Results 71 to 80 of about 12,120 (223)

Nucleus pulposus cell network modelling in the intervertebral disc

npj Systems Biology and Applications
Abstract Intervertebral disc degeneration (IDD) results from an imbalance between anabolic and catabolic processes in the extracellular matrix (ECM). Due to complex biochemical interactions, a comprehensive understanding is needed.
Tseranidou, S., Segarra-Queralt, M., Chemorion, F.K., Le Maitre, C.L., Piñero, J., Noailly, J.   +5 more
openaire   +4 more sources

Inhibition of the Notch1 Pathway Promotes the Effects of Nucleus Pulposus Cell-Derived Exosomes on the Differentiation of Mesenchymal Stem Cells into Nucleus Pulposus-Like Cells in Rats [PDF]

Stem Cells International, 2019
Stem cell therapies for intervertebral disc degeneration have been demonstrated as a promising strategy. Previous studies have shown that human nucleus pulposus cell- (NPC-) derived exosomes can induce the differentiation of mesenchymal stem cells (MSCs) into NP-like cells in vitro.
Wei-ren Lan, Sai Pan, Hai-yin Li, Chao Sun, Xian Chang, Kang Lu, Chang-qing Jiang, Rui Zuo, Yue Zhou, Chang-qing Li   +9 more
openaire   +3 more sources

Polymeric hydrogels and decellularized nucleus pulposus extracellular matrix technology for nucleus pulposus repair and regeneration

, 2023
Intervertebral disc degeneration (IVDD) presents in a variety of ways and is first manifested by loss of nucleus pulposus (NP) cells, so replenishing NP cells is the key to IVDD treatment.
Lin Shi, Xiaohui Meng, Lingjia Yu, Bin Zhu, Huajun Dong, Xuan Peng   +5 more
core   +1 more source

Spatiotemporal cellular dynamics of the notochord shape intervertebral disc morphogenesis in the mouse embryo through apoptosis and proliferation

Developmental Dynamics, EarlyView.
Abstract Background The notochord is a midline structure essential for vertebrate embryogenesis, contributing to the development of the nervous system, digestive tract, and vertebral column. In particular, notochord signaling is indispensable for proper patterning and coordinated development of alternating vertebrae and intervertebral discs (IVDs ...
Julie Warin, Estelle Balissat, Pauline Colombier, Lily Paillat, Maeva Dutilleul, Anne Camus   +5 more
wiley   +1 more source

Advanced Molecular Imaging Probes for Skeletal Diseases: Current Progress and Future Perspectives

iRADIOLOGY, EarlyView.
This review summarizes the potential molecular imaging techniques and probes for common orthopedic diseases, such as trauma, infection, metabolism, tumor, joint, spine and other fields, aiming to provide a basis for the development of a new generation of molecular imaging probes.
Shuo Guo, Yuling Cui, Zhiye Fan, Chenxin Jiang, Bowen Fu, Guangbin Cui, Yanli He   +6 more
wiley   +1 more source

The research of transgenic human nucleus pulposus cell transplantation in the treatment of lumbar disc degeneration

Kaohsiung Journal of Medical Sciences, 2019
The present study determines whether the in vivo injection of TGFβ1 and CTGF mediated by AAV2 to transfect nucleus pulposus cells in degenerative lumbar discs can reverse the biological effects of rhesus lumbar disc degeneration.
Hua‐Cong Wang, Cang‐Hai Jin, Jie Kong, Tao Yu, Jian‐Wei Guo, You‐Gu Hu, Yong Liu   +6 more
doaj   +1 more source

Gram positive bacteria within the intervertebral disc and their potential influence on nucleus pulposus cells

, 2023
Introduction Modic changes (MC) that are vertebral bone marrow lesions visualised on magnetic resonance imaging have been associated with disc degeneration. For MC type I one of the identified aetiologies is infection of the intervertebral disc (IVD) [
Lacey, Melissa, Gantenbein, Benjamin, Alexopoulus, Leonidas, Nüesch, Andrea, Kanelis, Exarchos, Breakwell, Lee, Le Maitre, Christine, Williams, Frances   +7 more
core  

Bone morphogenetic proteins for nucleus pulposus regeneration [PDF]

, 2020
Matrix production by nucleus pulposus (NP) cells, the cells residing in the center of the intervertebral disc, can be stimulated by growth factors. Bone morphogenetic proteins (BMPs) hold great promise.
Wouter J. A. Dhert, Kragten, Angela H. M., Dhert, Wouter J. A., Öner, F. Cumhur, Dhert, Wouter J A, Iljas, Juvita D., Tryfonidou, Marianna A., Creemers, Laura B, Kragten, Angela H M, Marianna A. Tryfonidou, Creemers, Laura B; id_orcid, Anita Krouwels, Laura B. Creemers, F. Cumhur Öner, Juvita D. Iljas, Tryfonidou, Marianna A, Iljas, Juvita D, Angela H. M. Kragten, Krouwels, Anita, Öner, F Cumhur, Creemers, Laura B.   +20 more
core   +1 more source

Staging concept for aging management: Definition, mechanism, and coping strategies

VIEW, EarlyView.
We divided the overall aging stage into “pre‐aging”, “aging compensation”, and “aging disability”. For each stage, we delineate the clinical presentations, biological phenomena, theoretical underpinnings, and key management priorities. Abstract Aging, as a gradual and largely irreversible biological process, characterized by declining organismal ...
Zhonghan Wang, Shixian Liu, Shangyu Du, Xiangran Cui, Bo Chao, Minglei Liu, Minfei Wu   +6 more
wiley   +1 more source

Poly-3-hydroxybutyrate-co-3-hydroxyvalerate(PHBV)-Polyethylene glycol 20k(PEG20k) as a promising delivery system for PT2399 in the treatment of disc degeneration

Journal of Biological Engineering
Disc degeneration often leads to a highly prevalent symptom known as low back pain. Healthy nucleus pulposus tissue exhibited a hypoxic environment devoid of blood vessels, while degenerated nucleus pulposus experienced hypoxic deterioration and the ...
Zhencong Li, Weilin Zhang, Shengbang Huang, Zhiwen Dai, Jinguo Liang, Qiulan Qiu, Siyuan Chen, Weixiong Guo, Zhongwei Wang, Jinsong Wei   +9 more
doaj   +1 more source