Results 61 to 70 of about 4,980,963 (235)

ACSL4‐Dependent Lysosomal Lipid Peroxidation Links WTAP‐Mediated m6A Modification to Intervertebral Disc Degeneration

Advanced Science, EarlyView.
IL‐1β upregulates the protein level of WTAP, which promotes the m6A modification of ACSL4 mRNA in an IGF2BP2‐dependent manner, thereby enhancing its stability. The increased ACSL4 drives lipid peroxidation, leading to lysosomal membrane permeabilization (LMP) and impaired mitophagy, which collectively accelerate intervertebral disc degeneration (IVDD).
Shu Jia, Xu Gao, Laimin Zhu, Haixia Song, Jing Wu, Shang Chen, Sheng Gao, Lu Zhang, Chunyang Meng   +8 more
wiley   +1 more source

Influence of Age-Related Degeneration on Regenerative Potential of Human Nucleus Pulposus Cells

, 2011
Nucleus pulposus (NP) cells, sourced from herniation surgeries, may be used as a cell-based therapy for intervertebral disc (IVD) degeneration. But, both the regenerative potential of these degenerative adult NP cells and how to stimulate optimum matrix ...
楊曙華;林鎮江;胡名孝;施庭芳;孫元蕙;林峰輝, YANG, SHU-HUA;LIN, CHEN-CHIANG;HU, MING-HSIAO;SHIH, TIFFANY TING-FANG;SUN, YUAN-HUI;LIN, FENG- HUEI;LIN, FENG-HUEI   +1 more
core   +1 more source

Exhaustion of nucleus pulposus progenitor cells with ageing and degeneration of the intervertebral disc. [PDF]

, 2012
Despite the high prevalence of intervertebral disc disease, little is known about changes in intervertebral disc cells and their regenerative potential with ageing and intervertebral disc degeneration.
Mishima, Taishi, Alini, Mauro, Nakamura, Yoshihiko, Mochida, Joji, Sakai, Daisuke, Risbud, Makarand V, Kato, Shunichi, Nakai, Tomoko, Chan, Danny, Grad, Sibylle, Masuda, Koichi, Cheah, Kathryn S E, Yamamura, Ken-ichi, Ando, Kiyoshi, Okano, Hideyuki   +14 more
core   +2 more sources

Hyperosmolar expansion medium improves nucleus pulposus cell phenotype

JOR SPINE, 2022
AbstractBackgroundRepopulating the degenerated intervertebral disc (IVD) with tissue‐specific nucleus pulposus cells (NPCs) has already been shown to promote regeneration in various species. Yet the applicability of NPCs as cell‐based therapy has been hampered by the low cell numbers that can be extracted from donor IVDs and their potentially limited ...
Laagland, Lisanne T., Bach, Frances C., Creemers, Laura B., Le Maitre, Christine L., Poramba‐Liyanage, Deepani W., Tryfonidou, Marianna A.   +5 more
openaire   +6 more sources

Restoration of m6A‐Modified circPSMB1 Suppresses Chordoma Progression and Enables Local Nanotherapeutic Intervention

Advanced Science, EarlyView.
An m6A‐modified circRNA, circPSMB1, is identified as a tumor suppressor in chordoma. METTL3‐dependent m6A promotes circPSMB1 interaction with HNRNPA2B1, limiting c‐MYC expression and malignant progression. An injectable HMnO2‐based nanohydrogel enables local circPSMB1 delivery and tumor microenvironment‐responsive therapy, offering a promising strategy
Yingchuang Tang, Liang Qiu, Xingbang Ruan, Yihan Shi, Ye Wang, Hanwen Li, Kai Zhang, Kangwu Chen   +7 more
wiley   +1 more source

Genes with significant expression levels in serum-starved nucleus pulposus cells transfected with caspase 3 siRNA.

, 2013
Genes with significant expression levels in serum-starved nucleus pulposus cells transfected with caspase 3 siRNA.
Koji Iwasaki (387364), Hideaki Higashi (387365), Norimasa Iwasaki (317545), Akio Minami (317559), Katsuhisa Yamada (387363), Manabu Ito (387366), Hideki Sudo (387362)   +6 more
core   +1 more source

VnP-16 reduces inflammatory cytokine expression in the nucleus pulposus of mice with SpA.

, 2022
IL-1β, IL-6, TNF-α, IL-17A expressing cells were enumerated in the nucleus pulposus by immunohistochemical staining (n = 6 per group). ns, non-significant, *P P P < 0.001.
Seon-Yeong Lee (403007), JeongWon Choi (4900684), Sung-Hwan Park (26633), A. Ram Lee (11785412), Mi-La Cho (46882), Hong Ki Min (9417766), Byung-Moo Min (11909720)   +6 more
core   +1 more source

Systematic analysis of lysine lactylation in nucleus pulposus cells

iScience
Nucleus pulposus (NP) resides in hypoxic microenvironment and NP cells (NPCs), primarily reply on glycolysis and producing high levels of lactate. Intracellular lactate drives lysine lactylation (Kla) as a newly epigenetic modification. However, the impact of Kla on NPCs remains unknown.
Lei Sheng, Haoran Xu, Yuexing Wang, Jinhao Ni, Taiyang Xiang, Huanhuan Xu, Xiaozhong Zhou, Kang Wei, Jun Dai   +8 more
openaire   +3 more sources

Impaired Chaperone‐Mediated Autophagy Accelerates Intervertebral Disc Degeneration by Inducing MIDN Accumulation to Target TSC2 for Proteasomal Degradation

Advanced Science, EarlyView.
This graphical abstract illustrates how chaperone‐mediated autophagy (CMA) regulates intervertebral disc degeneration (IDD). Under normal homeostasis (B), CMA degrades cytoplasmic Midnolin (MIDN) to maintain proteostasis. Under inflammatory stress (A), impaired CMA leads to cytoplasmic MIDN accumulation.
Xianglong Chen, Haiyang Gao, Wang Wu, Pengzhi Shi, Yuhang Chen, Anran Zhang, Zhangrong Cheng, Wenbo Wu, Zimu Yu, Yukun Zhang   +9 more
wiley   +1 more source

An Injectable ROS‐Responsive Nanozyme Hydrogel Regulates the Uterine Microenvironment to Prevent Intrauterine Adhesions

Advanced Science, EarlyView.
The injectable CeTA@GPP hydrogel is administered via intrauterine injection, forming a protective barrier. In the high ROS inflammatory microenvironment of injured endometrium, boronate ester cleavage triggers responsive CeTA release and local enrichment.
Peixian Cheng, Jian Song, Yuxin Li, Ming Chen, Zeshen Liang, Binyao Qiu, Xuemin Liu, Xuetao Shi, Yong Fan   +8 more
wiley   +1 more source