Results 81 to 90 of about 4,980,963 (235)

Nucleus pulposus degeneration alters properties of resident progenitor cells [PDF]

The Spine Journal, 2013
The intervertebral disc (IVD) possesses a minimal capability for self-repair and regeneration. Changes in the differentiation of resident progenitor cells can represent diminished tissue regeneration and a loss of homeostasis. We previously showed that progenitor cells reside in the nucleus pulposus (NP). The effect of the degenerative process on these
Olga, Mizrahi, Dmitriy, Sheyn, Wafa, Tawackoli, Shiran, Ben-David, Susan, Su, Ning, Li, Anthony, Oh, Hyun, Bae, Dan, Gazit, Zulma, Gazit   +9 more
openaire   +2 more sources

High BMPR2 expression leads to enhanced SMAD1/5/8 signalling and GDF6 responsiveness in human adipose-derived stem cells: implications for stem cell therapies for intervertebral disc degeneration

Journal of Tissue Engineering, 2020
Stem cell–based regenerative strategies are promising for intervertebral disc degeneration. Stimulation of bone-marrow- and adipose-derived multipotent stem cells with recombinant human growth differentiation factor 6 (rhGDF6) promotes anabolic nucleus ...
Tom Hodgkinson, Francis Wignall, Judith A Hoyland, Stephen M Richardson   +3 more
doaj   +1 more source

Mitochondrial Quality Control in Degenerative Musculoskeletal Diseases: Signaling Networks and Therapeutic Landscapes

Advanced Science, EarlyView.
Mitochondrial quality control (MQC) collapse redefines osteoarthritis, intervertebral disc degeneration, and osteoporosis as disorders of organelle dysfunction. Damaged mitochondria leak mtDNA and metabolites, driving cGAS‐STING inflammation, epigenetic reprogramming, and metabolic memory.
Haiyang Gao, Zhangrong Cheng, Xianglong Chen, Wenbo Wu, Wang Wu, Zimu Yu, Cao Yang, Yukun Zhang   +7 more
wiley   +1 more source

Additional file 2 of Increased hemoglobin and heme in MALDI-TOF MS analysis induce ferroptosis and promote degeneration of herniated human nucleus pulposus

, 2021
Additional file 2: Table S1. Identification results of potential biomarkers in human lumbar discs. Table S2.
Liang Shan (3429260), Ximing Xu (401171), Yingjie Lu (283162), Jiangang Shi (402247), Jing Zhang (23775), Yue Su (11410158), Yinlong Guo (2090758), Han Gao (486886), Peng Cai (1423345)   +8 more
core   +1 more source

The research of transgenic human nucleus pulposus cell transplantation in the treatment of lumbar disc degeneration

Kaohsiung Journal of Medical Sciences, 2019
The present study determines whether the in vivo injection of TGFβ1 and CTGF mediated by AAV2 to transfect nucleus pulposus cells in degenerative lumbar discs can reverse the biological effects of rhesus lumbar disc degeneration.
Hua‐Cong Wang, Cang‐Hai Jin, Jie Kong, Tao Yu, Jian‐Wei Guo, You‐Gu Hu, Yong Liu   +6 more
doaj   +1 more source

Donor‐Cell Senescence Redirects PINK1‐Marked Mitochondrial Cargo From Mitophagy to Microvesicle Transfer Through SUMO3‐Stabilized HSPA9

Advanced Science, EarlyView.
ABSTRACT Extracellular vesicle therapies have been developed for tissue repair, but how donor‐cell senescence reshapes vesicle‐mediated mitochondrial transfer remains unclear. Here, we show that senescent adipose‐derived stem cells (ADSCs) redirect damaged mitochondria into microvesicles (MVs), converting protective vesicles into pro‐degenerative ...
Zixuan Ou, Mingke Zhao, Zhiwei Ling, Lianqi Peng, Bide Tong, Huaizhen Liang, Hongchuan Wang, Di Wu, Yifan Du, Zhi Du, Shihao Zhang, Yuyuan Jia, Yifan Qian, Gan Xu, Liuliang He, Gang Li, Shun Zhang, Lei Tan, Kun Wang, Xiaobo Feng, Cao Yang, Zhiwei Liao   +21 more
wiley   +1 more source

Leptin Activates RhoA/ROCK Pathway to Induce Cytoskeleton Remodeling in Nucleus Pulposus Cells

, 2014
Hyperleptinemia is implicated in obesity-associated lumbar disc degeneration. Nevertheless, the effect of leptin on the intracellular signaling of nucleus pulposus cells is not clear. The current study sought to delineate the possible involvement of the
Jun Yu, Xisheng Weng, Zheng Li, William Wu, Jinqian Liang, Jianxiong Shen, Xin Yu   +6 more
core   +1 more source

Poly-3-hydroxybutyrate-co-3-hydroxyvalerate(PHBV)-Polyethylene glycol 20k(PEG20k) as a promising delivery system for PT2399 in the treatment of disc degeneration

Journal of Biological Engineering
Disc degeneration often leads to a highly prevalent symptom known as low back pain. Healthy nucleus pulposus tissue exhibited a hypoxic environment devoid of blood vessels, while degenerated nucleus pulposus experienced hypoxic deterioration and the ...
Zhencong Li, Weilin Zhang, Shengbang Huang, Zhiwen Dai, Jinguo Liang, Qiulan Qiu, Siyuan Chen, Weixiong Guo, Zhongwei Wang, Jinsong Wei   +9 more
doaj   +1 more source

PHGDH‐Mediated Serine Metabolism in Nucleus Pulposus Cells Is a Potential Therapeutic Target for Intervertebral Disc Degeneration

Advanced Science, EarlyView.
When nucleus pulposus cells senesce, PHGDH decreases, reducing serine synthesis and glutathione, impairing antioxidant capacity. The intermediate α‐KG also drops, lowering JMJD3 demethylase activity, increasing H3K27me3 at the Rap1b promoter, and reducing Rap1b expression, whose down‐regulation in turn activates mTORC1 and suppresses autophagy ...
Hao‐Wei Xu, Sheng‐Jie Chang, Xiao‐Wei Liu, Shu‐Bao Zhang, Ying‐Jie Wang, Shan‐Jin Wang   +5 more
wiley   +1 more source

Difference in Energy Metabolism of Annulus Fibrosus and Nucleus Pulposus Cells of the Intervertebral Disc

, 2011
Low back pain is associated with intervertebral disc degeneration. One of the main signs of degeneration is the inability to maintain extracellular matrix integrity.
Wei Yong Gu, Jessica Czamanski Salvatierra, Fernando, Hanan, Andre Castillo, Herman S. Cheung, Cheung, Herman S, C.-Y. Charles Huang, Yuan, Tai Yi, Castillo, Andre, Tai Yi Yuan, Salvatierra, Jessica Czamanski, Huant, C.-Y. Charles, Gu, Wei Yong, Hanan Fernando   +13 more
core   +1 more source