Results 91 to 100 of about 12,120 (223)

Overexpression of microRNA-185 alleviates intervertebral disc degeneration through inactivation of the Wnt/-catenin signaling pathway and downregulation of Galectin-3

Molecular Pain, 2020
Background Recent studies have found that microRNAs (miRNAs) play a critical role in development and progression of intervertebral disc degeneration. In the present study, we examined the role of miR-185 in nucleus pulposus cell behavior in vitro and the
Zhennan Yun, Yuhang Wang, Wei Feng, Junting Zang, Daguang Zhang, Yuhang Gao   +5 more
doaj   +1 more source

The enigma that is the nucleus pulposus cell: the search goes on [PDF]

Arthritis Research & Therapy, 2010
The development of an effective treatment for degenerative disc disease has been hampered for many years by what seems a fundamental problem; what exactly defines a nucleus pulposus (NP) cell? The paper by Gilson and colleagues elegantly re-opens the debate concerning the lineage and identity of NP cells that are alike yet different from chondrocytes ...
openaire   +1 more source

Canonical and non‐canonical functions of proteins regulating mitochondrial dynamics in mammalian physiology

The Journal of Physiology, EarlyView.
Abstract figure legend Mitochondria are highly dynamic organelles that continuously remodel their architecture through coordinated cycles of fusion and fission. This review examines the four key GTPases that orchestrate mitochondrial dynamics in mammals: MFN1, MFN2, OPA1, and DRP1.
Rémi Chaney, Vincent Marcangeli, Krystel Desjardins, Shima Taherkhani, Gilles Gouspillou   +4 more
wiley   +1 more source

Different isolation methods for nucleus pulposus progenitor cells

, 2019
Introduction: Nucleus Pulposus Progenitor Cells (NPPCs), positive for the angiopoietin-1 receptor (Tie2), were demonstrated in human, mouse, canine and bovine NP tissue.
Stoyanov, Jivko, Gantenbein, Benjamin, Sakai, Daisuke, Schol, Jordy, Frauchiger, Daniela A, Tekari, Adel, Zhang, Xingshuo, Chan, Samantha C.W., Bertolo, Alessandro, Benneker, Lorin M., Grad, Sibylle, May, Rahel, Dzafo, Emina, Tryfonidou, Marianna   +13 more
core  

Characterization of the age-dependent intervertebral disc changes in rabbit by correlation between MRI, histology and gene expression

BMC Musculoskeletal Disorders, 2011
Background The present study was conducted to address whether the intervertebral disc of rabbit could be considered (i) as a valuable model to provide new insights into the tissue and cellular changes of Nucleus pulposus aging and (ii) as an appropriate ...
Gauthier Olivier, Fellah Borhane H, Lesoeur Julie, Masson Martial, Grimandi Gaël, Pot-Vaucel Marianne, Clouet Johann, Fusellier Marion, Cherel Yan, Maugars Yves, Guicheux Jérôme, Vinatier Claire   +11 more
doaj   +1 more source

Can PPARδ agonist increase cell yield of nucleus pulposus progenitor cells positive for angiopoietin-1 receptor (= TIE2) after cell isolation?

, 2019
Introduction: Nucleus pulposus progenitor cells (NPPC), Tie2+ cells (positive for angiopoietin receptor), which possess multi-lineage differential potential is a potential cell population for cell therapy.
Benneker, Lorin M., Gantenbein, Benjamin, Sakai, Daisuke, May, Rahel D., Frauchiger, Daniela A., Dzafo, Emina, Zhang, Xingshuo, Tekari, Adel, Tryfonidou, Marianna   +8 more
core  

Biomaterial Physical Cues as Gene Regulators for Cellular Agriculture

Advanced Genetics, Volume 7, Issue 2, June 2026.
This review elucidates how biomaterial physical cues—ranging from matrix stiffness to remote electromagnetic fields—serve as extrinsic regulators of gene expression in cellular agriculture. By identifying central mechanotransduction pathways that bridge physical inputs to genetic remodeling, the authors propose the “Material Genome” concept: a ...
Jianuo Liu, Ye Liu
wiley   +1 more source

In vitro analysis of osteogenic inhibition in non-union spinal fusion caused by nucleus pulposus cells.

, 2015
Discectomy and spinal fusion is the gold standard for spinal surgery to relieve pain. However, fusion can be hindered for yet unknown reasons that lead to non-fusions with pseudo-arthrosis.
Gantenbein, Benjamin, Chan, Samantha, Frauchiger, Daniela Angelika, Heini, Paul Ferdinand, Tekari, Adel, Benneker, Lorin Michael   +5 more
core  

Genes with significant expression levels in serum-starved nucleus pulposus cells transfected with caspase 3 siRNA.

, 2013
Genes with significant expression levels in serum-starved nucleus pulposus cells transfected with caspase 3 siRNA.
Koji Iwasaki (387364), Hideaki Higashi (387365), Norimasa Iwasaki (317545), Akio Minami (317559), Katsuhisa Yamada (387363), Manabu Ito (387366), Hideki Sudo (387362)   +6 more
core   +1 more source

Secretome and Pathway Analysis of Stress Induced Disc Degeneration In Vitro

JOR SPINE, Volume 9, Issue 2, June 2026.
Integrated secretome and phosphoprotein profiling of human nucleus pulposus cells revealed that IL‐1β and TLR2/6 activation induce a shared degenerative program, defined by consistent upregulation of IL‐6, IL‐8, GRO‐α, ICAM‐1, and MMP‐7 and convergence on NF‐κB/AP‐1 signaling.
Exarchos Kanelis, Andrea Nüesch, Joseph Snuggs, Christine Lyn Le Maitre, Leonidas G. Alexopoulos   +4 more
wiley   +1 more source