conditions, IL-1β is present in cells in an inactive form (pro-IL-1β). However, under pathological conditions, pro-IL-1β is turned into its active form (IL-1β) by the inflammasome, a multi-protein complex of the innate immune response that activates ...
Brand, Frank J., Forouzandeh, Mahtab, Kaur, Harmanpreet, Travascio, Francesco, de Rivero Vaccari, Juan Pablo   +4 more
openaire   +2 more sources

Harnessing Metabolic Priming to Engineer Human Nucleus Pulposus Macromass Overcoming Scalability‐Phenotype Tradeoff

Cell Proliferation, EarlyView.
Human platelet lysate acts as a metabolic primer for hNPCs, enhancing fatty acid oxidation to drive proliferation while preserving phenotype. This enables construction of high‐quality, large‐size macromasses without necrotic defects, demonstrating exceptional efficacy in repairing degenerated discs in situ and providing a novel paradigm for ...
Yingbo Wang, Ou Hu, Jian Wu, Sha Huang, Peng Lin, Pulin Yan, Yangyang Li, Huaijian Jin, Yutong Wu, Jun Zhu, Jungang Pu, Bo Hu, Jian He, Yibo Gan, Peng Liu   +14 more
wiley   +1 more source

Serglycin secreted by late-stage nucleus pulposus cells is a biomarker of intervertebral disc degeneration

Nature Communications
Intervertebral disc degeneration is a natural process during aging and a leading cause of lower back pain. Here, we generate a comprehensive atlas of nucleus pulposus cells using single-cell RNA-seq analysis of human nucleus pulposus tissues (three males
Fan Chen, Linchuan Lei, Shunlun Chen, Zhuoyang Zhao, Yuming Huang, Guowei Jiang, Xingyu Guo, Zemin Li, Zhaomin Zheng, Jianru Wang   +9 more
doaj   +1 more source

Newly identified intervertebral fat pad degenerates after intervertebral disc injury in a rat model of degeneration

Journal of Anatomy, EarlyView.
This study characterizes a newly‐described intervertebral fat pad (IVFP) anterior to rat IVDs, with evidence for its existence in mice and human IVDs as well. In rats, the IVFP gradually degenerated following IVD injury with changes in adipocyte size and fibrous tissue infiltration, suggesting it could play a functional role in IVD health and ...
Niklas H. Koehne, Irina Heggli, Agnieszka A. Karol, Alon Lai, Svenja Illien‐Jünger, Andrew C. Hecht, Nilsson Holguin, James C. Iatridis   +7 more
wiley   +1 more source

Utilization of Stem Cells in Alginate for Nucleus Pulposus Tissue Engineering [PDF]

Global Spine Journal, 2014
Introduction In a general view of anatomy, intervertebral disc is composed of three parts: annulus fibrosus, nucleus pulposus (NP), and cartilage endplate. Recently, several types of stem cells were successfully isolated from these corresponding regions, but up to now, no research was performed about which kind ...
Hai, Wang, Yue, Zhou, Bo, Huang, Lan-Tao, Liu, Ming-Han, Liu, Jian, Wang, Chang-Qing, Li, Zhen-Feng, Zhang, Tong-Wei, Chu, Cheng-Jie, Xiong   +9 more
openaire   +2 more sources

Clinical Study of Ultrasound‐Guided Modified Percutaneous Endoscopic Interlaminar Discectomy Combined With Medical Chitosan in Lumbar 4–5 Disc Herniation Treatment

Orthopaedic Surgery, EarlyView.
Ultrasound‐guided PEID plus medical chitosan can effectively reduce postoperative pain and perioperative complications, demonstrating superior clinical efficacy. ABSTRACT Objective Percutaneous endoscopic lumbar discectomy (PELD) is a preferred minimally invasive surgery for lumbar disc herniation (LDH); however, postoperative recurrence, nerve root ...
Liying Cao, Jun Zhang, Mingjing Jiang, Binzhen Lin, Nan Zhong, Xiaofeng Yin, Yiyun Guan, Xiaochun Huang, Kaiming Chen   +8 more
wiley   +1 more source

IL-1β increases asporin expression via the NF-κB p65 pathway in nucleus pulposus cells during intervertebral disc degeneration

Scientific Reports, 2017
Disc degeneration (DD) is a multifaceted chronic process that alters the structure and function of intervertebral discs. The pathophysiology of degeneration is not completely understood, but the consensus is that changes in genes encoding extracellular ...
Shengjie Wang, Chao Liu, Zhongyi Sun, Peng Yan, He Liang, Kai Huang, Changwei Li, Jiwei Tian   +7 more
doaj   +1 more source

Tracing notochord-derived cells using a Noto-cre mouse: implications for intervertebral disc development

Disease Models & Mechanisms, 2012
SUMMARY Back pain related to intervertebral disc degeneration is the most common musculoskeletal problem, with a lifetime prevalence of 82%. The lack of effective treatment for this widespread problem is directly related to our limited understanding of ...
Matthew R. McCann, Owen J. Tamplin, Janet Rossant, Cheryle A. Séguin   +3 more
doaj   +1 more source

From senescence and inflammaging to systemic comorbidities: Drivers of aging‐associated periodontitis

Periodontology 2000, EarlyView.
Abstract Background Aging is accompanied by a chronic low‐grade inflammatory process, known as inflammaging, as well as immunosenescence, an age‐related decline and dysregulation of immune function, and cellular senescence, a process in which cells enter a state of irreversible growth arrest while actively releasing pro‐inflammatory factors.
James Cheng, Chew Tin Zar Aung, Samuel F. Suslavich, Sinem Esra Sahingur, Yvonne L. Hernandez‐Kapila   +4 more
wiley   +1 more source

Effects of zinc finger protein A20 over-expression on inflammatory response and degeneration of human intervertebral disc nucleus pulposus cells stimulated with lipopolysaccharide

Di-san junyi daxue xuebao, 2019
Objective To observe the effects of zinc finger protein A20 over-expression on the expression of inflammatory cytokines and nuclear factor-κB (NF-κB) in human intervertebral disc nucleus pulposus cells and on cell degeneration in response to ...
LAN Haiyang, YANG Zhijie, XIA Huiqiang, CHEN Jie, LIU Bo   +4 more
doaj   +1 more source