Results 91 to 100 of about 4,980,963 (235)

Creation of an injectable in situ gelling native extracellular matrix for nucleus pulposus tissue engineering [PDF]

, 2017
Background Context: Disc degeneration is the leading cause of low back pain and is often characterized by a loss of disc height, resulting from cleavage of chondroitin sulfate proteoglycans (CSPGs) present in the nucleus pulposus.
Huda, Hammad I., Rebecca A. Wachs, Christine E. Schmidt, Porvasnik, Stacy L., Wachs, Rebecca A., Hoogenboezem, Ella N., Stacy L. Porvasnik, Hammad I. Huda, Xin, Shangjing, Schmidt, Christine E., Shangjing Xin, Ella N. Hoogenboezem   +11 more
core   +1 more source

Acidification changes affect the inflammasome in human nucleus pulposus cells [PDF]

Journal of Inflammation, 2016
Interleukin (IL)-1β is involved in the pathology of intervertebral disc degeneration. Under normal conditions, IL-1β is present in cells in an inactive form (pro-IL-1β). However, under pathological conditions, pro-IL-1β is turned into its active form (IL-1β) by the inflammasome, a multi-protein complex of the innate immune response that activates ...
Brand, Frank J., Forouzandeh, Mahtab, Kaur, Harmanpreet, Travascio, Francesco, de Rivero Vaccari, Juan Pablo   +4 more
openaire   +2 more sources

Effect of electroacupuncture on expression of autophagy-related proteins in nucleus pulposus of cervical spondylosis rabbits

针刺研究
ObjectiveTo observe the effects of electroacupuncture （EA） on the morphological changes of intervertebral disc tissues， apoptosis of nucleus pulposus cells， and the protein expression of Unc-51 like autophagy-activated kinase 1 （ULK1）， homologous series ...
CHEN Jia-li, ZHAO Zi-ying, GAO Hang, XU Yin-qing, WANG Guang-yi   +4 more
doaj   +2 more sources

Serglycin secreted by late-stage nucleus pulposus cells is a biomarker of intervertebral disc degeneration

Nature Communications
Intervertebral disc degeneration is a natural process during aging and a leading cause of lower back pain. Here, we generate a comprehensive atlas of nucleus pulposus cells using single-cell RNA-seq analysis of human nucleus pulposus tissues (three males
Fan Chen, Linchuan Lei, Shunlun Chen, Zhuoyang Zhao, Yuming Huang, Guowei Jiang, Xingyu Guo, Zemin Li, Zhaomin Zheng, Jianru Wang   +9 more
doaj   +1 more source

Spatiotemporal cellular dynamics of the notochord shape intervertebral disc morphogenesis in the mouse embryo through apoptosis and proliferation

Developmental Dynamics, EarlyView.
Abstract Background The notochord is a midline structure essential for vertebrate embryogenesis, contributing to the development of the nervous system, digestive tract, and vertebral column. In particular, notochord signaling is indispensable for proper patterning and coordinated development of alternating vertebrae and intervertebral discs (IVDs ...
Julie Warin, Estelle Balissat, Pauline Colombier, Lily Paillat, Maeva Dutilleul, Anne Camus   +5 more
wiley   +1 more source

Untethered Electrical Stimulation Using Optoelectricity and Piezoelectricity for Tissue Regeneration

FlexTech, EarlyView.
Untethered electrical stimulation from optoelectronic and piezoelectric materials can aid regeneration of damaged tissue. ABSTRACT Electrical signals are increasingly recognized as important regulators of tissue development and regeneration, with outcomes linked to behaviors including proliferation, differentiation, cell migration, and more.
Ryan Yao, Baochun Xu, Cunjiang Yu
wiley   +1 more source

Different isolation methods for nucleus pulposus progenitor cells [PDF]

, 2019
Introduction: Nucleus Pulposus Progenitor Cells (NPPCs), positive for the angiopoietin-1 receptor (Tie2), were demonstrated in human, mouse, canine and bovine NP tissue.
Stoyanov, Jivko, Gantenbein, Benjamin, Sakai, Daisuke, Schol, Jordy, Frauchiger, Daniela A, Tekari, Adel, Zhang, Xingshuo, Chan, Samantha C.W., Bertolo, Alessandro, Benneker, Lorin M., Grad, Sibylle, May, Rahel, Dzafo, Emina, Tryfonidou, Marianna   +13 more
core  

Role of hypoxia and growth and differentiation factor-5 on differentiation of human mesenchymal stem cells towards intervertebral nucleus pulposus-like cells [PDF]

, 2011
There is evidence that mesenchymal stem cells (MSCs) can differentiate towards an intervertebral disc (IVD)-like phenotype. We compared the standard chondrogenic protocol using transforming growth factor beta-1 (TGFß) to the effects of hypoxia, growth ...
Aebli, N, M Alini, M Baur, N Aebli, Bertolo, A, Grad, S, B Gantenbein-Ritter, Gantenbein-Ritter, Benjamin, Alini, M, JV Stoyanov, A Bertolo, Stoyanov, JV, Baur, M, S Grad, Baur M, Stoyanov JV, Bertolo A, Aebli N, Gantenbein-Ritter B, Alini M, Grad S   +20 more
core   +1 more source

Itgb1‐Mediated Stabilization of Vimentin Alleviates Excessive Mechanical Stress‐Induced Nucleus Pulposus Cell Pyroptosis and Intervertebral Disc Degeneration via PINK1‐Parkin‐Dependent Mitophagy

Cell Proliferation, EarlyView.
Excessive mechanical stress induces nucleus pulposus cell pyroptosis and intervertebral disc degeneration. Itgb1 inhibits MNAT1‐mediated ubiquitination and degradation of Vimentin. Vimentin alleviates excessive mechanical stress‐induced nucleus pulposus cell pyroptosis and intervertebral disc degeneration through PINK1‐Parkin‐dependent mitophagy ...
Xuening Liu, Fengguang Yang, Yanni Duan, Hefang Xiao, Zhenyu Cao, Zhaoheng Wang, Haijun Zhang, Xuewen Kang   +7 more
wiley   +1 more source

Can PPARδ agonist increase cell yield of nucleus pulposus progenitor cells positive for angiopoietin-1 receptor (= TIE2) after cell isolation? [PDF]

, 2019
Introduction: Nucleus pulposus progenitor cells (NPPC), Tie2+ cells (positive for angiopoietin receptor), which possess multi-lineage differential potential is a potential cell population for cell therapy.
Benneker, Lorin M., Gantenbein, Benjamin, Sakai, Daisuke, May, Rahel D., Frauchiger, Daniela A., Dzafo, Emina, Zhang, Xingshuo, Tekari, Adel, Tryfonidou, Marianna   +8 more
core